日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Angiopoietin-2 aggravates Alzheimer's disease by promoting blood-brain barrier dysfunction and neuroinflammation.

血管生成素-2通过促进血脑屏障功能障碍和神经炎症加剧阿尔茨海默病。

Lee Eunhyeong, Kim Seoyeon, Zhu Claire L, Acquarone Erica, Kim Sungsoo, Lo An, Omar Omar M F, Taddese Maraake, Gradinaru Viviana, Murphy Patrick A, Agalliu Dritan, Arancio Ottavio, An Joon-Yong, Kim Minah

The Highly Selective 5-HT(2B) Receptor Antagonist MW073 Mitigates Aggressive Behavior in an Alzheimer's Disease Mouse Model

高选择性5-HT(2B)受体拮抗剂MW073可减轻阿尔茨海默病小鼠模型中的攻击性行为

Acquarone, Erica; Roy, Saktimayee M; Staniszewski, Agnieszka; Watterson, Daniel Martin; Arancio, Ottavio

Synaptic mitochondria glycation contributes to mitochondrial stress and cognitive dysfunction.

突触线粒体糖化会导致线粒体应激和认知功能障碍

Samanta Sourav, Akhter Firoz, Xue Renhao, Sosunov Alexandre A, Wu Long, Chen Doris, Arancio Ottavio, Yan Shi Fang, Yan Shirley ShiDu

Synaptic and cognitive impairment associated with L444P heterozygous glucocerebrosidase mutation.

与 L444P 杂合葡糖脑苷脂酶突变相关的突触和认知障碍

Lado Wudu, Ham Ahrom, Li Hongyu, Zhang Hong, Chang Audrey Yuen, Sardi Sergio Pablo, Alcalay Roy N, Arancio Ottavio, Przedborski Serge, Tang Guomei

PP2A methylesterase, PME-1, and PP2A methyltransferase, LCMT-1, control sensitivity to impairments caused by injury-related oligomeric tau.

PP2A 甲基酯酶 PME-1 和 PP2A 甲基转移酶 LCMT-1 控制着对损伤相关寡聚 tau 引起的损伤的敏感性。

Sundaresh Sowmya N, Vogel Edward W 3rd, Hue Christopher D, Zhang Hong, Staniszewski Anna, Berman Hanna L, Gill Zafar, Asam Kesava, Liang Siqi, Shen Liwei, Gnanaprakash Madhumathi, Acquarone Erica, Masone Antonio, Fà Mauro, Kanaan Nicholas M, Morrison Barclay 3rd, Arancio Ottavio, Nicholls Russell E

Optimized 5-HT(2b) inhibitors for neuropsychiatric syndromes with cognitive dysfunction

针对伴有认知功能障碍的神经精神综合征的优化型 5-HT(2b) 抑制剂

Roy, Saktimayee M; Acquarone, Erica; Argyrousi, Elentina K; Zhang, Hong; Staniszewski, Agnieszka; Inoue, Asuka; Ziarek, Joshua J; Arancio, Ottavio; Watterson, D Martin

Discovery of Indole-Based PDE5 Inhibitors: Synthesis and Pharmacological Evaluation

吲哚类PDE5抑制剂的发现:合成与药理学评价

Park, Shin-Young; Pham, Dang; Shukla, Param; Edward, Justin; John, Reshmi; Li, Addison; Hadjiargyrou, Michael; Mori, Mattia; Zuccarello, Elisa; Arancio, Ottavio; Fiorito, Jole

Discovery of small molecule candidate therapeutics against neuroimmune targets in Alzheimer’s disease

发现针对阿尔茨海默病神经免疫靶点的小分子候选疗法

Islam, Rezwanul; Vrionis, Frank; Hanafy, Khalid A; Eldik, Linda Jo Van; Roy, Saktimayee M; Arancio, Ottavio; Watterson, D Martin

Endogenously generated Dutch-type Aβ nonfibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation

内源性生成的荷兰型Aβ非纤维聚集体在没有可检测到的炎症的情况下会扰乱突触前神经传递。

Castranio, Emilie L; Varghese, Merina; Argyrousi, Elentina K; Tripathi, Kuldeep; Söderberg, Linda; Bresnahan, Erin; Lerner, David; Garretti, Francesca; Zhang, Hong; van de Loo, Jonathan; Stimpson, Cheryl D; Talty, Ronan; Glabe, Charles; Levy, Efrat; Wang, Minghui; Ilkov, Marjan; Zhang, Bin; Lannfelt, Lars; Guérin, Brigitte; Lubell, William D; Rahimipour, Shai; Dickstein, Dara L; Gandy, Sam; Arancio, Ottavio; Ehrlich, Michelle E

The interaction between neurotransmitter receptor activity and amyloid-β pathology in Alzheimer's disease

阿尔茨海默病中神经递质受体活性与β-淀粉样蛋白病理的相互作用

Nong, Yuhan; Kim, Jung Soo; Jia, Litian; Arancio, Ottavio; Wang, Qi