Discovery of MDI-114215: A Potent and Selective LIMK Inhibitor To Treat Fragile X Syndrome.
MDI-114215 的发现:一种强效且选择性的 LIMK 抑制剂,可用于治疗脆性 X 综合征
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.4c02694
Baldwin Alex G, Foley David W, Collins Ross, Lee Hyunah, Jones D Heulyn, Wahab Ben, Waters Loren, Pedder Josephine, Paine Marie, Feng Gui Jie, Privitera Lucia, Ashall-Kelly Alexander, Thomas Carys, Gillespie Jason A, Schino Lauramariú, Belelli Delia, Rocha Cecilia, Maussion Gilles, Krahn Andrea I, Durcan Thomas M, Elkins Jonathan M, Lambert Jeremy J, Atack John R, Ward Simon E