日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Characterization of a conserved outer-membrane protein in non-typeable Haemophilus influenzae with an unidentified impact on phenotype

对非典型流感嗜血杆菌中一种保守的外膜蛋白进行表征,该蛋白对表型的影响尚不明确

Fraser, Ashley J; Cooper, Oren; Forde, Brian M; Murphy, Timothy F; Jennings, Michael P; Atack, John M

Negative allosteric modulation of α5-GABA(A) receptors engages dynamic cortical glutamatergic and GABAergic mechanisms underlying adaptive behavior in mice.

α5-GABA(A)受体的负变构调节激活了小鼠适应性行为背后的动态皮质谷氨酸能和GABA能机制。

Daher Fernanda, Fukushima Caio T, Ingebretsen Erik A, Bidlack Jean M, Atack John R, Popa Mariana O, Fogaça Manoela V

Tetrahydropyrazolopyridinones as a Novel Class of Potent and Highly Selective LIMK Inhibitors

四氢吡唑并吡啶酮类化合物作为一类新型高效高选择性LIMK抑制剂

Baldwin, Alex G; Foley, David W; Jones, D Heulyn; Lee, Hyunah; Collins, Ross; Wahab, Ben; Pedder, Josephine H; Waters, Loren; Paine, Marie; Schino, Lauramariú; Feng, Gui Jie; Kariuki, Benson M; Elkins, Jonathan M; Atack, John R; Ward, Simon E

Discovery of MDI-114215: A Potent and Selective LIMK Inhibitor To Treat Fragile X Syndrome.

MDI-114215 的发现:一种强效且选择性的 LIMK 抑制剂,可用于治疗脆性 X 综合征

Baldwin Alex G, Foley David W, Collins Ross, Lee Hyunah, Jones D Heulyn, Wahab Ben, Waters Loren, Pedder Josephine, Paine Marie, Feng Gui Jie, Privitera Lucia, Ashall-Kelly Alexander, Thomas Carys, Gillespie Jason A, Schino Lauramariú, Belelli Delia, Rocha Cecilia, Maussion Gilles, Krahn Andrea I, Durcan Thomas M, Elkins Jonathan M, Lambert Jeremy J, Atack John R, Ward Simon E

Neurosteroid Modulation of Synaptic and Extrasynaptic GABAA Receptors of the Mouse Nucleus Accumbens

神经类固醇对小鼠伏隔核突触和突触外 GABAA 受体的调节

Scott J Mitchell, Grant D Phillips, Becks Tench, Yunkai Li, Delia Belelli, Stephen J Martin, Jerome D Swinny, Louise Kelly, John R Atack, Michael Paradowski, Jeremy J Lambert

Phasevarions in Haemophilus influenzae biogroup aegyptius control expression of multiple proteins

流感嗜血杆菌埃及生物群的阶段变异控制多种蛋白质的表达

Greg Tram, Freda E-C Jen, Zachary N Phillips, John F Lancashire, Jamie Timms, Jessica Poole, Michael P Jennings, John M Atack

Microbial Primer: Phase variation - survival and adaptability by generation of a diverse population

微生物入门:相变——通过产生多样化的种群来实现生存和适应

Fraser, Ashley J; McMahon, Finn E; Atack, John M

Quantitative measurement of changes in amyloid-beta(40) in the rat brain and cerebrospinal fluid following treatment with the gamma-secretase inhibitor LY-411575 [N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide]

使用 γ-分泌酶抑制剂 LY-411575 [N2-[(2S)-2-(3,5-二氟苯基)-2-羟基乙酰基]-N1-[(7S)-5-甲基-6-氧代-6,7-二氢-5H-二苯并[b,d]氮杂卓-7-基]-L-丙氨酰胺] 治疗后,定量测量大鼠脑和脑脊液中淀粉样蛋白-β(40) 的变化

Jonathan D Best, Mark T Jay, Franklin Otu, Jerome Ma, Alan Nadin, Semantha Ellis, Huw D Lewis, Christine Pattison, Michael Reilly, Timothy Harrison, Mark S Shearman, Toni L Williamson, John R Atack

A comparative assessment of gamma-secretase activity in transgenic and non-transgenic rodent brain

转基因和非转基因啮齿动物脑中γ-分泌酶活性的比较评估

Julian L Goggi, Huw D Lewis, Joanie Mok, Tim Harrison, Mark S Shearman, John R Atack, Jonathan D Best

Basmisanil, an α5-GABA(A)R negative allosteric modulator, produces rapid and sustained antidepressant-like responses in male mice

Basmisanil 是一种 α5-GABA(A)R 负变构调节剂,可在雄性小鼠中产生快速且持续的抗抑郁样反应。

Daher, Fernanda; Villalobos, Narcy A; Hanley, Marcus; Atack, John R; Popa, Mariana O; Fogaça, Manoela V