Badr Christian E相关文献与解析，生知库 | 链接生命科学的每一步

Kshirsagar Anannya, Mnatsakanyan Hayk, Kulkarni Sai, Guo John, Cheng Kai, Ofria Luke Daniel, Bohra Oce, Sagar Ram, Mahairaki Vasiliki, Badr Christian E, Kathuria Annie

神经科学

3D/类器官

发表日期：2025

文献求助收藏

Targeting SCD triggers lipotoxicity of cancer cells and enhances anti-tumor immunity in breast cancer brain metastasis mouse models.

靶向 SCD 可引发癌细胞的脂毒性，并增强乳腺癌脑转移小鼠模型的抗肿瘤免疫力

期刊:Communications Biology

影响因子:5.1

doi:10.1038/s42003-025-07977-1

Sammarco Alessandro, Guerra Giorgia, Eyme Katharina M, Kennewick Kelly, Qiao Yu, El Hokayem Joelle, Williams Kevin J, Su Baolong, Cakici Cagri, Mnatsakanyan Hayk, Zappulli Valentina, Bensinger Steven J, Badr Christian E

Dual-action nanotherapy: Temozolomide-loaded, anti-PD-L1 scFv-functionalized lipid nanocarriers for targeted glioblastoma therapy

双效纳米疗法：载有替莫唑胺、抗PD-L1 scFv功能化的脂质纳米载体用于靶向胶质母细胞瘤治疗

期刊:European Journal of Pharmaceutical Sciences

影响因子:4.7

doi:10.1016/j.ejps.2025.107255

Aytekin, Eren; Maksoud, Semer; Tannous, Bakhos A; Pehlivan, Sibel Bozdağ; Badr, Christian E

Current and Emerging Fluorescence-Guided Techniques in Glioma to Enhance Resection

目前及新兴的荧光引导技术在胶质瘤切除术中的应用

期刊:Cancers

影响因子:4.4

doi:10.3390/cancers17162702

Nguyen, Trang T T; Mnatsakanyan, Hayk; Yi, Eunhee; Badr, Christian E

胶质瘤

发表日期：2025

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Exploiting Synthetic Lethality of PRMT5 for Precision Treatment of MTAP-Deficient Glioblastoma

利用PRMT5的合成致死性精准治疗MTAP缺陷型胶质母细胞瘤

期刊:

影响因子:

doi:10.3390/ijtm5030027

Nguyen, Trang T T; Yi, Eunhee; Badr, Christian E

SCD1 and SCD5 Modulate PARP-Dependent DNA Repair via Fatty Acid Desaturation in Glioblastoma.

SCD1 和 SCD5 通过脂肪酸去饱和作用调节胶质母细胞瘤中 PARP 依赖性 DNA 修复

期刊:

影响因子:

doi:10.1101/2025.07.23.666454

Mnatsakanyan Hayk, Sammarco Alessandro, Awwad Rami, Hewett Abigail, Roumieh Elie, Pechdimaljian Caline, Azar Yana, Pradhan Richa, Su Baolong, Williams Kevin J, Bensinger Steven J, Badr Christian E

细胞生物学

发表日期：2025

文献求助收藏

Revolutionizing Brain Tumor Care: Emerging Technologies and Strategies

革新脑肿瘤治疗：新兴技术与策略

期刊:Biomedicines

影响因子:3.9

doi:10.3390/biomedicines12061376

Nguyen, Trang T T; Greene, Lloyd A; Mnatsakanyan, Hayk; Badr, Christian E

Diastereomers of Coibamide A Show Altered Sec61 Client Selectivity and Ligand-Dependent Activity against Patient-Derived Glioma Stem-like Cells.

Coibamide A 的非对映异构体对 Sec61 底物选择性和配体依赖性活性有改变，可对抗患者来源的胶质瘤干细胞样细胞

期刊:ACS Pharmacology and Translational Science

影响因子:3.7

doi:10.1021/acsptsci.4c00049

Mattos Daphne R, Neves Willian das, Kitamura Takashi, Pradhan Richa, Wan Xuemei, da Hora Cintia Carla, Tranter Dale, Kazemi Soheila, Yu Xinhui, Tripathy Nirmalya, Paavilainen Ville O, McPhail Kerry L, Oishi Shinya, Badr Christian E, Ishmael Jane E

Expression-based selection identifies a microglia-tropic AAV capsid for direct and CSF routes of administration in mice

基于表达的筛选鉴定出一种嗜小胶质细胞的AAV衣壳，可用于小鼠的直接给药和脑脊液给药。

期刊:

影响因子:

doi:10.1101/2024.09.25.614546

Santoscoy, Miguel C; Espinoza, Paula; Hanlon, Killian S; Yang, Luna; Nieland, Lisa; Ng, Carrie; Badr, Christian E; Hickman, Suzanne; de la Cruz, Demitri; Griciuc, Ana; Elkhoury, Joseph; Bennett, Rachel E; Shen, Shiqian; Maguire, Casey A

Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblastoma mouse models

靶向从头脂质合成会诱导胶质母细胞瘤小鼠模型出现脂毒性并损害DNA损伤修复。

期刊:Science Translational Medicine

影响因子:14.6

doi:10.1126/scitranslmed.abq6288

Eyme, Katharina M; Sammarco, Alessandro; Jha, Roshani; Mnatsakanyan, Hayk; Pechdimaljian, Caline; Carvalho, Litia; Neustadt, Rudolph; Moses, Charlotte; Alnasser, Ahmad; Tardiff, Daniel F; Su, Baolong; Williams, Kevin J; Bensinger, Steven J; Chung, Chee Yeun; Badr, Christian E

Multi-Region Brain Organoids Integrating Cerebral, Mid-Hindbrain, and Endothelial Systems.

整合大脑、中脑-后脑和内皮系统的多区域脑类器官

Targeting SCD triggers lipotoxicity of cancer cells and enhances anti-tumor immunity in breast cancer brain metastasis mouse models.

靶向 SCD 可引发癌细胞的脂毒性，并增强乳腺癌脑转移小鼠模型的抗肿瘤免疫力

Dual-action nanotherapy: Temozolomide-loaded, anti-PD-L1 scFv-functionalized lipid nanocarriers for targeted glioblastoma therapy

双效纳米疗法：载有替莫唑胺、抗PD-L1 scFv功能化的脂质纳米载体用于靶向胶质母细胞瘤治疗

Current and Emerging Fluorescence-Guided Techniques in Glioma to Enhance Resection

目前及新兴的荧光引导技术在胶质瘤切除术中的应用

Exploiting Synthetic Lethality of PRMT5 for Precision Treatment of MTAP-Deficient Glioblastoma

利用PRMT5的合成致死性精准治疗MTAP缺陷型胶质母细胞瘤

SCD1 and SCD5 Modulate PARP-Dependent DNA Repair via Fatty Acid Desaturation in Glioblastoma.

SCD1 和 SCD5 通过脂肪酸去饱和作用调节胶质母细胞瘤中 PARP 依赖性 DNA 修复

Revolutionizing Brain Tumor Care: Emerging Technologies and Strategies

革新脑肿瘤治疗：新兴技术与策略

Diastereomers of Coibamide A Show Altered Sec61 Client Selectivity and Ligand-Dependent Activity against Patient-Derived Glioma Stem-like Cells.

Coibamide A 的非对映异构体对 Sec61 底物选择性和配体依赖性活性有改变，可对抗患者来源的胶质瘤干细胞样细胞

Expression-based selection identifies a microglia-tropic AAV capsid for direct and CSF routes of administration in mice

基于表达的筛选鉴定出一种嗜小胶质细胞的AAV衣壳，可用于小鼠的直接给药和脑脊液给药。

Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblastoma mouse models

靶向从头脂质合成会诱导胶质母细胞瘤小鼠模型出现脂毒性并损害DNA损伤修复。