Bae Sangsu相关文献与解析，生知库 | 链接生命科学的每一步

Nam, Bae-Geun; Seo, Jung Hwa; Hong, Sung-Ah; Kim, Ju-Hee; Kang, Minju; Notario, Geneva Rose; Hong, Yoontaik; Cho, Seunghee; Bae, Sangsu; Cho, Sung-Rae

碱基编辑

发表日期：2026

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Large DNA deletions occur during DNA repair at 20-fold lower frequency for base editors and prime editors than for Cas9 nucleases.

DNA修复过程中，碱基编辑器和启动子编辑器导致大片段DNA缺失的频率比Cas9核酸酶低20倍

期刊:Nature Biomedical Engineering

影响因子:26.6

doi:10.1038/s41551-024-01277-5

Hwang Gue-Ho, Lee Seok-Hoon, Oh Minsik, Kim Segi, Habib Omer, Jang Hyeon-Ki, Kim Heon Seok, Kim Youngkuk, Kim Chan Hyuk, Kim Sun, Bae Sangsu

其它

发表日期：2025

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A rational engineering strategy for structural dynamics modulation enables target specificity enhancement of the Cas9 nuclease

通过合理的结构动力学调控工程策略，可以提高Cas9核酸酶的靶向特异性。

期刊:Nucleic Acids Research

影响因子:13.1

doi:10.1093/nar/gkaf535

Sung, Keewon; Jung, Youngri; Kim, Nahye; Kim, Yong-Woo; Kim, Hyongbum Henry; Kim, Seong Keun; Bae, Sangsu

信号转导

发表日期：2025

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Autophagy induction enhances homologous recombination-associated CRISPR-Cas9 gene editing.

自噬诱导增强同源重组相关的 CRISPR-Cas9 基因编辑

期刊:Nucleic Acids Research

影响因子:13.1

doi:10.1093/nar/gkaf258

Nam Hye Jin, Han Jun Hee, Yu Jihyeon, Cho Chang Sik, Kim Dongha, Kim Young Eun, Kim Min Ji, Kim Jeong Hun, Jo Dong Hyun, Bae Sangsu

Bystander editing by adenine base editors impairs vision restoration in a mouse model of Leber congenital amaurosis.

旁观者通过腺嘌呤碱基编辑器进行的编辑会损害 Leber 先天性黑蒙小鼠模型的视力恢复

期刊:Molecular Therapy-Methods & Clinical Development

影响因子:4.7

doi:10.1016/j.omtm.2025.101461

Lee Seok-Hoon, Wu Jun, Im Dongjoon, Hwang Gue-Ho, Jeong You Kyeong, Jiang Hui, Lee Seok Jae, Jo Dong Hyun, Goddard William A 3rd, Kim Jeong Hun, Bae Sangsu

Establishment and rescue of fibroblast cell lines carrying a nonsense mutation of RB1 by CRISPR-based base editing.

利用 CRISPR 碱基编辑技术建立和拯救携带 RB1 无义突变的成纤维细胞系

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-10600-2

Jung Youngri, Seo Eunhee, Yang Soyeon, Bae Sangsu, Kim Jeong Hun, Jang Hyeon-Ki, Jo Dong Hyun

细胞生物学

发表日期：2025

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Development of a prime editor with improved editing efficiency in Arabidopsis

拟南芥中一种具有更高编辑效率的初级编辑器的开发

期刊:Bmb Reports

影响因子:3.3

doi:10.5483/BMBRep.2024-0137

Jeong, Yeong Yeop; Hong, Cheljong; Han, Jun Hee; Bae, Sangsu; Seo, Pil Joon

发表日期：2025

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Identification of optimal adenine and cytosine base editors for genome editing in Arabidopsis and soybean

拟南芥和大豆基因组编辑中最佳腺嘌呤和胞嘧啶碱基编辑器的鉴定

期刊:Bmb Reports

影响因子:3.3

doi:10.5483/BMBRep.2024-0102

Jeong, Yeong Yeop; Han, Jun Hee; Yu, Jihyeon; Bae, Sangsu; Seo, Pil Joon

碱基编辑

发表日期：2025

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Evolution of Prime Editing: Enhancing Efficiency and Expanding Capacity

Prime 编辑技术的演进：提高效率和扩展容量

Neuronal mitochondrial disaggregase CLPB ameliorates Huntington's disease pathology in mice

神经元线粒体解聚酶CLPB可改善小鼠亨廷顿病病理

In vivo adenine base editing of mutant Galc gene ameliorates Krabbe disease progression

体内腺嘌呤碱基编辑突变型Galc基因可改善克拉伯病进展

Large DNA deletions occur during DNA repair at 20-fold lower frequency for base editors and prime editors than for Cas9 nucleases.

DNA修复过程中，碱基编辑器和启动子编辑器导致大片段DNA缺失的频率比Cas9核酸酶低20倍

A rational engineering strategy for structural dynamics modulation enables target specificity enhancement of the Cas9 nuclease

通过合理的结构动力学调控工程策略，可以提高Cas9核酸酶的靶向特异性。

Autophagy induction enhances homologous recombination-associated CRISPR-Cas9 gene editing.

自噬诱导增强同源重组相关的 CRISPR-Cas9 基因编辑

Bystander editing by adenine base editors impairs vision restoration in a mouse model of Leber congenital amaurosis.

旁观者通过腺嘌呤碱基编辑器进行的编辑会损害 Leber 先天性黑蒙小鼠模型的视力恢复

Establishment and rescue of fibroblast cell lines carrying a nonsense mutation of RB1 by CRISPR-based base editing.

利用 CRISPR 碱基编辑技术建立和拯救携带 RB1 无义突变的成纤维细胞系

Development of a prime editor with improved editing efficiency in Arabidopsis

拟南芥中一种具有更高编辑效率的初级编辑器的开发

Identification of optimal adenine and cytosine base editors for genome editing in Arabidopsis and soybean

拟南芥和大豆基因组编辑中最佳腺嘌呤和胞嘧啶碱基编辑器的鉴定