日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Creating MHC-Restricted Neoantigens with Covalent Inhibitors That Can Be Targeted by Immune Therapy

利用共价抑制剂构建可被免疫疗法靶向的MHC限制性新抗原

Takamitsu Hattori # ,Lorenzo Maso # ,Kiyomi Y Araki ,Akiko Koide ,James Hayman ,Padma Akkapeddi ,Injin Bang ,Benjamin G Neel ,Shohei Koide

Genome-wide CRISPR/Cas9 screens reveal shared and cell-specific mechanisms of resistance to SHP2 inhibition

全基因组 CRISPR/Cas9 筛选揭示了对 SHP2 抑制的共同和细胞特异性抗性机制

Wei Wei, Mitchell J Geer, Xinyi Guo, Igor Dolgalev, Neville E Sanjana, Benjamin G Neel

Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy

全基因组 CRISPR 筛选鉴定出多个可增强 KRASG12C 抑制剂功效的合成致死靶点

Suman Mukhopadhyay # ,Hsin-Yi Huang # ,Ziyan Lin ,Michela Ranieri ,Shuai Li ,Soumyadip Sahu ,Yingzhuo Liu ,Yi Ban ,Kayla Guidry ,Hai Hu ,Alfonso Lopez ,Fiona Sherman ,Yi Jer Tan ,Yeuan Ting Lee ,Amanda P Armstrong ,Igor Dolgalev ,Priyanka Sahu ,Tinghu Zhang ,Wenchao Lu ,Nathanael S Gray ,James G Christensen ,Tracy T Tang ,Vamsidhar Velcheti ,Alireza Khodadadi-Jamayran ,Kwok-Kin Wong ,Benjamin G Neel

Oxidized mC modulates synthetic lethality to PARP inhibitors for the treatment of leukemia

氧化型mC调节PARP抑制剂的合成致死性,用于治疗白血病

John P Brabson ,Tiffany Leesang ,Yoon Sing Yap ,Jingjing Wang ,Minh Q Lam ,Byron Fang ,Igor Dolgalev ,Daniela A Barbieri ,Victoria Strippoli ,Carolina P Bañuelos ,Sofia Mohammad ,Peter Lyon ,Sana Chaudhry ,Dane Donich ,Anna Swirski ,Evan Roberts ,Ivelisse Diaz ,Daniel Karl ,Helena Gomes Dos Santos ,Ramin Shiekhattar ,Benjamin G Neel ,Stephen D Nimer ,Ramiro E Verdun ,Daniel Bilbao ,Maria E Figueroa ,Luisa Cimmino

Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer

HER2+乳腺癌耐药持续细胞的个体发育和脆弱性

Chewei Anderson Chang #,Jayu Jen #,Shaowen Jiang,Azin Sayad,Arvind Singh Mer,Kevin R Brown,Allison M L Nixon,Avantika Dhabaria,Kwan Ho Tang,David Venet,Christos Sotiriou,Jiehui Deng,Kwok-Kin Wong,Sylvia Adams,Peter Meyn,Adriana Heguy,Jane A Skok,Aristotelis Tsirigos,Beatrix Ueberheide,Jason Moffat,Abhyudai Singh,Benjamin Haibe-Kains,Alireza Khodadadi-Jamayran,Benjamin G Neel

Combined Inhibition of SHP2 and CXCR1/2 Promotes Antitumor T-cell Response in NSCLC

SHP2 和 CXCR1/2 的联合抑制可促进 NSCLC 中的抗肿瘤 T 细胞反应

Kwan Ho Tang #, Shuai Li #, Alireza Khodadadi-Jamayran, Jayu Jen, Han Han, Kayla Guidry, Ting Chen, Yuan Hao, Carmine Fedele, John A Zebala, Dean Y Maeda, James G Christensen, Peter Olson, Argus Athanas, Cynthia A Loomis, Aristotelis Tsirigos, Kwok-Kin Wong #, Benjamin G Neel #

MMD-associated RNF213 SNPs encode dominant-negative alleles that globally impair ubiquitylation

MMD 相关的 RNF213 SNP 编码显性负等位基因,会全面损害泛素化

Abhishek Bhardwaj, Robert S Banh, Wei Zhang, Sachdev S Sidhu, Benjamin G Neel

Genetically Defined Syngeneic Mouse Models of Ovarian Cancer as Tools for the Discovery of Combination Immunotherapy

利用基因定义的同源卵巢癌小鼠模型作为发现联合免疫疗法的工具

Sonia Iyer ,Shuang Zhang ,Simge Yucel ,Heiko Horn ,Sean G Smith ,Ferenc Reinhardt ,Esmee Hoefsmit ,Bimarzhan Assatova ,Julia Casado ,Marie-Charlotte Meinsohn ,M Inmaculada Barrasa ,George W Bell ,Fernando Pérez-Villatoro ,Kaisa Huhtinen ,Johanna Hynninen ,Jaana Oikkonen ,Pamoda M Galhenage ,Shailja Pathania ,Paula T Hammond ,Benjamin G Neel ,Anniina Farkkila ,David Pépin ,Robert A Weinberg

Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian Cancer

用于开发卵巢癌联合疗法的基因定义同源类器官平台

Shuang Zhang ,Sonia Iyer ,Hao Ran ,Igor Dolgalev ,Shengqing Gu ,Wei Wei ,Connor J R Foster ,Cynthia A Loomis ,Narciso Olvera ,Fanny Dao ,Douglas A Levine ,Robert A Weinberg ,Benjamin G Neel

Selective and noncovalent targeting of RAS mutants for inhibition and degradation

选择性和非共价靶向 RAS 突变体进行抑制和降解

Kai Wen Teng, Steven T Tsai, Takamitsu Hattori, Carmine Fedele, Akiko Koide, Chao Yang, Xuben Hou, Yingkai Zhang, Benjamin G Neel, John P O'Bryan, Shohei Koide