ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function
ALS相关的KIF5A突变会消除自身抑制,导致毒性功能获得。
期刊:Cell Reports
影响因子:7.5
doi:10.1016/j.celrep.2022.110598
Desiree M Baron,Adam R Fenton,Sara Saez-Atienzar,Anthony Giampetruzzi,Aparna Sreeram,Shankaracharya,Pamela J Keagle,Victoria R Doocy,Nathan J Smith,Eric W Danielson,Megan Andresano,Mary C McCormack,Jaqueline Garcia,Valérie Bercier,Ludo Van Den Bosch,Jonathan R Brent,Claudia Fallini,Bryan J Traynor,Erika L F Holzbaur,John E Landers