Mutant p53 epigenetically rewires CXCL10 to promote CD8⁺ T-cell infiltration and enhance the anti-PD-1 response in advanced prostate cancer
突变型p53通过表观遗传机制重塑CXCL10,促进CD8⁺ T细胞浸润,并增强晚期前列腺癌中的抗PD-1反应。
期刊:Journal of Experimental & Clinical Cancer Research
影响因子:12.8
doi:10.1186/s13046-026-03672-z
Chen, Jia; Ge, Qintao; He, Jun; Bian, Zichen; Yu, Haoming; Li, Chun; Meng, Jialin; Yin, Shuiping; Hao, Zongyao; Liang, Chaozhao; Zhang, Meng
肿瘤
表观遗传
T细胞
肿瘤免疫
CXCL1
CD8
CXCL10
T细胞
细胞生物学
前列腺癌
PD-1
免疫/内分泌