日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV V2 apex broadly neutralizing antibody development.

Env抗体共同进化表明B细胞启动是HIV V2顶端广泛中和抗体发展的主要瓶颈。

Habib Rumi, Roark Ryan S, Li Hui, Connell Andrew Jesse, Hogarty Michael P, Wagh Kshitij, Wang Shuyi, Marchitto Lorie, Skelly Ashwin N, Carey John W, Sowers Kirsten J, Ayyanathan Kasirajan, Plante Samantha J, Bibollet-Ruche Frederic, Park Younghoon, Agostino Colby J, Singh Ajay, Martella Christian L, Lewis Emily, Rando Juliette M, Chohan Neha, Lora Jinery, Ding Wenge, Campion Mary S, Zhao Chengyan, Liu Weimin, Li Yingying, Li Xuduo, Liang Bo, Chowdhury Rohan Roy, Amereh Khaled, Van Itallie Elizabeth, Sheng Zizhang, Ghosh Amrit R, Bar Katharine J, Williams Wilton B, Wiehe Kevin, Saunders Kevin O, Edwards Robert J, Cain Derek W, Lewis Mark G, Batista Facundo D, Burton Dennis R, Andrabi Raiees, Kulp Daniel W, Haynes Barton F, Korber Bette, Shapiro Lawrence, Kwong Peter D, Hahn Beatrice H, Shaw George M

Early clonal dominance at priming sets the trajectory for broad HIV serum neutralization.

早期克隆优势决定了 HIV 血清中和的广泛进程。

Liang Bo, Zhu Yuxin, Roark Ryan S, Li Xuduo, Mishra Nitesh, Martella Christian L, Vo Anh L, Giese Gabriella, Huang Qin, Biju Andrea, Tjio Lifei, Chowdhury Rohan Roy, Oberoi Prabhgun, Amereh Khaled, Wani Areeba A, Zhang Yuexiu, Andrabi Sharaf, Sekar Tharunika V, Somanathan Anjali, Kassab Muzaffer, Nedellec Rebecca, Callaghan Sean, Avillion Gabriel, Lewis Mark G, Sackett Sara Dutton, Skelly Ashwin N, Bibollet-Ruche Frederic, Shapiro Lawrence, Sheng Zizhang, Briney Bryan, Hahn Beatrice H, Burton Dennis R, Irvine Darrell J, Kwong Peter D, Shaw George M, Andrabi Raiees

Structural and genetic basis of HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodies

恒河猴广谱中和抗体识别HIV-1包膜V2顶端的结构和遗传基础

Ryan S Roark #   ,Rumi Habib # ,Jason Gorman ,Hui Li,Andrew Jesse Connell,Mattia Bonsignori,Yicheng Guo,Michael P Hogarty,Adam S Olia,Kirsten J Sowers,Baoshan Zhang,Frederic Bibollet-Ruche,Tatsiana Bylund,Sean Callaghan,John W Carey,Gabriele Cerutti ,Darcy R Harris,Wanting He,Emily Lewis,Tracy Liu,Rosemarie D Mason,Yujie Qiao,Younghoon Park,Juliette M Rando,Ajay Singh,Jeremy J Wolff,Q Paula Lei,Mark K Louder,Raiees Andrabi ,Nicole A Doria-Rose,Kevin O Saunders   ,Michael S Seaman,Barton F Haynes ,Daniel W Kulp ,John R Mascola,Mario Roederer,Theodore C Pierson,Zizhang Sheng,Beatrice H Hahn,George M Shaw,Peter D Kwong ,Lawrence Shapiro

The HIV-1 envelope cytoplasmic tail protects infected cells from ADCC by downregulating CD4

HIV-1包膜胞质尾通过下调CD4来保护受感染细胞免受ADCC攻击。

Tauzin, Alexandra; Bélanger, Étienne; Prévost, Jérémie; Medjahed, Halima; Bourassa, Catherine; Bibollet-Ruche, Frederic; Richard, Jonathan; Hahn, Beatrice H; Finzi, Andrés

Plasmodium falciparum CyRPA Glycan Binding Does Not Explain Adaptation to Humans

恶性疟原虫 CyRPA 糖基化结合并不能解释其对人类的适应性。

Sharp, Paul M; Bibollet-Ruche, Frederic; Hahn, Beatrice H

Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV-1 V2 apex broadly neutralizing antibody development

Env抗体协同进化研究表明,B细胞启动是HIV-1 V2顶端广谱中和抗体产生的主要瓶颈。

Habib, Rumi; Roark, Ryan S; Li, Hui; Connell, Andrew Jesse; Hogarty, Michael P; Wagh, Kshitij; Wang, Shuyi; Marchitto, Lorie; Skelly, Ashwin N; Carey, John W; Sowers, Kirsten J; Ayyanathan, Kasirajan; Plante, Samantha J; Bibollet-Ruche, Frederic; Park, Younghoon; Agostino, Colby J; Singh, Ajay; Martella, Christian L; Lewis, Emily; Rando, Juliette M; Chohan, Neha; Lora, Jinery; Ding, Wenge; Campion, Mary S; Zhao, Chengyan; Liu, Weimin; Li, Yingying; Li, Xuduo; Liang, Bo; Chowdhury, Rohan Roy; Amereh, Khaled; Van Itallie, Elizabeth; Sheng, Zizhang; Ghosh, Amrit R; Bar, Katharine J; Williams, Wilton B; Wiehe, Kevin; Saunders, Kevin O; Edwards, Robert J; Cain, Derek W; Lewis, Mark; Batista, Facundo D; Burton, Dennis R; Andrabi, Raiees; Kulp, Daniel W; Haynes, Barton F; Korber, Bette; Shapiro, Lawrence; Kwong, Peter D; Hahn, Beatrice H; Shaw, George M

Structure-guided design of native-like HIV Env Single Chain Trimers for enhanced stability, immunogenicity, and versatile vaccine delivery

以结构为导向设计天然样HIV Env单链三聚体,以增强其稳定性、免疫原性和多功能疫苗递送系统

Li, Xuduo; Krishnamurthy, Ipsita; Mishra, Nitesh; James, Nicole E; Chowdhury, Rohan Roy; Callaghan, Sean; Somanathan, Anjali; Avillion, Gabriel; Amereh, Khaled; Sekar, Tharunika; Oberoi, Prabhgun; Zhu, Yuxin; Torres, Jonathan L; Lee, Wen-Hsin; Allen, Joel D; Liang, Bo; Giese, Gabriella; Vo, Anh L; Andrabi, Sharaf; Jain, Ishita; Mergiya, Asanti; Capozzola, Tazio; He, Wan-Ting; Anzanello, Fabio; Habib, Rumi; Bibollet-Ruche, Frederic; Nedellec, Rebecca; Sackett, Sara Dutton; Ozorowski, Gabriel; Burton, Dennis R; Hahn, Beatrice H; Shaw, George M; Ward, Andrew B; Crispin, Max; Barnes, Christopher O; Andrabi, Raiees

Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen Design

通过一种新型两步机制持续诱导广谱中和HIV抗体,为免疫原设计提供指导

Skelly, Ashwin N; Gristick, Harry B; Li, Hui; Gavor, Edem; Connell, Andrew J; Kreider, Edward F; Marchitto, Lorie; Hogarty, Michael P; Newby, Maddy L; Allen, Joel D; Liu, Weimin; West, Anthony P Jr; Ayyanathan, Kasirajan; Campion, Mary S; Winters, Kaitlyn; Gordon, Colette G; Osbaldeston, Rebecca A; Akeley, Macy J; Li, Yingying; Singh, Ajay; Cruickshank, Kendra; Park, Younghoon; Zhao, Chengyan; Li, Xuduo; Amereh, Khaled; Itallie, Elizabeth Van; Carey, John W; Albertus, Amie; DeLaitsch, Andrew T; Keeffe, Jennifer R; Lituchy, Melinda G; Walsh, Agnes A; Morris, Daniel J; Habib, Rumi; Bibollet-Ruche, Frederic; Mishra, Nitesh; Avillion, Gabriel; Koranda, Nicholas S; Plante, Samantha J; Martella, Christian L; Lora, Jinery; Wang, Eric J D; Lewis, Mark G; Martin, Malcolm A; Nussenzweig, Michel C; Seaman, Michael S; Irvine, Darrell J; Wiehe, Kevin J; Haynes, Barton F; Wagh, Kshitij; Korber, Bette T; Andrabi, Raiees; Crispin, Max; Weissman, Drew; Bjorkman, Pamela J; Hahn, Beatrice H; Shaw, George M

Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques.

针对种系 HIV 免疫原的免疫原可诱导非近交系猕猴产生交叉中和抗体。

Mishra Nitesh, Liang Bo, Roark Ryan S, Ghosh Amrit, Callaghan Sean, Lee Wen-Hsin, Li Xuduo, Vo Anh L, Avillion Gabriel, Chowdhury Rohan Roy, Habib Rumi H, Bibollet-Ruche Frederic, Giese Gabriella, Oberoi Prabhgun, Amereh Khaled, Somanathan Anjali, Zhu Yuxin, Zhang Yuexiu, Kassab Muzaffer, Tjio Lifei, Andrabi Sharaf, Reyes Raphael A, Allen Joel D, James Nicole E, Randall Kipchoge N Jr, van der Maas Lara, Ben-Akiva Elana, Kacmarek-Michaels Kasia, Plante Samantha, Martella Christian L, Skelly Ashwin N, Singh Ajay, Hurtado Jonathan, Dueker Katharina, Capozzola Tazio, Nedellec Rebecca, Ozorowski Gabriel, Lewis Mark M, Falcone Samantha, Carfi Andrea, Himansu Sunny, Shapiro Lawrence, Crispin Max, Hahn Beatrice H, Briney Bryan, Irvine Darrell J, Burton Dennis R, Ward Andrew B, Batista Facundo D, Kwong Peter D, Shaw George M, Andrabi Raiees

Single-cell transcriptomics identifies prothymosin α restriction of HIV-1 in vivo

单细胞转录组学鉴定出胸腺素α在体内对HIV-1的限制作用

Aviva Geretz ,Philip K Ehrenberg ,Robert J Clifford ,Alexandre Laliberté ,Caterina Prelli Bozzo ,Daina Eiser ,Gautam Kundu ,Lauren K Yum ,Richard Apps ,Matthew Creegan ,Mohamed Gunady ,Shida Shangguan ,Eric Sanders-Buell ,Carlo Sacdalan ,Nittaya Phanuphak ,Sodsai Tovanabutra ,Ronnie M Russell ,Frederic Bibollet-Ruche ,Merlin L Robb ,Nelson L Michael ,Julie A Ake ,Sandhya Vasan ,Denise C Hsu ,Beatrice H Hahn ,Frank Kirchhoff ,Rasmi Thomas