日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Profile of NT-0527, a brain penetrant NLRP3 Inflammasome inhibitor suitable as an in vivo tool compound for neuroinflammatory disorders.

NT-0527 是一种可穿透血脑屏障的 NLRP3 炎症小体抑制剂,适用于作为神经炎症性疾病的体内治疗药物

Harrison David, Billinton Andy, Bock Mark G, Clarke Nicholas P, Digby Zsofia, Gabel Christopher A, Lindsay Nicola, Reader Valérie, Scanlon Jane, Smolak Pamela, Thornton Peter, Wescott Heather, Watt Alan P

Pharmacological Analysis of NLRP3 Inflammasome Inhibitor Sodium [(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl][(1-methyl-1H-pyrazol-4-yl)({[(2S)-oxolan-2-yl]methyl})sulfamoyl]azanide in Cellular and Mouse Models of Inflammation Provides a Translational Framework.

在细胞和小鼠炎症模型中对 NLRP3 炎症小体抑制剂钠 [(1,2,3,5,6,7-六氢-s-茚满-4-基)氨基甲酰基][(1-甲基-1H-吡唑-4-基)({[(2S)-氧杂环戊烷-2-基]甲基})磺酰胺酰基]氮化物进行药理学分析,为转化应用提供了框架

Doedens John R, Smolak Pamela, Nguyen MyTrang, Wescott Heather, Diamond Christine, Schooley Ken, Billinton Andy, Harrison David, Koller Beverly H, Watt Alan P, Gabel Christopher A

Tau and Amyloid β Protein in Patient-Derived Aqueous Brain Extracts Act Concomitantly to Disrupt Long-Term Potentiation in Vivo

患者脑水提取物中的 Tau 和淀粉样 β 蛋白同时作用,破坏体内长期增强作用

Tomas Ondrejcak, Igor Klyubin, Neng-Wei Hu, Tiernan T O'Malley, Grant T Corbett, Róisín Winters, Michael S Perkinton, Andy Billinton, Jack A Prenderville, Dominic M Walsh, Michael J Rowan

Interlaboratory Study to Evaluate a Testing Protocol for the Safety of Food Packaging Coatings

评估食品包装涂层安全性测试方案的实验室间研究

Maricel Marin-Kuan, Vincent Pagnotti, Amaury Patin, Julie Moulin, Helia Latado, Jesús Varela, Yves-Alexis Hammel, Thomas Gude, Heidi Moor, Nick Billinton, Matthew Tate, Peter Alexander Behnisch, Harrie Besselink, Heather Burleigh-Flayer, Sander Koster, David T Szabo

Fracture-induced pain-like behaviours in a femoral fracture mouse model

股骨骨折小鼠模型中骨折引起的疼痛样行为

R Magnusdottir, S Gohin, F Ter Heegde, M Hopkinson, I F McNally, A Fisher, N Upton, A Billinton, C Chenu

PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins

PrP是可溶性神经退行性疾病致病蛋白聚集体介导的毒性作用的核心参与者。

Corbett, Grant T; Wang, Zemin; Hong, Wei; Colom-Cadena, Marti; Rose, Jamie; Liao, Meichen; Asfaw, Adhana; Hall, Tia C; Ding, Lai; DeSousa, Alexandra; Frosch, Matthew P; Collinge, John; Harris, David A; Perkinton, Michael S; Spires-Jones, Tara L; Young-Pearse, Tracy L; Billinton, Andrew; Walsh, Dominic M

Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease

对细胞外tau蛋白复杂性的了解有助于开发基于血液的阿尔茨海默病筛查方法

Chen, Zhicheng; Mengel, David; Keshavan, Ashvini; Rissman, Robert A; Billinton, Andrew; Perkinton, Michael; Percival-Alwyn, Jennifer; Schultz, Aaron; Properzi, Michael; Johnson, Keith; Selkoe, Dennis J; Sperling, Reisa A; Patel, Purvish; Zetterberg, Henrik; Galasko, Douglas; Schott, Jonathan M; Walsh, Dominic M

Anti-PrPC antibody rescues cognition and synapses in transgenic alzheimer mice

抗PrPC抗体可挽救转基因阿尔茨海默病小鼠的认知功能和突触功能。

Timothy O Cox ,Erik C Gunther ,A Harrison Brody ,Marius T Chiasseu ,Austin Stoner ,Levi M Smith ,Laura T Haas ,Jayne Hammersley ,Gareth Rees ,Bhupinder Dosanjh ,Maria Groves ,Matthew Gardener ,Claire Dobson ,Tristan Vaughan ,Iain Chessell ,Andrew Billinton ,Stephen M Strittmatter

Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways

细胞外单体和聚集的 Tau 通过重叠但不同的途径有效进入人类神经元

Lewis D Evans, Thomas Wassmer, Graham Fraser, James Smith, Michael Perkinton, Andrew Billinton, Frederick J Livesey

Central inhibition of granulocyte-macrophage colony-stimulating factor is analgesic in experimental neuropathic pain

中枢抑制粒细胞巨噬细胞集落刺激因子对实验性神经性疼痛有镇痛作用

Louise S C Nicol, Peter Thornton, Jon P Hatcher, Colin P Glover, Carl I Webster, Matthew Burrell, Kessia Hammett, Clare A Jones, Matthew A Sleeman, Andrew Billinton, Iain Chessell