日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural probing of RNA hairpins quantifies protein occupancy on RNA and links it to function in human cells

对RNA发夹结构进行结构探测可以量化RNA上的蛋白质结合情况,并将其与人类细胞的功能联系起来。

Thurm, Abby R; Nguyen, Tanya H; Campos, Jesus Damian Torres; Mansfield, Matthew; Bintu, Lacramioara; Hagler, Lauren D

Human Synthetic Biology and Programmable Gene Regulation Control

人类合成生物学和可编程基因调控

Thurm, Abby R; Janer Carattini, Geovanni L; Bintu, Lacramioara

Machine-guided dual-objective protein engineering for deimmunization and therapeutic functions.

利用机器引导的双目标蛋白质工程实现去免疫和治疗功能

Wolfsberg Eric, Paul Jean-Sebastien, Tycko Josh, Chen Binbin, Bassik Michael C, Bintu Lacramioara, Alizadeh Ash A, Gao Xiaojing J

Bifunctional transcriptional effector domains control gene expression pulses in an occupancy-dependent manner

双功能转录效应结构域以占位依赖的方式控制基因表达脉冲。

Andrews, Cecelia J; Costa, Eli J; Janer Carattini, Geovanni L; DelRosso, Nicole V; Fujimori, Taihei; Shimasawa, Masaru; Bintu, Lacramioara

Development of compact transcriptional effectors using high-throughput measurements in diverse contexts.

利用高通量测量在不同环境下开发紧凑型转录效应因子

Tycko Josh, Van Mike V, Aradhana, DelRosso Nicole, Ye Hanrong, Yao David, Valbuena Raeline, Vaughan-Jackson Alun, Xu Xiaoshu, Ludwig Connor, Spees Kaitlyn, Liu Katherine, Gu Mingxin, Khare Venya, Mukund Adi Xiyal, Suzuki Peter H, Arana Sophia, Zhang Catherine, Du Peter P, Ornstein Thea S, Hess Gaelen T, Kamber Roarke A, Qi Lei S, Khalil Ahmad S, Bintu Lacramioara, Bassik Michael C

The H3.3K36M oncohistone disrupts the establishment of epigenetic memory through loss of DNA methylation.

H3.3K36M 癌组蛋白通过 DNA 甲基化的丧失破坏表观遗传记忆的建立

Sinha Joydeb, Nickels Jan F, Thurm Abby R, Ludwig Connor H, Archibald Bella N, Hinks Michaela M, Wan Jun, Fang Dong, Bintu Lacramioara

High-throughput discovery of regulatory effector domains in human RNA-binding proteins

利用高通量方法发现人类RNA结合蛋白中的调控效应结构域

Thurm, Abby R; Finkel, Yaara; Andrews, Cecelia; Cai, Xiangmeng S; Benko, Colette; Bintu, Lacramioara

Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome project

基因组的空间和时间组织:4D核组计划的现状和未来目标

Dekker, Job; Alber, Frank; Aufmkolk, Sarah; Beliveau, Brian J; Bruneau, Benoit G; Belmont, Andrew S; Bintu, Lacramioara; Boettiger, Alistair; Calandrelli, Riccardo; Disteche, Christine M; Gilbert, David M; Gregor, Thomas; Hansen, Anders S; Huang, Bo; Huangfu, Danwei; Kalhor, Reza; Leslie, Christina S; Li, Wenbo; Li, Yun; Ma, Jian; Noble, William S; Park, Peter J; Phillips-Cremins, Jennifer E; Pollard, Katherine S; Rafelski, Susanne M; Ren, Bing; Ruan, Yijun; Shav-Tal, Yaron; Shen, Yin; Shendure, Jay; Shu, Xiaokun; Strambio-De-Castillia, Caterina; Vertii, Anastassiia; Zhang, Huaiying; Zhong, Sheng

Temporal signaling, population control, and information processing through chromatin-mediated gene regulation

染色质介导的基因调控实现时间信号传导、种群控制和信息处理

Mukund, Adi; Bintu, Lacramioara

The sound of silence: Transgene silencing in mammalian cell engineering

寂静之声:哺乳动物细胞工程中的转基因沉默

Cabrera, Alan; Edelstein, Hailey I; Glykofrydis, Fokion; Love, Kasey S; Palacios, Sebastian; Tycko, Josh; Zhang, Meng; Lensch, Sarah; Shields, Cara E; Livingston, Mark; Weiss, Ron; Zhao, Huimin; Haynes, Karmella A; Morsut, Leonardo; Chen, Yvonne Y; Khalil, Ahmad S; Wong, Wilson W; Collins, James J; Rosser, Susan J; Polizzi, Karen; Elowitz, Michael B; Fussenegger, Martin; Hilton, Isaac B; Leonard, Joshua N; Bintu, Lacramioara; Galloway, Kate E; Deans, Tara L