日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

SCN10A-short gene therapy to restore conduction and protect against malignant cardiac arrhythmias

SCN10A短基因疗法可恢复传导功能并预防恶性心律失常

Wang, Jianan; Verkerk, Arie O; Wilders, Ronald; Zhang, Yingnan; Zhang, Kelly; Prakosa, Adityo; Rivaud, Mathilde R; Marsman, E Madelief J; Boender, Arie R; Klerk, Mischa; Fokkert, Lianne; de Jonge, Berend; Neef, Klaus; Kirzner, Osne F; Bezzina, Connie R; Remme, Carol Ann; Tan, Hanno L; Boukens, Bastiaan J; Devalla, Harsha D; Trayanova, Natalia A; Christoffels, Vincent M; Barnett, Phil; Boink, Gerard J J

PITX2 dosage-dependent changes in pacemaker cell state underlie sinus node dysfunction and atrial arrhythmias.

PITX2 剂量依赖性地改变起搏细胞状态是窦房结功能障碍和心房心律失常的根本原因。

van der Maarel Lieve E, Mungroo M Ridwane, Mulleners Otto J, Rivaud Mathilde R, Verkerk Arie O, van Duijvenboden Karel, Tiel Groenestege Freek H T, Steimle Jeffrey D, Fokkert Lianne, de Gier-de Vries Corrie, Klerk Mischa, Boender Arie R, Martin James F, Jensen Bjarke, Boink Gerard J J, Devalla Harsha D, Christoffels Vincent M

Living myocardial slices as a model for testing cardiac pro-reparative gene therapies.

以活体心肌切片为模型,测试心脏促修复基因疗法

Caliandro Rocco, Husetić Azra, Ligtermoet Merel L, Boender Arie R, Zentilin Lorena, Boink Gerard J J, Giacca Mauro, Gladka Monika M

Cross-species comparison reveals that Hmga1 reduces H3K27me3 levels to promote cardiomyocyte proliferation and cardiac regeneration

跨物种比较表明,Hmga1通过降低H3K27me3水平来促进心肌细胞增殖和心脏再生。

Mara Bouwman # ,Dennis E M de Bakker # ,Hessel Honkoop ,Alexandra E Giovou ,Danielle Versteeg ,Arie R Boender ,Phong D Nguyen ,Merel Slotboom ,Daniel Colquhoun ,Marta Vigil-Garcia ,Lieneke Kooijman ,Rob Janssen ,Ingeborg B Hooijkaas ,Marie Günthel ,Kimberly J Visser ,Mischa Klerk ,Lorena Zentilin ,Mauro Giacca ,Jan Kaslin ,Gerard J J Boink ,Eva van Rooij ,Vincent M Christoffels ,Jeroen Bakkers

AAV6 vectors provide superior gene transfer compared to AAV9 vectors following intramyocardial administration.

与 AAV9 载体相比,AAV6 载体在心肌内注射后可提供更优的基因转移效果

Wang Jianan, Jonker Timo, Cervera-Barea Aina, Dong Zhenyu, Visser Ruud N, Birza Evelien E, Boender Arie R, Klerk Mischa, Yang Yuting, Visser Joyce, Jansen Marlijn S, Grootswagers Tom C, Bart Cindy I, de Jager Saskia C A, Schrödel Silke, Thirion Christian, Kirzner Osne F, Tan Hanno L, de Vries Antoine A F, Sluijter Joost P G, Neef Klaus, de Groot Joris R, Christoffels Vincent M, Boink Gerard J J

Arrhythmogenic Cardiomyopathy: Towards Genotype Based Diagnoses and Management

致心律失常性心肌病:迈向基于基因型的诊断和管理

Muller, Steven A; Bertoli, Giorgia; Wang, Jianan; Gasperetti, Alessio; Cox, Moniek G P J; Calkins, Hugh; Riele, Anneline S J M Te; Judge, Daniel P; Delmar, Mario; Hauer, Richard N W; Boink, Gerard J J; Cerrone, Marina; Tintelen, J Peter van; James, Cynthia A

Human Cardiac Microtissues Display Improved Engraftment and Survival in a Porcine Model of Myocardial Infarction

人类心脏微组织在猪心肌梗死模型中显示出更高的移植成功率和存活率

Demkes, Evelyne; Cervera-Barea, Aina; Ebner-Peking, Patricia; Wolf, Martin; Hochmann, Sarah; Scheren, Amy S; Bijsterveld, Mayke; van Oostveen, C Marlies; Jansen, Marlijn; Visser, Joyce; Triebert, Wiebke; Halloin, Caroline; Dobbe, Johannes G G; de Vos, Judith; Schürz, Melanie; Danmayr, Joachim; Aalders, Maurice C G; Boink, Gerard J J; Neef, Klaus; Strunk, Dirk; Zweigerdt, Robert; de Jager, Saskia C A; Sluijter, Joost P G

Modeling the atrioventricular conduction axis using human pluripotent stem cell-derived cardiac assembloids

利用人类多能干细胞衍生的心脏类器官构建房室传导轴模型

Jiuru Li ,Alexandra Wiesinger ,Lianne Fokkert ,Priscilla Bakker ,Dylan K de Vries ,Anke J Tijsen ,Yigal M Pinto ,Arie O Verkerk ,Vincent M Christoffels ,Gerard J J Boink ,Harsha D Devalla

Automatic measurement of short-term variability of repolarization to indicate ventricular arrhythmias in a porcine model of cardiac ischaemia

在猪心肌缺血模型中,通过自动测量短期复极变异性来指示室性心律失常

Loen, Vera; Smoczynska, Agnieszka; Aranda Hernandez, Alfonso; Scheerder, Coert O S; van der Linde, Britt H R; Beekman, Henriëtte D M; Cervera-Barea, Aina; Boink, Gerard J J; Sluijter, Joost P G; van der Heyden, Marcel A G; Meine, Mathias; Vos, Marc A

Role of Genetic Variation in Transcriptional Regulatory Elements in Heart Rhythm

基因变异在心律转录调控元件中的作用

Jonker, Timo; Barnett, Phil; Boink, Gerard J J; Christoffels, Vincent M