日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial

长期使用gantenerumab治疗显性遗传性阿尔茨海默病的安全性和有效性:一项2/3期多中心、随机、双盲、安慰剂对照平台DIAN-TU试验的开放标签扩展研究

Bateman, Randall J; Li, Yan; McDade, Eric M; Llibre-Guerra, Jorge J; Clifford, David B; Atri, Alireza; Mills, Susan L; Santacruz, Anna M; Wang, Guoqiao; Supnet, Charlene; Benzinger, Tammie L S; Gordon, Brian A; Ibanez, Laura; Klein, Gregory; Baudler, Monika; Doody, Rachelle S; Delmar, Paul; Kerchner, Geoffrey A; Bittner, Tobias; Wojtowicz, Jakub; Bonni, Azad; Fontoura, Paulo; Hofmann, Carsten; Kulic, Luka; Hassenstab, Jason; Aschenbrenner, Andrew J; Perrin, Richard J; Cruchaga, Carlos; Renton, Alan E; Xiong, Chengjie; Goate, Alison A; Morris, John C; Holtzman, David M; Snider, B Joy; Mummery, Catherine; Brooks, William S; Wallon, David; Berman, Sarah B; Roberson, Erik; Masters, Colin L; Galasko, Douglas R; Jayadev, Suman; Sanchez-Valle, Rachel; Pariente, Jeremie; Kinsella, Justin; van Dyck, Christopher H; Gauthier, Serge; Hsiung, Ging-Yuek Robin; Masellis, Mario; Dubois, Bruno; Honig, Lawrence S; Jack, Clifford R; Daniels, Alisha; Aguillón, David; Allegri, Ricardo; Chhatwal, Jasmeer; Day, Gregory; Fox, Nick C; Huey, Edward; Ikeuchi, Takeshi; Jucker, Mathias; Lee, Jae-Hong; Levey, Allan I; Levin, Johannes; Lopera, Francisco; Roh, JeeHoon; Rosa-Neto, Pedro; Schofield, Peter R

Angelman syndrome patient-derived neuron screen leads to clinical ASO rugonersen targeting UBE3A-ATS with long-lasting effect in monkeys.

安格曼综合征患者来源的神经元筛选产生了临床 ASO rugonersen,该药物靶向 UBE3A-ATS,在猴子身上具有持久疗效

Jagasia Ravi, Bon Charlotte, Rasmussen Soren V, Badillo Solveig, Tehler Disa, Buchy Danièle, Berrera Marco, Prasad Megana, Chamberlain Stormy, Terrigno Marco, Pandya Nikhil J, Costa Veronica, Wang Congwei, Pedersen Lykke, Miller Meghan T, Erichsen Kamille Dumong, Joenson Lars, Patsch Christoph, Hipp Joerg F, Bonni Azad, Müller Lutz, Braendli-Baiocco Annamaria, Kremer Thomas, Koller Erich, Hoener Marius C

Time-to-event analysis mitigates the impact of symptomatic therapy on therapeutic benefit in Parkinson's disease trials

生存分析可以减轻对症治疗对帕金森病试验疗效的影响。

Pagano, Gennaro; Trundell, Dylan; Simuni, Tanya; Pavese, Nicola; Marek, Kenneth; Postuma, Ronald B; Shariati, Nima; Monnet, Annabelle; Moore, Emma; Davies, Evan W; Svoboda, Hanno; Pross, Nathalie; Bonni, Azad; Nikolcheva, Tania

Author Correction: Time-to-event analysis mitigates the impact of symptomatic therapy on therapeutic benefit in Parkinson's disease trials

作者更正:生存分析可以减轻对症治疗对帕金森病试验疗效的影响。

Pagano, Gennaro; Trundell, Dylan; Simuni, Tanya; Pavese, Nicola; Marek, Kenneth; Postuma, Ronald B; Shariati, Nima; Monnet, Annabelle; Moore, Emma; Davies, Evan W; Svoboda, Hanno; Pross, Nathalie; Bonni, Azad; Nikolcheva, Tania

Corrigendum: Identification of a PTEN-regulated STAT(3) brain tumor suppressor pathway

更正:PTEN调控的STAT(3)脑肿瘤抑制通路鉴定

de la Iglesia, Núria; Konopka, Genevieve; Puram, Sidharth V; Chan, Jennifer A; Bachoo, Robert M; You, Mingjian J; Levy, David E; DePinho, Ronald A; Bonni, Azad

The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway.

郝方丹综合征蛋白 USP7 通过一种新型的不依赖于 p53 的泛素信号通路调节大脑中的神经元连接

Chen Hao, Ferguson Cole J, Mitchell Dylan C, Risch Isabel, Titus Amanda, Paulo Joao A, Hwang Andrew, Beck Loren K, Lin Tsen-Hsuan, Gu Wei, Song Sheng-Kwei, Yuede Carla M, Yano Hiroko, Griffith Obi L, Griffith Malachi, Gygi Steven P, Bonni Azad, Kim Albert H

Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU Trial

长期使用gantenerumab治疗显性遗传性阿尔茨海默病的安全性和有效性:一项开放标签扩展的2/3期多中心、随机、双盲、安慰剂对照平台DIAN-TU试验

Bateman, Randall J; Li, Yan; McDade, Eric M; Llibre-Guerra, Jorge J; Clifford, David B; Atri, Alireza; Mills, Susan L; Santacruz, Anna M; Wang, Guoqiao; Supnet, Charlene; Benzinger, Tammie L S; Gordon, Brian A; Ibanez, Laura; Klein, Gregory; Baudler, Monika; Doody, Rachelle S; Delmar, Paul; Kerchner, Geoffrey A; Bittner, Tobias; Wojtowicz, Jakub; Bonni, Azad; Fontoura, Paulo; Hofmann, Carsten; Kulic, Luka; Hassenstab, Jason; Aschenbrenner, Andrew J; Perrin, Richard J; Cruchaga, Carlos; Renton, Alan E; Xiong, Chengjie; Goate, Alison A; Morris, John C; Holtzman, David M; Snider, B Joy; Mummery, Catherine; Brooks, William S; Wallon, David; Berman, Sarah B; Roberson, Erik; Masters, Colin L; Galasko, Douglas R; Jayadev, Suman; Sanchez-Valle, Rachel; Pariente, Jeremie; Kinsella, Justin; van Dyck, Christopher H; Gauthier, Serge; Robin Hsiung, Ging-Yuek; Masellis, Mario; Dubois, Bruno; Honig, Lawrence S; Jack, Clifford R; Daniels, Alisha; Aguillón, David; Allegri, Ricardo; Chhatwal, Jasmeer; Day, Gregory; Fox, Nick; Huey, Edward; Ikeuchi, Takeshi; Jucker, Mathias; Lee, Jae-Hong; Levey, Allan I; Levin, Johannes; Lopera, Francisco; Roh, JeeHoon; Rosa-Neto, Pedro; Schofield, Peter R

Prasinezumab slows motor progression in rapidly progressing early-stage Parkinson's disease

普拉西珠单抗可减缓快速进展型早期帕金森病患者的运动功能进展

Pagano, Gennaro; Taylor, Kirsten I; Anzures Cabrera, Judith; Simuni, Tanya; Marek, Kenneth; Postuma, Ronald B; Pavese, Nicola; Stocchi, Fabrizio; Brockmann, Kathrin; Svoboda, Hanno; Trundell, Dylan; Monnet, Annabelle; Doody, Rachelle; Fontoura, Paulo; Kerchner, Geoffrey A; Brundin, Patrik; Nikolcheva, Tania; Bonni, Azad

Sustained effect of prasinezumab on Parkinson's disease motor progression in the open-label extension of the PASADENA trial

在 PASADENA 试验的开放标签扩展研究中,普拉西珠单抗对帕金森病运动进展的持续疗效

Pagano, Gennaro; Monnet, Annabelle; Reyes, Adriana; Ribba, Benjamin; Svoboda, Hanno; Kustermann, Thomas; Simuni, Tanya; Postuma, Ronald B; Pavese, Nicola; Stocchi, Fabrizio; Brockmann, Kathrin; Smigorski, Krzysztof; Gerbaldo, Valentina; Fontoura, Paulo; Doody, Rachelle; Kerchner, Geoffrey A; Brundin, Patrik; Marek, Kenneth; Bonni, Azad; Nikolcheva, Tania

Correction: PIAS1 and TIF1γ collaborate to promote SnoN SUMOylation and suppression of epithelial-mesenchymal transition

更正:PIAS1 和 TIF1γ 协同促进 SnoN 的 SUMO 化修饰并抑制上皮-间质转化。

Chanda, Ayan; Ikeuchi, Yoshiho; Karve, Kunal; Sarkar, Anusi; Chandhoke, Amrita Singh; Deng, Lili; Bonni, Azad; Bonni, Shirin