日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Targeting STE20-type kinase MST3 improves metabolic dysfunction-associated steatohepatitis without affecting hepatocellular carcinoma development in mice

靶向STE20型激酶MST3可改善小鼠代谢功能障碍相关的脂肪性肝炎，且不影响肝细胞癌的发生发展。

期刊:BMC Medicine
影响因子:8.3
doi:10.1186/s12916-026-04812-0
Zhang, Jingjing; Gongye, Xiangdong; Kovooru, Lohitesh; Andersson, Emma; Asiedu, Bernice; Amrutkar, Manoj; Gul, Nadia; Myers, Caitlyn; Booten, Sheri; Lind, Dan Emil; Xia, Ying; Molinaro, Antonio; Härtlova, Anetta; Lindahl, Per; Murray, Sue; Mahlapuu, Margit
肿瘤
肿瘤免疫
信号转导
多发性硬化症
代谢
细胞生物学
肝炎
发表日期：2026
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Inhibition of GCKIII kinases STK25 and MST3 mitigates organ lipotoxicity and enhances metabolic resilience under nutritional stress

抑制GCKIII激酶STK25和MST3可减轻器官脂毒性，并增强营养应激下的代谢韧性。

期刊:BMC Medicine
影响因子:8.3
doi:10.1186/s12916-025-04359-6
Andersson, Emma; Gongye, Xiangdong; Cansby, Emmelie; Zhang, Jingjing; Caputo, Mara; Asiedu, Bernice; Garellick, Viktor; Booten, Sheri; Murray, Sue; Font-Gironès, Ferran; Ruud, Johan; Lind, Dan Emil; Amrutkar, Manoj; Howell, Brian W; Wernstedt Asterholm, Ingrid; Mahlapuu, Margit
信号转导
多发性硬化症
代谢
STK25
毒理研究
发表日期：2025
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Therapeutic Potential of STE20-Type Kinase STK25 Inhibition for the Prevention and Treatment of Metabolically Induced Hepatocellular Carcinoma

STE20型激酶STK25抑制剂在预防和治疗代谢性肝细胞癌中的治疗潜力

期刊:
影响因子:7.1
doi:PMC12022666
Ying Xia，Mara Caputo，Emma Andersson，Bernice Asiedu，Jingjing Zhang，Wei Hou，Manoj Amrutkar，Emmelie Cansby，Nadia Gul，Anne Gemmink，Caitlyn Myers，Mariam Aghajan，Sheri Booten，Andrew J Hoy，Anetta Härtlova，Per Lindahl，Anders Ståhlberg，Gert Schaart，Matthijs K C Hesselink，Andreas Peter，Sue Murray，Margit Mahlapuu
肝癌
细胞生物学
代谢
肿瘤
STK25
发表日期：2025
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Therapeutic Potential of STE20-Type Kinase STK25 Inhibition for the Prevention and Treatment of Metabolically Induced Hepatocellular Carcinoma

STE20型激酶STK25抑制剂在预防和治疗代谢性肝细胞癌中的治疗潜力

期刊:Cellular and Molecular Gastroenterology and Hepatology
影响因子:7.1
doi:10.1016/j.jcmgh.2025.101485
Ying Xia ，Mara Caputo ，Emma Andersson ，Bernice Asiedu ，Jingjing Zhang ，Wei Hou ，Manoj Amrutkar ，Emmelie Cansby ，Nadia Gul ，Anne Gemmink ，Caitlyn Myers ，Mariam Aghajan ，Sheri Booten ，Andrew J Hoy ，Anetta Härtlova ，Per Lindahl ，Anders Ståhlberg ，Gert Schaart ，Matthijs K C Hesselink ，Andreas Peter ，Sue Murray ，Margit Mahlapuu
信号转导
细胞生物学
肿瘤
肿瘤免疫
代谢
STK25
发表日期：2025
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Antisense oligonucleotides ameliorate kidney dysfunction in podocyte-specific APOL1 risk variant mice

反义寡核苷酸可改善足细胞特异性 APOL1 风险变异小鼠的肾功能障碍

期刊:Molecular Therapy
影响因子:12.1
doi:10.1016/j.ymthe.2022.04.007
Ya-Wen Yang, Bibek Poudel, Julia Frederick, Poonam Dhillon, Rojesh Shrestha, Ziyuan Ma, Junnan Wu, Koji Okamoto, Jeffrey B Kopp, Sheri L Booten, Danielle Gattis, Andrew T Watt, Matthew Palmer, Mariam Aghajan, Katalin Susztak
细胞生物学
其它细胞
发表日期：2022
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Ligand conjugated antisense oligonucleotide for the treatment of transthyretin amyloidosis: preclinical and phase 1 data

用于治疗转甲状腺素蛋白淀粉样变性的配体偶联反义寡核苷酸：临床前和 I 期数据

期刊:Esc Heart Failure
影响因子:3.7
doi:10.1002/ehf2.13154
Viney, Nicholas J; Guo, Shuling; Tai, Li-Jung; Baker, Brenda F; Aghajan, Mariam; Jung, Shiangtung W; Yu, Rosie Z; Booten, Sheri; Murray, Heather; Machemer, Todd; Burel, Sebastien; Murray, Sue; Buchele, Gustavo; Tsimikas, Sotirios; Schneider, Eugene; Geary, Richard S; Benson, Merrill D; Monia, Brett P
免疫/内分泌
发表日期：2021
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Correcting β-thalassemia by combined therapies that restrict iron and modulate erythropoietin activity

通过限制铁摄入和调节促红细胞生成素活性的联合疗法来纠正β-地中海贫血

期刊:Blood
影响因子:23.1
doi:10.1182/blood.2019004719
Casu, Carla; Pettinato, Mariateresa; Liu, Alison; Aghajan, Mariam; Lo Presti, Vania; Lidonnici, Maria Rosa; Munoz, Kevin A; O'Hara, Emir; Olivari, Violante; Di Modica, Simona Maria; Booten, Sheri; Guo, Shuling; Neil, Garry; Miari, Reem; Shapir, Nir; Zafir-Lavie, Inbal; Domev, Hagit; Ferrari, Giuliana; Sitara, Despina; Nai, Antonella; Rivella, Stefano
红细胞
细胞生物学
贫血
代谢
发表日期：2020
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Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease

将 Stk25 反义寡核苷酸靶向递送至肝细胞可保护小鼠免受非酒精性脂肪肝疾病的侵害

期刊:Cellular and Molecular Gastroenterology and Hepatology
影响因子:7.1
doi:10.1016/j.jcmgh.2018.12.004
Emmelie Cansby, Esther Nuñez-Durán, Elin Magnusson, Manoj Amrutkar, Sheri L Booten, Nagaraj M Kulkarni, L Thomas Svensson, Jan Borén, Hanns-Ulrich Marschall, Mariam Aghajan, Margit Mahlapuu
代谢
脂肪肝
其它细胞
WB
ACTC
发表日期：2019
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Antisense oligonucleotide treatment ameliorates IFN-γ-induced proteinuria in APOL1-transgenic mice

反义寡核苷酸治疗可改善 APOL1 转基因小鼠中 IFN-γ 诱导的蛋白尿

期刊:JCI Insight
影响因子:6.3
doi:10.1172/jci.insight.126124
Mariam Aghajan, Sheri L Booten, Magnus Althage, Christopher E Hart, Anette Ericsson, Ingela Maxvall, Joseph Ochaba, Angela Menschik-Lundin, Judith Hartleib, Steven Kuntz, Danielle Gattis, Christine Ahlström, Andrew T Watt, Jeffery A Engelhardt, Brett P Monia, Maria Chiara Magnone, Shuling Guo
信号转导
IHC
Goat
IgG
发表日期：2019
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Serine/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in mice

丝氨酸/苏氨酸蛋白激酶25反义寡核苷酸治疗可逆转小鼠的葡萄糖耐受不良、胰岛素抵抗和非酒精性脂肪肝疾病。

期刊:Hepatology Communications
影响因子:4.6
doi:10.1002/hep4.1128
Nuñez-Durán, Esther; Aghajan, Mariam; Amrutkar, Manoj; Sütt, Silva; Cansby, Emmelie; Booten, Sheri L; Watt, Andrew; Ståhlman, Marcus; Stefan, Norbert; Häring, Hans-Ulrich; Staiger, Harald; Borén, Jan; Marschall, Hanns-Ulrich; Mahlapuu, Margit
代谢
信号转导
脂肪肝
免疫/内分泌
发表日期：2018
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