日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

snRNA-seq of human cutaneous neurofibromas before and after selumetinib treatment implicates role of altered Schwann cell states, inter-cellular signaling, and extracellular matrix in treatment response

人类皮肤神经纤维瘤在接受司美替尼治疗前后的 snRNA-seq 提示改变的施万细胞状态、细胞间信号传导和细胞外基质在治疗反应中的作用

Cameron Church #, Christian X Fay #, Emil Kriukov, Hui Liu, Ashley Cannon, Lauren Ashley Baldwin, David K Crossman, Bruce Korf, Margaret R Wallace, Andrea M Gross, Brigitte C Widemann, Robert A Kesterson, Petr Baranov, Deeann Wallis

MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors

MEK 抑制剂与 TYK2 抑制剂在 NF1 相关恶性周围神经鞘瘤中发挥协同作用

Dana C Borcherding, Neha V Amin, Kevin He, Xiaochun Zhang, Yang Lyu, Carina Dehner, Himanshi Bhatia, Angad Gothra, Layla Daud, Peter Ruminski, Christine A Pratilas, Kai Pollard, Taylor Sundby, Brigitte C Widemann, Angela C Hirbe

Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor

单细胞测序揭示PRC2缺陷型恶性周围神经鞘瘤中核心转录因子的激活

Xiyuan Zhang,Hannah E Lou,Vishaka Gopalan,Zhihui Liu,Hilda M Jafarah,Haiyan Lei,Paige Jones,Carly M Sayers,Marielle E Yohe,Prashant Chittiboina,Brigitte C Widemann,Carol J Thiele,Michael C Kelly,Sridhar Hannenhalli,Jack F Shern

Cabozantinib for neurofibromatosis type 1-related plexiform neurofibromas: a phase 2 trial

卡博替尼治疗 1 型神经纤维瘤病相关丛状神经纤维瘤:一项 2 期临床试验

Michael J Fisher #, Chie-Schin Shih #, Steven D Rhodes, Amy E Armstrong, Pamela L Wolters, Eva Dombi, Chi Zhang, Steven P Angus, Gary L Johnson, Roger J Packer, Jeffrey C Allen, Nicole J Ullrich, Stewart Goldman, David H Gutmann, Scott R Plotkin, Tena Rosser, Kent A Robertson, Brigitte C Widemann, A

Selumetinib normalizes Ras/MAPK signaling in clinically relevant neurofibromatosis type 1 minipig tissues in vivo

司美替尼在体内使临床相关的 1 型神经纤维瘤病小型猪组织中的 Ras/MAPK 信号传导正常化

Sara H Osum, Alexander W Coutts, Dylan J Duerre, Barbara R Tschida, Mark N Kirstein, James Fisher, W Robert Bell, Oona Delpuech, Paul D Smith, Brigitte C Widemann, Christopher L Moertel, David A Largaespada, Adrienne L Watson

A molecular basis for neurofibroma-associated skeletal manifestations in NF1

NF1 中神经纤维瘤相关骨骼表现的分子基础

Yun Ma, Andrea M Gross, Eva Dombi, Alexander Pemov, Kwangmin Choi, Katherine Chaney, Steven D Rhodes, Steven P Angus, Noah Sciaky, D Wade Clapp, Nancy Ratner, Brigitte C Widemann, Jonathan J Rios, Florent Elefteriou

Pharmacodynamic Study of Miransertib in Individuals with Proteus Syndrome

Miransertib 对 Proteus 综合征患者的药效学研究

Kim M Keppler-Noreuil, Julie C Sapp, Marjorie J Lindhurst, Thomas N Darling, Jasmine Burton-Akright, Mohammadhadi Bagheri, Eva Dombi, Ashlyn Gruber, Paul F Jarosinski, Staci Martin, Neera Nathan, Scott M Paul, Ronald E Savage, Pamela L Wolters, Brian Schwartz, Brigitte C Widemann, Leslie G Biesecker

Severe Hepatotoxicity of Mithramycin Therapy Caused by Altered Expression of Hepatocellular Bile Transporters

肝细胞胆汁转运蛋白表达改变导致米特拉霉素治疗严重肝毒性

Tristan M Sissung, Phoebe A Huang, Ralph J Hauke, Edel M McCrea, Cody J Peer, Roberto H Barbier, Jonathan D Strope, Ariel M Ley, Mary Zhang, Julie A Hong, David Venzon, Jonathan P Jackson, Kenneth R Brouwer, Patrick Grohar, Jon Glod, Brigitte C Widemann, Theo Heller, David S Schrump, William D Figg

Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1

基因工程小型猪模拟人类 1 型神经纤维瘤病的主要临床特征

Sara H Isakson, Anthony E Rizzardi, Alexander W Coutts, Daniel F Carlson, Mark N Kirstein, James Fisher, Jeremie Vitte, Kyle B Williams, G Elizabeth Pluhar, Sonika Dahiya, Brigitte C Widemann, Eva Dombi, Tilat Rizvi, Nancy Ratner, Ludwine Messiaen, Anat O Stemmer-Rachamimov, Scott C Fahrenkrug, Davi

Sequence-Specific Pharmacokinetic and Pharmacodynamic Phase I/Ib Study of Olaparib Tablets and Carboplatin in Women's Cancer

奥拉帕尼片和卡铂在女性癌症中的序列特异性药代动力学和药效学 I/Ib 期研究

Jung-Min Lee, Cody J Peer, Minshu Yu, Lauren Amable, Nicolas Gordon, Christina M Annunziata, Nicole Houston, Andrew K L Goey, Tristan M Sissung, Bernard Parker, Lori Minasian, Victoria L Chiou, Robert F Murphy, Brigitte C Widemann, William D Figg, Elise C Kohn