日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape.

限制内体损伤感知可减少脂质纳米颗粒内体逃逸引发的炎症

Omo-Lamai Serena, Wang Yufei, Patel Manthan N, Milosavljevic Aleksa, Zuschlag Daniel, Poddar Subhajit, Wu Jichuan, Wang Liuqian, Dong Fengyi, Espy Carolann, Majumder Aparajeeta, Essien Eno-Obong, Shen Mengwen, Channer Breana, Papp Tyler E, Tobin Michael, Maheshwari Rhea, Jeong Sumin, Patel Sofia, Shah Anit, Murali Shruthi, Chase Liam S, Zamora Marco E, Arral Mariah L, Marcos-Contreras Oscar A, Myerson Jacob W, Hunter Christopher A, Discher Dennis, Gaskill Peter J, Tsourkas Andrew, Muzykantov Vladimir R, Brodsky Igor, Shin Sunny, Whitehead Kathryn A, Parhiz Hamideh, Katzen Jeremy, Miner Jonathan J, Trauner Dirk, Brenner Jacob S

Forward genetic screening in engineered colorectal cancer organoids identifies regulators of metastasis

利用工程化结直肠癌类器官进行正向基因筛选,鉴定出转移调控因子

Wang, Xin; Cramer, Zvi; Leu, Nicolae Adrian; Monaghan, Keara; Durning, Kayla; Adams-Tzivelekidis, Stephanie; Rhoades, Joshua H; Heintz, Jonathan; Tian, Yuhua; Rico, Joshua; Mendez, Diego; Petroni, Ricardo; King, Austin C; Kim, Melissa S; Matsuda, Rina; Hanselman, Olivia; Shin, Alice E; Carrera Rodríguez, María F; Brodsky, Igor E; Rustgi, Anil; Li, Ning; Lengner, Christopher J; Andrés Blanco, M

TNF signaling maintains local restriction of bacterial founder populations in intestinal and systemic sites during oral Yersinia infection

在口服耶尔森菌感染期间,TNF信号通路维持肠道和全身部位细菌创始种群的局部限制。

Peterson, Stefan T; Dailey, Katherine G; Hullahalli, Karthik; Sorobetea, Daniel; Matsuda, Rina; Sewell, Jaydeen; Yost, Winslow; O'Neill, Rosemary; Bobba, Suhas; Apenes, Nicolai; Sherman, Matthew E; Balazs, George I; Assenmacher, Charles-Antoine; Cox, Arin; Lanza, Matthew; Shin, Sunny; Waldor, Matthew K; Brodsky, Igor E

A Potent Inhibitor of Caspase‑8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases.

基于 IL-18 四肽序列的强效 Caspase-8 抑制剂揭示了炎症和凋亡起始 Caspase 之间的共同特异性

Bourne Christopher M, Raniszewski Nicole R, Mahale Ashutosh B, Kulkarni Madhura, Exconde Patrick M, Liu Sherry, Yost Winslow, Wrong Tristan J, Patio Robert C, Kardhashi Matilda, Shosanya Teni, Kambayashi Mirai, Discher Bohdana M, Brodsky Igor E, Burslem George M, Taabazuing Cornelius Y

Innate detection of Salmonella replication triggers caspase-8-dependent apoptosis via TLR-driven TNF signaling and NLRC4-mediated sensing of the SPI-2 Type III secretion system

先天性检测沙门氏菌复制可通过TLR驱动的TNF信号通路和NLRC4介导的SPI-2 III型分泌系统感知触发caspase-8依赖性细胞凋亡。

Herrmann, Beatrice I; Zamba-Campero, Maxime; Garcia-Sillas, Reyna; Yost, Winslow W; Peterson, Lance W; Roncaioili, Justin L; Rankin, Shelley C; Schifferli, Dieter M; Ravichandran, Kodi; Brodsky, Igor E

Diverse infections transcriptionally reprogram the intestinal epithelium and epithelial-immune cell interactions

多种感染可转录重编程肠道上皮细胞和上皮细胞-免疫细胞相互作用。

Hart, Andrew; Merolle, Maria; Howard, Christian; Haskins, Breanne E; Cohn, Ian S; Bobba, Suhas; Xiao, Rui; Yang, Yi; Cadwell, Ken; Ma, Junjie; Yano, Hiroshi; Hou, Xiaoxiao; Wallbank, Bethan A; Cutillo, Daniel; Ivanov, Ivaylo I; Striepen, Boris; Shin, Sunny; Brodsky, Igor E; Artis, David; Hunter, Christopher A; Beiting, Daniel P

Chemical Tools Based on the Tetrapeptide Sequence of IL-18 Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases.

基于IL-18四肽序列的化学工具揭示了炎症和凋亡起始半胱天冬酶之间的共同特异性

Bourne Christopher M, Raniszewski Nicole R, Kulkarni Madhura, Exconde Patrick M, Liu Sherry, Yost Winslow, Wrong Tristan J, Patio Robert C, Mahale Ashutosh, Kardhashi Matilda, Shosanya Teni, Kambayashi Mirai, Discher Bohdana M, Brodsky Igor E, Burslem George M, Taabazuing Cornelius Y

A TNF-IL-1 circuit controls Yersinia within intestinal pyogranulomas

TNF-IL-1通路控制肠道化脓性肉芽肿内的耶尔森菌

Matsuda, Rina; Sorobetea, Daniel; Zhang, Jenna; Peterson, Stefan T; Grayczyk, James P; Yost, Winslow; Apenes, Nicolai; Kovalik, Maria E; Herrmann, Beatrice; O'Neill, Rosemary J; Bohrer, Andrea C; Lanza, Matthew; Assenmacher, Charles-Antoine; Mayer-Barber, Katrin D; Shin, Sunny; Brodsky, Igor E

Cryptosporidium impacts epithelial turnover and is resistant to induced death of the host cell

隐孢子虫影响上皮细胞更新,并且对诱导宿主细胞死亡具有抵抗力。

Wallbank, Bethan A; Pardy, Ryan D; Brodsky, Igor E; Hunter, Christopher A; Striepen, Boris

Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape Without Side Effects

脂质纳米颗粒相关炎症由内体损伤感知触发:构建无副作用的内体逃逸机制

Omo-Lamai, Serena; Wang, Yufei; Patel, Manthan N; Essien, Eno-Obong; Shen, Mengwen; Majumdar, Aparajeeta; Espy, Carolann; Wu, Jichuan; Channer, Breana; Tobin, Michael; Murali, Shruthi; Papp, Tyler E; Maheshwari, Rhea; Wang, Liuqian; Chase, Liam S; Zamora, Marco E; Arral, Mariah L; Marcos-Contreras, Oscar A; Myerson, Jacob W; Hunter, Christopher A; Tsourkas, Andrew; Muzykantov, Vladimir; Brodsky, Igor; Shin, Sunny; Whitehead, Kathryn A; Gaskill, Peter; Discher, Dennis; Parhiz, Hamideh; Brenner, Jacob S