日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Scalable, compressed phenotypic screening using pooled perturbations

利用合并扰动进行可扩展、压缩的表型筛选

Nuo Liu # ,Walaa E Kattan # ,Benjamin E Mead # ,Conner Kummerlowe # ,Thomas Cheng ,Sarah Ingabire ,Jaime H Cheah ,Christian K Soule ,Anita Vrcic ,Jane K McIninch ,Sergio Triana ,Manuel Guzman ,Tyler T Dao ,Joshua M Peters ,Kristen E Lowder ,Lorin Crawford ,Ava P Amini ,Paul C Blainey ,William C Hahn ,Brian Cleary ,Bryan Bryson ,Peter S Winter ,Srivatsan Raghavan ,Alex K Shalek

Maternal HIV infection drives altered placental Mtb-specific antibody transfer

母体艾滋病毒感染导致胎盘结核分枝杆菌特异性抗体转移改变

Nadege Nziza, Wonyeong Jung, Maanasa Mendu, Tina Chen, Ryan P McNamara, Sarah M Fortune, Kees L M C Franken, Tom H M Ottenhoff, Bryan Bryson, Joseph Ngonzi, Lisa M Bebell, Galit Alter

Contrastive learning in protein language space predicts interactions between drugs and protein targets

蛋白质语言空间中的对比学习可预测药物与蛋白质靶标之间的相互作用

Rohit Singh, Samuel Sledzieski, Bryan Bryson, Lenore Cowen, Bonnie Berger

Compressed phenotypic screens for complex multicellular models and high-content assays

针对复杂多细胞模型和高内涵分析的压缩表型筛选

Benjamin E Mead, Conner Kummerlowe, Nuo Liu, Walaa E Kattan, Thomas Cheng, Jaime H Cheah, Christian K Soule, Josh Peters, Kristen E Lowder, Paul C Blainey, William C Hahn, Brian Cleary, Bryan Bryson, Peter S Winter, Srivatsan Raghavan, Alex K Shalek

Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control

对猕猴肺部肉芽肿进行多模态分析揭示了结核病控制的细胞学相关性

Hannah P Gideon ,Travis K Hughes ,Constantine N Tzouanas ,Marc H Wadsworth 2nd ,Ang Andy Tu ,Todd M Gierahn ,Joshua M Peters ,Forrest F Hopkins ,Jun-Rong Wei ,Conner Kummerlowe ,Nicole L Grant ,Kievershen Nargan ,Jia Yao Phuah ,H Jacob Borish ,Pauline Maiello ,Alexander G White ,Caylin G Winchell ,Sarah K Nyquist ,Sharie Keanne C Ganchua ,Amy Myers ,Kush V Patel ,Cassaundra L Ameel ,Catherine T Cochran ,Samira Ibrahim ,Jaime A Tomko ,Lonnie James Frye ,Jacob M Rosenberg ,Angela Shih ,Michael Chao ,Edwin Klein ,Charles A Scanga ,Jose Ordovas-Montanes ,Bonnie Berger ,Joshua T Mattila ,Rajhmun Madansein ,J Christopher Love ,Philana Ling Lin ,Alasdair Leslie ,Samuel M Behar ,Bryan Bryson ,JoAnne L Flynn ,Sarah M Fortune ,Alex K Shalek

Artificial neural networks enable genome-scale simulations of intracellular signaling

人工神经网络实现基因组规模的细胞内信号模拟

Avlant Nilsson #, Joshua M Peters #, Nikolaos Meimetis, Bryan Bryson, Douglas A Lauffenburger

JAK inhibition in a patient with a STAT1 gain-of-function variant reveals STAT1 dysregulation as a common feature of aplastic anemia

在携带 STAT1 功能获得性变异的患者中进行 JAK 抑制,揭示了 STAT1 失调是再生障碍性贫血的常见特征。

Jacob M Rosenberg ,Joshua M Peters ,Travis Hughes ,Caleb A Lareau ,Leif S Ludwig ,Lucas R Massoth ,Christina Austin-Tse ,Heidi L Rehm ,Bryan Bryson ,Yi-Bin Chen ,Aviv Regev ,Alex K Shalek ,Sarah M Fortune ,David B Sykes

MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas

MEK 抑制可增强突变黑色素瘤中可靶向 MHC-I 肿瘤抗原的呈递

Lauren E Stopfer, Nicholas J Rettko, Owen Leddy, Joshua M Mesfin, Eric Brown, Shannon Winski, Bryan Bryson, James A Wells, Forest M White

The cellular architecture of the antimicrobial response network in human leprosy granulomas

人类麻风肉芽肿抗菌反应网络的细胞结构

Feiyang Ma, Travis K Hughes, Rosane M B Teles, Priscila R Andrade, Bruno J de Andrade Silva, Olesya Plazyo, Lam C Tsoi, Tran Do, Marc H Wadsworth 2nd, Aislyn Oulee, Maria Teresa Ochoa, Euzenir N Sarno, M Luisa Iruela-Arispe, Eynav Klechevsky, Bryan Bryson, Alex K Shalek, Barry R Bloom, Johann E Gudj

Efficient integration of heterogeneous single-cell transcriptomes using Scanorama

使用 Scanorama 高效整合异质单细胞转录组

Brian Hie, Bryan Bryson, Bonnie Berger