Inhibition of mTORC1/C2 signaling improves anti-leukemia efficacy of JAK/STAT blockade in CRLF2 rearranged and/or JAK driven Philadelphia chromosome-like acute B-cell lymphoblastic leukemia
抑制 mTORC1/C2 信号通路可提高 JAK/STAT 阻断疗法在 CRLF2 重排和/或 JAK 驱动的费城染色体样急性 B 细胞淋巴母细胞白血病中的抗白血病疗效。
期刊:Oncotarget
影响因子:
doi:10.18632/oncotarget.24261
Zhang, Qi; Shi, Ce; Han, Lina; Jain, Nitin; Roberts, Kathryn G; Ma, Helen; Cai, Tianyu; Cavazos, Antonio; Tabe, Yoko; Jacamo, Rodrigo O; Mu, Hong; Zhao, Yang; Wang, Jing; Wu, Shuo-Chieh; Cao, Fenglin; Zeng, Zhihong; Zhou, Jin; Mi, Yingchang; Jabbour, Elias J; Levine, Ross; Tasian, Sarah K; Mullighan, Charles G; Weinstock, David M; Fruman, David A; Konopleva, Marina
CRLF2
JAK/STAT
ORC1
T细胞
白血病
信号转导
mTOR
细胞生物学