日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Nanomechanical binding mechanism of ligands drives agonistic activity.

配体的纳米机械结合机制驱动激动活性

Seferovic Hannah, Sticht Patricia, Hain Lisa, Zhu Rong, Diethör Sebastian, Wechselberger Christian, Weber Florian, Bernhard David, Plochberger Birgit, Oh Yoo Jin, Chaparro-Riggers Javier, Hinterdorfer Peter

Structural elucidation of the haptoglobin-hemoglobin clearance mechanism by macrophage scavenger receptor CD163

巨噬细胞清道夫受体CD163介导的结合珠蛋白-血红蛋白清除机制的结构阐明

Huang, Ching-Shin; Wang, Hui; White, Joshua B R; Degtjarik, Oksana; Huynh, Cindy; Brannstrom, Kristoffer; Horn, Mark T; Muench, Stephen P; Somers, William S; Chaparro-Riggers, Javier; Lin, Laura; Mosyak, Lidia

Pharmacokinetics, pharmacodynamics, and toxicity of a PD-1-targeted IL-15 in cynomolgus monkeys

PD-1 靶向 IL-15 在食蟹猴中的药代动力学、药效学和毒性

Changhua Ji, Bing Kuang, Bernard S Buetow, Allison Vitsky, Yuanming Xu, Tzu-Hsuan Huang, Javier Chaparro-Riggers, Eugenia Kraynov, Diane Matsumoto

Direct control of CAR T cells through small molecule-regulated antibodies

通过小分子调节抗体直接控制 CAR-T 细胞

Spencer Park #, Edward Pascua #, Kevin C Lindquist #, Christopher Kimberlin, Xiaodi Deng, Yvonne S L Mak, Zea Melton, Theodore O Johnson, Regina Lin, Bijan Boldajipour, Robert T Abraham, Jaume Pons, Barbra Johnson Sasu, Thomas J Van Blarcom, Javier Chaparro-Riggers

Dual checkpoint blockade of CD47 and PD-L1 using an affinity-tuned bispecific antibody maximizes antitumor immunity

利用亲和力优化的双特异性抗体对CD47和PD-L1进行双重检查点阻断,可最大限度地发挥抗肿瘤免疫力。

Chen, Shih-Hsun; Dominik, Pawel K; Stanfield, Jessica; Ding, Sheng; Yang, Wenjing; Kurd, Nadia; Llewellyn, Ryan; Heyen, Jonathan; Wang, Carole; Melton, Zea; Van Blarcom, Thomas; Lindquist, Kevin C; Chaparro-Riggers, Javier; Salek-Ardakani, Shahram

One size does not fit all: navigating the multi-dimensional space to optimize T-cell engaging protein therapeutics

一刀切的做法并不适用所有情况:探索多维空间以优化 T 细胞接合蛋白疗法

Wei Chen, Fan Yang, Carole Wang, Jatin Narula, Edward Pascua, Irene Ni, Sheng Ding, Xiaodi Deng, Matthew Ling-Hon Chu, Amber Pham, Xiaoyue Jiang, Kevin C Lindquist, Patrick J Doonan, Tom Van Blarcom, Yik Andy Yeung, Javier Chaparro-Riggers

Structural delineation and phase-dependent activation of the costimulatory CD27:CD70 complex

共刺激CD27:CD70复合物的结构界定和相位依赖性激活

Weifeng Liu ,Zachary Maben ,Carole Wang ,Kevin C Lindquist ,Manqing Li ,Vinayak Rayannavar ,Ilsel Lopez Armenta ,Andrew Nager ,Edward Pascua ,Pawel K Dominik ,David Oyen ,Hui Wang ,Rachel Carson Roach ,Corey M Allan ,Lidia Mosyak ,Javier Chaparro-Riggers

An Optimized Full-Length FLT3/CD3 Bispecific Antibody Demonstrates Potent Anti-leukemia Activity and Reversible Hematological Toxicity

优化的全长 FLT3/CD3 双特异性抗体表现出强效的抗白血病活性和可逆的血液学毒性

Yik Andy Yeung, Veena Krishnamoorthy, Danielle Dettling, Cesar Sommer, Kris Poulsen, Irene Ni, Amber Pham, Wei Chen, Sindy Liao-Chan, Kevin Lindquist, S Michael Chin, Allison Given Chunyk, Wenyue Hu, Barbra Sasu, Javier Chaparro-Riggers, Ivana Djuretic

Allogeneic FLT3 CAR T Cells with an Off-Switch Exhibit Potent Activity against AML and Can Be Depleted to Expedite Bone Marrow Recovery

具有关闭开关的同种异体 FLT3 CAR-T 细胞表现出对抗 AML 的强效活性,并且可以消耗以加快骨髓恢复

Cesar Sommer, Hsin-Yuan Cheng, Duy Nguyen, Danielle Dettling, Yik Andy Yeung, Janette Sutton, Moustafa Hamze, Julien Valton, Julianne Smith, Ivana Djuretic, Javier Chaparro-Riggers, Barbra J Sasu

CD40 agonist-induced IL-12p40 potentiates hepatotoxicity

CD40激动剂诱导的IL-12p40增强肝毒性

Bonnans, Caroline; Thomas, Graham; He, Wenqian; Jung, Breanna; Chen, Wei; Liao, Min; Heyen, Jonathan; Buetow, Bernard; Pillai, Smitha; Matsumoto, Diane; Chaparro-Riggers, Javier; Salek-Ardakani, Shahram; Qu, Yan