日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

METTL3 mediates m(6)A methylation of ADAM17 to Downregulate ACE2-Ang-(1-7) axis and promote progression of hypertension

METTL3介导ADAM17的m(6)A甲基化，从而下调ACE2-Ang-(1-7)轴并促进高血压的进展

期刊:Journal of Advanced Research
影响因子:13
doi:10.1016/j.jare.2025.08.026
Fei, Xuejie; Li, Caiyu; Bai, Jie; Xu, Yu; Hu, Ruihua; Wang, Xingxing; Pan, Yan; Zhu, Xinrui; Chen, Kequan; Chen, Aidong; Zhang, Lei; Han, Ying
MET
心血管
ADA
表观遗传
高血压
ACE2
ADAM17
发表日期：2026
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Efficient production of glycine from glucose via a two-stage biosynthetic strategy

通过两阶段生物合成策略高效地利用葡萄糖生产甘氨酸

期刊:Microbial Cell Factories
影响因子:4.9
doi:10.1186/s12934-026-02966-3
Chen, Lei; Zheng, Zhijie; Chen, Feifei; Wang, Weipeng; Huo, Siqi; Li, Xiangyu; Zhang, Alei; Chen, Kequan
发表日期：2026
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Integrative analysis and functional validation identified palmitoylated PHGDH as a therapeutic target for colon adenocarcinoma

整合分析和功能验证确定棕榈酰化PHGDH是结肠腺癌的治疗靶点。

期刊:Cellular Oncology
影响因子:4.8
doi:10.1007/s13402-026-01207-4
Song, Yixian; Lin, Lingling; Liu, Dejian; Zhu, Mengqing; Wang, Pei; Li, Ke; Li, Aimin; Chen, Kequan; Ye, Zhanhui
肿瘤
肿瘤免疫
PHGDH
发表日期：2026
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De novo biosynthesis of putrescine from glucose using engineered Escherichia coli in a two-step process

利用基因工程改造的大肠杆菌，通过两步法从葡萄糖中从头合成腐胺。

期刊:Synthetic and Systems Biotechnology
影响因子:4.4
doi:10.1016/j.synbio.2026.02.008
Yin, Lang; Li, Hongxu; Du, Min; Liu, Zhangyu; Wang, Jing; Xu, Sheng; Wang, Xin; Chen, Kequan
发表日期：2026
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De novo biosynthesis of 1,5-diamino-2-hydroxypentane from glucose via combination of fermentation and whole-cell catalysis

利用发酵和全细胞催化相结合的方法，从葡萄糖中从头合成1,5-二氨基-2-羟基戊烷

期刊:Synthetic and Systems Biotechnology
影响因子:4.4
doi:10.1016/j.synbio.2026.01.036
Zheng, Zhijie; Chen, Zhongliang; Tang, Tongqing; Lu, Haoyu; Xu, Qian; Yang, Zixun; Liu, Wei; Wu, Chaoqiang; Hu, Shewei; Chen, Feifei; Zhang, Alei; Chen, Kequan
细胞生物学
发表日期：2026
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UHRF2 related to sumoylation : assessment of its role in immune suppression and therapeutic potential in colorectal cancer

UHRF2 与 SUMO 化相关：评估其在免疫抑制中的作用及其在结直肠癌治疗中的潜力

期刊:BMC Cancer
影响因子:3.4
doi:10.1186/s12885-026-15727-7
Huang, Mei; Qin, Yan; Yang, Qiong; Chen, Xueqing; Chen, Kequan
肿瘤
肠癌
肿瘤免疫
SUMO
免疫/内分泌
发表日期：2026
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Unveiling the genetic overlap and causal links between gastroesophageal reflux disease and asthma

揭示胃食管反流病与哮喘之间的基因重叠和因果关系

期刊:International Journal of Surgery
影响因子:10.1
doi:10.1097/JS9.0000000000003283
Zhang, Yajie; Li, Yang; Huang, Wentao; Tong, Shuangshuang; Zeng, Ruijie; Lyu, Yanlin; Leung, Felix W; Chen, Kequan; Sha, Weihong; Chen, Hao
胃食管反流病
哮喘
发表日期：2025
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A Chitosan-Binding Protein Mediated the Affinity Immobilization of Enzymes on Various Polysaccharide Microspheres

壳聚糖结合蛋白介导酶在各种多糖微球上的亲和固定

期刊:Foods
影响因子:5.1
doi:10.3390/foods14111981
Zhao, Dexin; Peng, Shiguo; Chen, Feifei; Zhang, Alei; Chen, Kequan
发表日期：2025
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Advances in clinical applications of microneedle

微针临床应用进展

期刊:Frontiers in Pharmacology
影响因子:4.8
doi:10.3389/fphar.2025.1607210
Chen, Kequan; Sun, Xinyu; Liu, Yangkaiyuan; Li, Shiyu; Meng, Dianhuai
发表日期：2025
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Enzyme and cofactor engineering to increase d-xylonate dehydratase activity for improved d-1,2,4-butanetriol production from d-xylose

通过酶和辅因子工程提高D-木糖酸脱水酶活性，从而提高D-木糖制备D-1,2,4-丁三醇的效率

期刊:Synthetic and Systems Biotechnology
影响因子:4.4
doi:10.1016/j.synbio.2025.07.003
Chen, Jingwen; Liu, Zhangyu; Mai, Dandan; Xu, Sheng; Wang, Xin; Chen, Kequan
发表日期：2025
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