日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Single-Cell and Spatial Transcriptomics Identified Fatty Acid-Binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension

单细胞和空间转录组学鉴定出控制肺动脉高压中内皮糖酵解和动脉编程的脂肪酸结合蛋白

Bin Liu ,Dan Yi ,Shuai Li ,Karina Ramirez ,Xiaomei Xia ,Yanhong Cao ,Hanqiu Zhao ,Ankit Tripathi ,Shenfeng Qiu ,Mrinalini Kala ,Ruslan Rafikov ,Haiwei Gu ,Vinicio de Jesus Perez ,Sarah-Eve Lemay ,Christopher C Glembotski ,Kenneth S Knox ,Sebastien Bonnet ,Vladimir V Kalinichenko ,You-Yang Zhao ,Michael B Fallon ,Olivier Boucherat ,Zhiyu Dai

ATF6 protects against protein misfolding during cardiac hypertrophy

ATF6 可防止心脏肥大过程中蛋白质错误折叠

Christoph Hofmann, Marjan Aghajani, Cecily D Alcock, Erik A Blackwood, Clara Sandmann, Nicole Herzog, Julia Groß, Lars Plate, R Luke Wiseman, Randal J Kaufman, Hugo A Katus, Tobias Jakobi, Mirko Völkers, Christopher C Glembotski, Shirin Doroudgar

Single-cell and Spatial Transcriptomics Identified Fatty Acid-binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension

单细胞和空间转录组学鉴定出控制肺动脉高压内皮糖酵解和动脉编程的脂肪酸结合蛋白

Bin Liu, Dan Yi, Shuai Li, Karina Ramirez, Xiaomei Xia, Yanhong Cao, Hanqiu Zhao, Ankit Tripathi, Shenfeng Qiu, Mrinalini Kala, Ruslan Rafikov, Haiwei Gu, Vinicio de Jesus Perez, Sarah-Eve Lemay, Christopher C Glembotski, Kenneth S Knox, Sebastien Bonnet, Vladimir V Kalinichenko, You-Yang Zhao, Mich

mTORC1 inhibition impairs activation of the unfolded protein response and induces cell death during ER stress in cardiomyocytes

mTORC1 抑制会损害未折叠蛋白反应的激活,并在内质网应激期间诱导心肌细胞死亡

Christoph Hofmann, Zoe Löwenthal, Marjan Aghajani, Randal J Kaufman, Hugo A Katus, Norbert Frey, Christopher C Glembotski, Mirko Völkers, Shirin Doroudgar

Optimization of Large-Scale Adeno-Associated Virus (AAV) Production

大规模腺相关病毒 (AAV) 生产的优化

Alina S Bilal, Sarah N Parker, Victoria B Murray, Lauren F MacDonnell, Donna J Thuerauf, Christopher C Glembotski, Erik A Blackwood

The peroxisomal enzyme, FAR1, is induced during ER stress in an ATF6-dependent manner in cardiac myocytes

在心肌细胞中,过氧化物酶体酶FAR1在内质网应激期间以ATF6依赖的方式被诱导。

Kayleigh G Marsh ,Adrian Arrieta ,Donna J Thuerauf ,Erik A Blackwood ,Lauren MacDonnell ,Christopher C Glembotski

Proteomic analysis of the cardiac myocyte secretome reveals extracellular protective functions for the ER stress response

心肌细胞分泌组的蛋白质组学分析揭示了内质网应激反应的细胞外保护功能

Erik A Blackwood, Donna J Thuerauf, Miroslava Stastna, Haley Stephens, Zoe Sand, Amber Pentoney, Khalid Azizi, Tobias Jakobi, Jennifer E Van Eyk, Hugo A Katus, Christopher C Glembotski, Shirin Doroudgar

Mesencephalic astrocyte-derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart

中脑星形胶质细胞衍生的神经营养因子是一种内质网驻留分子伴侣,可保护心脏免受还原应激

Adrian Arrieta, Erik A Blackwood, Winston T Stauffer, Michelle Santo Domingo, Alina S Bilal, Donna J Thuerauf, Amber N Pentoney, Cathrine Aivati, Anup V Sarakki, Shirin Doroudgar, Christopher C Glembotski

The ER Unfolded Protein Response Effector, ATF6, Reduces Cardiac Fibrosis and Decreases Activation of Cardiac Fibroblasts

ER 未折叠蛋白反应效应物 ATF6 可减少心脏纤维化并降低心脏成纤维细胞的活化

Winston T Stauffer, Erik A Blackwood, Khalid Azizi, Randal J Kaufman, Christopher C Glembotski

Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis

药理学 ATF6 激活通过重编程细胞蛋白稳态为广泛疾病模型提供全球保护

Erik A Blackwood, Khalid Azizi, Donna J Thuerauf, Ryan J Paxman, Lars Plate, Jeffery W Kelly, R Luke Wiseman, Christopher C Glembotski