日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural basis for transthiolation intermediates in the ubiquitin pathway

泛素途径中转硫代中间体的结构基础

Tomasz Kochańczyk, Zachary S Hann, Michaelyn C Lux, Avelyn Mae V Delos Reyes, Cheng Ji, Derek S Tan, Christopher D Lima

Structural basis for a nucleoporin exportin complex between RanBP2, SUMO1-RanGAP1, the E2 Ubc9, Crm1 and the Ran GTPase

RanBP2、SUMO1-RanGAP1、E2 Ubc9、Crm1 和 Ran GTPase 之间的核孔蛋白输出蛋白复合物的结构基础

Vladimir Baytshtok, Michael A DiMattia, Christopher D Lima

Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex

人类核外泌体靶向(NEXT)复合物对RNA进行监视的结构基础

M Rhyan Puno,Christopher D Lima

YTHDC2 control of gametogenesis requires helicase activity but not m6A binding

YTHDC2 控制配子发生需要解旋酶活性但不需要 m6A 结合

Yuhki Saito, Ben R Hawley #, M Rhyan Puno #, Shreya N Sarathy, Christopher D Lima, Samie R Jaffrey, Robert B Darnell, Scott Keeney, Devanshi Jain

Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions

分枝杆菌硫辛酰胺脱氢酶的全细胞活性抑制剂通过紧密结合相互作用对人类酶具有选择性

John Ginn, Xiuju Jiang, Shan Sun, Mayako Michino, David J Huggins, Zodwa Mbambo, Robert Jansen, Kyu Y Rhee, Nancy Arango, Christopher D Lima, Nigel Liverton, Toshihiro Imaeda, Rei Okamoto, Takanobu Kuroita, Kazuyoshi Aso, Andrew Stamford, Michael Foley, Peter T Meinke, Carl Nathan, Ruslana Bryk

Substrate discrimination and quality control require each catalytic activity of TRAMP and the nuclear RNA exosome

底物鉴别和质量控制需要TRAMP和核RNA外泌体各自的催化活性

Mom Das, Dimitrios Zattas, John C Zinder, Elizabeth V Wasmuth, Julien Henri, Christopher D Lima

Reconstitution of S. cerevisiae RNA Exosome Complexes Using Recombinantly Expressed Proteins

使用重组表达的蛋白质重建酿酒酵母 RNA 外泌体复合物

John C Zinder, Christopher D Lima

ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2

ketu 突变小鼠揭示了古老的 RNA 解旋酶 YTHDC2 的重要减数分裂功能

Devanshi Jain, M Rhyan Puno, Cem Meydan, Nathalie Lailler, Christopher E Mason, Christopher D Lima, Kathryn V Anderson, Scott Keeney

Discovery and engineering of enhanced SUMO protease enzymes

增强型 SUMO 蛋白酶的发现和设计

Yue-Ting K Lau, Vladimir Baytshtok, Tessa A Howard, Brooke M Fiala, JayLee M Johnson, Lauren P Carter, David Baker, Christopher D Lima, Christopher D Bahl

Nuclear RNA Exosome at 3.1 Å Reveals Substrate Specificities, RNA Paths, and Allosteric Inhibition of Rrp44/Dis3

3.1 Å 的核 RNA 外泌体揭示底物特异性、RNA 路径和 Rrp44/Dis3 的变构抑制

John C Zinder, Elizabeth V Wasmuth, Christopher D Lima