日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A comprehensive atlas of AAV tropism in the mouse

小鼠体内AAV嗜性的综合图谱

Christopher J Walkey ,Kathy J Snow ,Jote Bulcha ,Aaron R Cox ,Alexa E Martinez ,M Cecilia Ljungberg ,Denise G Lanza ,Marco De Giorgi ,Marcel A Chuecos ,Michele Alves-Bezerra ,Carlos Flores Suarez ,Sean M Hartig ,Susan G Hilsenbeck ,Chih-Wei Hsu ,Ethan Saville ,Yaned Gaitan ,Jeff Duryea Jr ,Seth Hannigan ,Mary E Dickinson ,Oleg Mirochnitchenko ,Dan Wang ,Cathleen M Lutz ,Jason D Heaney ,Guangping Gao ,Stephen A Murray ,William R Lagor

Targeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier

通过设计能够穿过血脑屏障的衣壳受体相互作用,将 AAV 载体靶向中枢神经系统

Qin Huang, Albert T Chen, Ken Y Chan, Hikari Sorensen, Andrew J Barry, Bahar Azari, Qingxia Zheng, Thomas Beddow, Binhui Zhao, Isabelle G Tobey, Cynthia Moncada-Reid, Fatma-Elzahraa Eid, Christopher J Walkey, M Cecilia Ljungberg, William R Lagor, Jason D Heaney, Yujia A Chan, Benjamin E Deverman

In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene

通过暂时抑制必需基因实现基因靶向肝细胞的体内扩增

Marco De Giorgi, So Hyun Park, Adam Castoreno, Mingming Cao, Ayrea Hurley, Lavanya Saxena, Marcel A Chuecos, Christopher J Walkey, Alexandria M Doerfler, Mia N Furgurson, M Cecilia Ljungberg, Kalyani R Patel, Sarah Hyde, Tyler Chickering, Stephanie Lefebvre, Kelly Wassarman, Patrick Miller, June Qin

AAV5 delivery of CRISPR-Cas9 supports effective genome editing in mouse lung airway

AAV5递送CRISPR-Cas9可有效编辑小鼠肺部气道中的基因组。

Shun-Qing Liang ,Christopher J Walkey ,Alexa E Martinez ,Qin Su ,Mary E Dickinson ,Dan Wang ,William R Lagor ,Jason D Heaney ,Guangping Gao ,Wen Xue

MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass

MAF1 是 RNA 聚合酶 III 依赖性转录的抑制剂,可调节骨量

Ellen Phillips, Naseer Ahmad, Li Sun, James Iben, Christopher J Walkey, Aleksandra Rusin, Tony Yuen, Clifford J Rosen, Ian M Willis, Mone Zaidi, Deborah L Johnson

Susceptibility of Rat Steatotic Liver to Ischemia-Reperfusion Is Treatable With Liver-Selective Matrix Metalloproteinase Inhibition

大鼠脂肪肝对缺血再灌注的敏感性可通过肝脏选择性基质金属蛋白酶抑制剂治疗

Xiangdong Wang, Christopher J Walkey, Ana C Maretti-Mira, Lei Wang, Deborah L Johnson, Laurie D DeLeve

The RNA polymerase III repressor MAF1 is regulated by ubiquitin-dependent proteasome degradation and modulates cancer drug resistance and apoptosis

RNA 聚合酶 III 阻遏物 MAF1 受泛素依赖性蛋白酶体降解调控,并调节癌症耐药性和细胞凋亡

Xianlong Wang, Aleksandra Rusin, Christopher J Walkey, Justin J Lin, Deborah L Johnson

Maf1 and Repression of RNA Polymerase III-Mediated Transcription Drive Adipocyte Differentiation

Maf1和RNA聚合酶III介导的转录抑制促进脂肪细胞分化

Chun-Yuan Chen, Rainer B Lanz, Christopher J Walkey, Wen-Hsuan Chang, Wange Lu, Deborah L Johnson