日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A community-led initiative to de-risk and advance Parkinson's disease therapeutic targets

一项由社区主导的倡议,旨在降低帕金森病治疗靶点的风险并推进其发展

Vaiana, Alexandra; Behr, Jonathan; Birol, Ryan; Blauwendraat, Cornelis; Casey, Bradford; Chowdhury, Kushan; Citron, Martin; Crapser, Joshua; Dardov, Victoria; Ducotterd, Fiona; Dumanis, Sonya; Dunlop, John; Durborow, Michelle; Fiske, Brian; Golden, Jessica; Hannestad, Jonas; Hung, Wendy; Kemp, Jennifer; Kleiman, Robin; Knight, Adam; Koemeter-Cox, Andrew; Leuchter, Bruce; Logsdon, Bejamin A; Marreiros, Rita; Miller, Julie E; Mitchell, Amanda; Mukherjee, Pooja; Navarro, Grace; Nelson, Matthew R; Nikolich, Karoly; Otis, Tom; Polinski, Nicole; Rastegar-Pouyani, Shima; Reith, Alastair D; Riley, Ekemini; Rubin, Lee; Ryten, Mina; Sadick, Jessica; Schwabe, Tina; Sherer, Todd; Silvergleid, Sarah; Singleton, Andrew; St Clair, Lara; Stoehr, Jan; Stone, David J; Sullivan, Julianna; Tanenbaum, Nicole; Tinelli, Elisa; Trimble, Kate; Wang, Yifei; Weninger, Stacie; Wiggenhauser, Nicolás; Wood, Stephen; Schoepp, Darryle; Buggia-Prevot, Virginie; Padmanabhan, Shalini; Skibinski, Gaia

Differential role of C-terminal truncations on alpha-synuclein pathology and Lewy body formation.

端截短对 α-突触核蛋白病理和路易体形成的影响差异

Mahul-Mellier Anne-Laure, Altay Melek Firat, Maharjan Niran, Ait-Bouziad Nadine, Chiki Anass, Jagannath Somanath, Limorenko Galina, Novello Salvatore, Ricci Jonathan, Jasiqi Yllza, Vingill Siv, Wade-Martins Richard, Holton Janice, Strand Catherine, Haikal Caroline, Li Jia-Yi, Hamelin Romain, Croisier Marie, Knott Graham, Mairet-Coello Georges, Weerens Laura, Michel Anne, Downey Patrick, Citron Martin, Lashuel Hilal A

Reply to Matters Arising: In vivo effects of the alpha-synuclein misfolding inhibitor minzasolmin supports clinical development in Parkinson's disease

针对相关问题的答复:α-突触核蛋白错误折叠抑制剂minzasolmin的体内效应支持其在帕金森病中的临床开发

Price, Diana L; Khan, Asma; Angers, Rachel; Cardenas, Alvaro; Prato, Maria Key; Bani, Massimo; Bonhaus, Douglas W; Citron, Martin; Biere, Anja-Leona

Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression

在两种转基因模型中,使用抗Tau抗体进行被动免疫可减少Tau病理并延缓疾病进展。

Chai, Xiyun; Wu, Su; Murray, Tracey K; Kinley, Robert; Cella, Claire V; Sims, Helen; Buckner, Nicola; Hanmer, Jenna; Davies, Peter; O'Neill, Michael J; Hutton, Michael L; Citron, Martin

beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins

β-分泌酶的切割并非生成淀粉样前体蛋白家族胞内C端结构域所必需。

Sala Frigerio, Carlo; Fadeeva, Julia V; Minogue, Aedín M; Citron, Martin; Van Leuven, Fred; Staufenbiel, Matthias; Paganetti, Paolo; Selkoe, Dennis J; Walsh, Dominic M

Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity

β位点APP裂解酶1(BACE1)参与淀粉样前体蛋白介导的记忆增强和活动依赖性突触可塑性

Ma, Huifang; Lesné, Sylvain; Kotilinek, Linda; Steidl-Nichols, Jill V; Sherman, Mathew; Younkin, Linda; Younkin, Steven; Forster, Colleen; Sergeant, Nicolas; Delacourte, André; Vassar, Robert; Citron, Martin; Kofuji, Paulo; Boland, Linda M; Ashe, Karen H

BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice.

BACE1 基因缺失可防止 5XFAD APP/PS1 转基因小鼠出现神经元丢失和记忆缺陷

Ohno Masuo, Cole Sarah L, Yasvoina Marina, Zhao Jie, Citron Martin, Berry Robert, Disterhoft John F, Vassar Robert

Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis.

淀粉样斑块周围神经元中β位点淀粉样前体蛋白裂解酶1水平升高:对阿尔茨海默病发病机制的影响

Zhao Jie, Fu Yifan, Yasvoina Marina, Shao Peizhen, Hitt Brian, O'Connor Tracy, Logan Sreemathi, Maus Erika, Citron Martin, Berry Robert, Binder Lester, Vassar Robert