日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dorsal root ganglion toxicity after AAV intra-CSF delivery of a RNAi expression construct into non-human primates and mice.

将 RNAi 表达构建体通过 AAV 脑脊液内递送至非人灵长类动物和小鼠后,引起背根神经节毒性

Hawley Zachary C E, Pardo Ingrid D, Cao Shaolong, Zavodszky Maria I, Casey Fergal, Ferber Kyle, Luo Yi, Hana Sam, Chen Shukkwan K, Doherty Jessica, Costa Raquel, Cullen Patrick, Liu Yuqing, Carlile Thomas M, Chowdhury Twinkle, Doyle Benjamin, Clarner Pete, Mangaudis Kevin, Guilmette Edward, Bourque Shawn, Koske David, Nadella Murali V P, Trapa Patrick, Hawes Michael L, Raitcheva Denitza, Lo Shih-Ching

Genomic ncRNAs regulating mitochondrial function in neurodegeneration: a neglected clue in the complex etiopathogenesis of multiple sclerosis

基因组非编码RNA调控神经退行性疾病中的线粒体功能:多发性硬化症复杂病因学中一个被忽视的线索

Sanadgol, Nima; Samadi, Mahedeh; Voelz, Clara; Khalseh, Roghayeh; Amini, Javad; Beyer, Cordian; Kipp, Markus; Clarner, Tim

CREB regulates Foxp3(+)ST-2(+) T(REGS) with enhanced IL-10 production

CREB通过增强IL-10的产生来调节Foxp3(+)ST-2(+) T(REGS)的产生。

Hebbar Subramanyam, Sudheendra; Turyne Hriczko, Judit; Schulz, Saskia; Look, Thomas; Goodarzi, Tannaz; Clarner, Tim; Scheld, Miriam; Kipp, Markus; Verjans, Eva; Böll, Svenja; Neullens, Christopher; Costa, Ivan; Li, Zhijian; Gan, Lin; Denecke, Bernd; Schippers, Angela; Floess, Stefan; Huehn, Jochen; Schmitt, Edgar; Bopp, Tobias; Wasmuth, Hermann; Winograd, Ron; Beyaert, Rudi; Lambrecht, Bart; Zenke, Martin; Wagner, Norbert; Ohl, Kim; Tenbrock, Klaus

Engineered microRNA scaffolds for potent gene silencing in vivo.

工程化microRNA支架用于体内强效基因沉默

Militello Giuseppe, Greig Alyssa, Bi Chongfeng, Vasileva Ana, Zavodszky Maria I, Lo Shih-Ching, Guilmette Edward, Clarner Pete, Liu Bin, Bhat Guruharsha, Suh Junghae, Dow Lukas, Zuber Johannes, Fellmann Christof, Premsrirut Prem K

Inhibition of immune response reduces pathology in dorsal root ganglia and peripheral nerves in cynomolgus macaques following AAV gene therapy

抑制免疫反应可减轻食蟹猴在接受腺相关病毒(AAV)基因治疗后背根神经节和周围神经的病理变化。

Grubor, Branka; Henry, Kate L; Chan, Su Jing; Sheehan, Mark; Shah, Anumeha; Pellerin, Alex; Bai, Judy; Nadella, Prasad; Bommegowda, Santhosh; Cullen, Patrick; Tien, Eric; Chen, Vivian; van der Munnik, Nicholas P; White-Hunt, Stephanie; Plowey, Edward D; Hamann, Stefan; Guise, Amanda J; Xu, Shanqin; Kirkland, Melissa; Doherty, Jessica; Lyashenko, Eugenia; Bhat, Guruharsha; Glajch, Kelly; Lo, Shih-Ching; Gianni, Davide; Clarner, Pete; Gagnon, Jake; Chu, Jenhwa; Nambiar, Kalyani; Lulla, Mukesh; Zheng, Fengmei; Weldeab, Asmerom; Bartlett, Dan; Gutnick, Amos; Reynolds, Taylor; Zhu, Kan; Huh, Dann; Carlile, Thomas M; Fikes, James; Trapa, Patrick; Suh, Junghae; Morris, Dale; Burkly, Linda

Efficacy and safety of a SOD1-targeting artificial miRNA delivered by AAV9 in mice are impacted by miRNA scaffold selection

通过 AAV9 在小鼠中递送的针对 SOD1 的人工 miRNA 的有效性和安全性受到 miRNA 支架选择的影响

Shukkwan K Chen, Zachary C E Hawley, Maria I Zavodszky, Sam Hana, Daniel Ferretti, Branka Grubor, Michael Hawes, Shanqin Xu, Stefan Hamann, Galina Marsh, Patrick Cullen, Ravi Challa, Thomas M Carlile, Hang Zhang, Wan-Hung Lee, Andrea Peralta, Pete Clarner, Cong Wei, Kathryn Koszka, Feng Gao, Shih-Ch

Lipocalin-2 Deficiency Diminishes Canonical NLRP3 Inflammasome Formation and IL-1β Production in the Subacute Phase of Spinal Cord Injury

脂质运载蛋白-2 缺乏会减少脊髓损伤亚急性期典型 NLRP3 炎症小体的形成和 IL-1β 的产生

Nina Müller, Miriam Scheld, Clara Voelz, Natalie Gasterich, Weiyi Zhao, Victoria Behrens, Ralf Weiskirchen, Maryam Baazm, Tim Clarner, Cordian Beyer, Nima Sanadgol, Adib Zendedel

Are live lectures a discontinued model? A survey on the influence of synchronous online lecturing on the perception of teaching and assessment outcome

现场授课模式是否已过时?一项关于同步在线授课对教学和评估结果认知影响的调查

Osten, Jannik; Behrens, Victoria; Behrens, Sadie; Herrler, Andreas; Clarner, Tim

Astrocytic Nrf2 expression protects spinal cord from oxidative stress following spinal cord injury in a male mouse model

在雄性小鼠模型中,星形胶质细胞 Nrf2 表达可保护脊髓免受脊髓损伤后的氧化应激

Weiyi Zhao #, Natalie Gasterich #, Tim Clarner, Clara Voelz, Victoria Behrens, Cordian Beyer, Athanassios Fragoulis #, Adib Zendedel #

Development and Application of a Liquid Chromatography-Mass Spectrometry Method for Residual Iodixanol Quantification in AAV-Based Gene Therapy Product Development

开发和应用液相色谱-质谱法定量分析AAV基因治疗产品开发中的残留碘克沙醇

Pu, Yi; Katz, Russell; Chen, Yunqiu; Kostrubsky, Vic; Clarner, Pete; Lo, Shih-Ching; Sosic, Zoran; Yeung, Bernice