日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Overexpression of TNFα in TNF∆ARE+/- mice increases hepatic periportal inflammation and alters bile acid signaling in mice

TNF∆ARE+/- 小鼠中 TNFα 的过度表达会增加小鼠肝脏门管周围炎症并改变胆汁酸信号

Colin T Shearn, Aimee L Anderson, Michael W Devereaux, Samuel D Koch, Leigha D Larsen, Lisa A Spencer, David J Orlicky, Sean P Colgan, Calen A Steiner, Ronald J Sokol

Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition

在同时遭受肠道损伤和肠外营养的小鼠中,细胞因子产生增加导致昼夜节律调节基因的表达失调

Colin T Shearn, Aimee L Anderson, Michael W Devereaux, Karim C El Kasmi, David J Orlicky, Ronald J Sokol

The autophagic protein p62 is a target of reactive aldehydes in human and murine cholestatic liver disease

自噬蛋白 p62 是人类和鼠胆汁淤积性肝病中活性醛的靶点

Colin T Shearn, Aimee L Anderson, Michael W Devereux, David J Orlicky, Cole Michel, Dennis R Petersen, Colin G Miller, Sanjiv Harpavat, Edward E Schmidt, Ronald J Sokol

Bile acids modulate colonic MAdCAM-1 expression in a murine model of combined cholestasis and colitis

胆汁酸调节胆汁淤积和结肠炎小鼠模型中结肠 MAdCAM-1 的表达

Rachel Y Gao, Colin T Shearn, David J Orlicky, Kayla D Battista, Erica E Alexeev, Ian M Cartwright, Jordi M Lanis, Rachael E Kostelecky, Cynthia Ju, Sean P Colgan, Blair P Fennimore

Identification of Dose-Dependent DNA Damage and Repair Responses From Subchronic Exposure to 1,4-Dioxane in Mice Using a Systems Analysis Approach

使用系统分析方法鉴定小鼠亚慢性暴露于 1,4-二氧六环引起的剂量依赖性 DNA 损伤和修复反应

Georgia Charkoftaki, Jaya Prakash Golla, Alvaro Santos-Neto, David J Orlicky, Rolando Garcia-Milian, Ying Chen, Nicholas J W Rattray, Yuping Cai, Yewei Wang, Colin T Shearn, Varvara Mironova, Yensheng Wang, Caroline H Johnson, David C Thompson, Vasilis Vasiliou

Supplemental Ascorbate Diminishes DNA Damage Yet Depletes Glutathione and Increases Acute Liver Failure in a Mouse Model of Hepatic Antioxidant System Disruption

在肝脏抗氧化系统紊乱的小鼠模型中,补充抗坏血酸可减少 DNA 损伤,但会消耗谷胱甘肽并增加急性肝衰竭

Colin G Miller, Jean A Kundert, Justin R Prigge, Julie A Amato, Allison E Perez, Lucia Coppo, Gabrielle N Rizzo, Michael P Kavanaugh, David J Orlicky, Colin T Shearn, Edward E Schmidt

Cholestatic liver disease results increased production of reactive aldehydes and an atypical periportal hepatic antioxidant response

胆汁淤积性肝病导致活性醛生成增加以及门脉周围肝脏抗氧化反应异常

Colin T Shearn, Blair Fennimore, David J Orlicky, Yue R Gao, Laura M Saba, Kayla D Battista, Stefanos Aivazidis, Mohammed Assiri, Peter S Harris, Cole Michel, Gary F Merrill, Edward E Schmidt, Sean P Colgan, Dennis R Petersen

Quantifying Competition among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism

量化乙醇代谢引起的线粒体蛋白质酰化事件之间的竞争

Hadi R Ali, Mohammed A Assiri, Peter S Harris, Cole R Michel, Youngho Yun, John O Marentette, Frank K Huynh, David J Orlicky, Colin T Shearn, Laura M Saba, Richard Reisdorph, Nichole Reisdorph, Matthew D Hirschey, Kristofer S Fritz

Taurine treatment prevents derangement of the hepatic γ-glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria: regulatory crosstalk between thiol and sulfinic acid metabolism

牛磺酸治疗可防止经典同型胱氨酸尿症小鼠模型中肝脏 γ-谷氨酰循环和甲基乙二醛代谢紊乱:硫醇和亚磺酸代谢之间的调节串扰

Kenneth N Maclean, Hua Jiang, Stefanos Aivazidis, Eugene Kim, Colin T Shearn, Peter S Harris, Dennis R Petersen, Robert H Allen, Sally P Stabler, James R Roede

Knockout of the Gsta4 Gene in Male Mice Leads to an Altered Pattern of Hepatic Protein Carbonylation and Enhanced Inflammation Following Chronic Consumption of an Ethanol Diet

雄性小鼠中 Gsta4 基因敲除导致肝脏蛋白质羰基化模式改变,并在长期食用乙醇饮食后导致炎症增强

Colin T Shearn, Casey F Pulliam, Kim Pedersen, Kyle Meredith, Kelly E Mercer, Laura M Saba, David J Orlicky, Martin J Ronis, Dennis R Petersen