日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural insights into VRC01-class bnAb precursors with diverse light chains elicited in the IAVI G001 human vaccine trial

在IAVI G001人体疫苗试验中诱导产生的具有不同轻链的VRC01类广谱中和抗体前体的结构解析

Lin, Xiaohe; Cottrell, Christopher A; Kalyuzhniy, Oleksandr; Tingle, Ryan; Kubitz, Michael; Lu, Danny; Yuan, Meng; Schief, William R; Wilson, Ian A

mRNA delivery of circumsporozoite protein epitope-based malaria vaccines induces protection in a mouse model

利用mRNA递送基于环子孢子蛋白表位的疟疾疫苗可在小鼠模型中诱导保护作用

Wu, Nelson R; Beutler, Nathan; Hu, Xiaozhen; Skog, Patrick D; Liguori, Alessia; Flores-Garcia, Yevel; Maiorino, Laura; Terada, Sierra; Lu, Danny; Lai, Yen-Chung; Ndihokubwayo, Justin; Schiffner, Torben; Cottrell, Christopher A; Eskandarzadeh, Saman; Alavi, Nushin; Kubitz, Michael; Phelps, Nicole; Tingle, Ryan; Hodges, Sam; Youhanna, John E; Amirzehni, Sonya; Irvine, Darrell J; Himansu, Sunny; Zavala, Fidel; Rogers, Thomas F; Burton, Dennis R; Schief, William R

Structural insights into VRC01-class bnAb precursors with diverse light chains elicited in the IAVI G001 human vaccine trial

在IAVI G001人体疫苗试验中诱导产生的具有不同轻链的VRC01类广谱中和抗体前体的结构解析

Lin, Xiaohe; Cottrell, Christopher A; Kalyuzhniy, Oleksandr; Tingle, Ryan; Kubitz, Michael; Lu, Danny; Yuan, Meng; Schief, William R; Wilson, Ian A

Antigen avidity drives the durability of the vaccine immune response

抗原亲和力决定了疫苗免疫反应的持久性

Weidner, Nicole G; Padilla, Mauricio V; Pruitt, Layne; Cottrell, Christopher A; Gonzales, Kristyn; Kalyuzhniy, Oleksandr; Kubitz, Michael; Alavi, Nushin; Phelps, Nicole; Weglarz, Meredith; Schief, William R; Abbott, Robert K

Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial

在一项 I 期临床试验中,接种 mRNA 编码的膜锚定 HIV 包膜三聚体疫苗可诱导产生 2 级中和抗体。

Parks, K Rachael; Moodie, Zoe; Allen, Mary A; Yen, Catherine; Furch, Briana D; MacPhee, Kellie J; Ozorowski, Gabriel; Heptinstall, Jack; Hahn, William O; Zheng, Zihan; Lu, Huiyin; Grant, Shannon; Domin, Elize; Duff, Michael O; Seese, Aaron; Marini-Macouzet, Constanza; Ballweber-Fleming, Lamar; Lee, Wen-Hsin; Cottrell, Christopher A; Liguori, Alessia; Georgeson, Erik; Alavi, Nushin; Kubitz, Michael; Phelps, Nicole; Seaton, Kelly E; Cohen, Kristen W; Anderson, Maija A; Mondal, Kajari; Laufer, Dagna S; Kublin, James G; Ward, Andrew B; Hyrien, Ollivier; De Rosa, Stephen C; Himansu, Sunny; Leav, Brett; Reuter, Caroline; Tomaras, Georgia D; Montefiori, David; Walsh, Stephen R; Frank, Ian; Sobieszczyk, Magdalena E; Goepfert, Paul A; Stephenson, Kathryn E; Baden, Lindsey R; Van Tieu, Hong; Keefer, Michael C; Clark, Jesse; Riddler, Sharon A; Schief, William R; McElrath, M Juliana

Simultaneous priming of HIV broadly neutralizing antibody precursors to multiple epitopes by germline-targeting mRNA-LNP immunogens in mouse models

在小鼠模型中,通过靶向种系的mRNA-LNP免疫原同时启动针对多个表位的广谱HIV中和抗体前体

Xie, Zhenfei; Wang, Xuesong; Yan, Yu; Steichen, Jon M; Ma, Krystal M; Cottrell, Christopher A; Melzi, Eleonora; Bottermann, Maria; Villavicencio, Paula Maldonado; Rantalainen, Kimmo; Schiffner, Torben; Warner, John E; Weldon, Stephanie R; Prum, Thavaleak; Ellis-Pugh, Jordan R; Torres, Jonathan L; Jackson, Abigail M; Flynn, Claudia T; Ozorowski, Gabriel; Himansu, Sunny; Carfi, Andrea; Ward, Andrew B; Nair, Usha; Schief, William R; Batista, Facundo D

Antibody feedback establishes an affinity brake in the germinal center.

抗体反馈在生发中心建立亲和力抑制机制。

Yan Yu, Wang Xuesong, Xie Zhenfei, Bader Daniel L V, Lim Ryan H, Ma Krystal M, Cottrell Christopher A, Steichen Jon M, Xu Liling, Villavicencio Paula Maldonado, Akauliya Madhav, Koo Ja-Hyun, Shen Jacqueline Ming, Vernich Alexandra, Kalyuzhniy Oleksandr, Allen Joel D, Albowaidey Ali A, Alicea Anthony, Chen Bingxian, Georgeson Erik, Ellis-Pugh Jordan Renae, Alavi Nushin, Esposito Abigail, Naili Hannah, Phelps Nicole, Kelley Brendon, Kubitz Michael, Phan Quynh Anh, Liguori Alessia, Prum Thavaleak, Tingle Ryan, Lu Danny, Eskandarzadeh Saman, Liu Xiaotie, Warner John E, Weldon Stephanie R, Himansu Sunny, Crispin Max, Nair Usha, Liu Sophia, Schief William R, Batista Facundo D

Vaccination with mRNA-encoded membrane-bound HIV Envelope trimer induces neutralizing antibodies in animal models.

用 mRNA 编码的膜结合 HIV 包膜三聚体进行疫苗接种,可在动物模型中诱导中和抗体

Ramezani-Rad Parham, Cottrell Christopher A, Marina-Zárate Ester, Liguori Alessia, Landais Elise, Torres Jonathan L, Myers Amber, Lee Jeong Hyun, Baboo Sabyasachi, Flynn Claudia, McKenney Katherine, Salcedo Eugenia, Zhou Xiaoya, Kalyuzhniy Oleksandr, Georgeson Erik, Phelps Nicole, Lu Danny, Eskandarzadeh Saman, Menis Sergey, Kubitz Michael, Groschel Bettina, Alavi Nushin, Jackson Abigail M, Lee Wen-Hsin, Tran Andy S, Ben-Akiva Elana, Michaels Katarzyna Kaczmarek, Diedrich Jolene K, Enemuo Chiamaka A, Lewis Vanessa, Pradhan Arpan, Kasturi Sudhir Pai, Schiffner Torben, Steichen Jon M, Carnathan Diane G, Himansu Sunny, Yates John R 3rd, Paulson James C, Ozorowski Gabriel, Irvine Darrell J, Silvestri Guido, Sok Devin, Ward Andrew B, Crotty Shane, Schief William R

DNA origami vaccines program antigen-focused germinal centers.

DNA折纸疫苗可对抗原靶向的生发中心进行编程

Romanov Anna, Knappe Grant A, Ronsard Larance, Suh Heikyung, Omer Marjan, Chapman Asheley P, Lewis Vanessa R, Spivakovsky Katie, Canales Josue, Reizis Boris, Tingle Ryan D, Cottrell Christopher A, Schiffner Torben, Lingwood Daniel, Bathe Mark, Irvine Darrell J

Author Correction: Vaccination induces broadly neutralizing antibody precursors to HIV gp41

作者更正:接种疫苗可诱导产生针对 HIV gp41 的广谱中和抗体前体

Schiffner, Torben; Phung, Ivy; Ray, Rashmi; Irimia, Adriana; Tian, Ming; Swanson, Olivia; Lee, Jeong Hyun; Lee, Chang-Chun D; Marina-Zárate, Ester; Cho, So Yeon; Huang, Jiachen; Ozorowski, Gabriel; Skog, Patrick D; Serra, Andreia M; Rantalainen, Kimmo; Allen, Joel D; Baboo, Sabyasachi; Rodriguez, Oscar L; Himansu, Sunny; Zhou, Jianfu; Hurtado, Jonathan; Flynn, Claudia T; McKenney, Katherine; Havenar-Daughton, Colin; Saha, Swati; Shields, Kaitlyn; Schultze, Steven; Smith, Melissa L; Liang, Chi-Hui; Toy, Laura; Pecetta, Simone; Lin, Ying-Cing; Willis, Jordan R; Sesterhenn, Fabian; Kulp, Daniel W; Hu, Xiaozhen; Cottrell, Christopher A; Zhou, Xiaoya; Ruiz, Jennifer; Wang, Xuesong; Nair, Usha; Kirsch, Kathrin H; Cheng, Hwei-Ling; Davis, Jillian; Kalyuzhniy, Oleksandr; Liguori, Alessia; Diedrich, Jolene K; Ngo, Julia T; Lewis, Vanessa; Phelps, Nicole; Tingle, Ryan D; Spencer, Skye; Georgeson, Erik; Adachi, Yumiko; Kubitz, Michael; Eskandarzadeh, Saman; Elsliger, Marc A; Amara, Rama R; Landais, Elise; Briney, Bryan; Burton, Dennis R; Carnathan, Diane G; Silvestri, Guido; Watson, Corey T; Yates, John R 3rd; Paulson, James C; Crispin, Max; Grigoryan, Gevorg; Ward, Andrew B; Sok, Devin; Alt, Frederick W; Wilson, Ian A; Batista, Facundo D; Crotty, Shane; Schief, William R