日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Glycoengineering HIV-1 Env creates 'supercharged' and 'hybrid' glycans to increase neutralizing antibody potency, breadth and saturation.

对 HIV-1 Env 进行糖基工程改造,可产生“超强”和“混合”聚糖,以增强中和抗体的效力、广度和饱和度

Crooks Ema T, Grimley Samantha L, Cully Michelle, Osawa Keiko, Dekkers Gillian, Saunders Kevin, Rämisch Sebastian, Menis Sergey, Schief William R, Doria-Rose Nicole, Haynes Barton, Murrell Ben, Cale Evan Mitchel, Pegu Amarendra, Mascola John R, Vidarsson Gestur, Binley James M

Effects of partially dismantling the CD4 binding site glycan fence of HIV-1 Envelope glycoprotein trimers on neutralizing antibody induction.

部分拆除 HIV-1 包膜糖蛋白三聚体的 CD4 结合位点聚糖栅对中和抗体诱导的影响

Crooks Ema T, Osawa Keiko, Tong Tommy, Grimley Samantha L, Dai Yang D, Whalen Robert G, Kulp Daniel W, Menis Sergey, Schief William R, Binley James M

Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site.

疫苗诱导的 2 级 HIV-1 中和抗体与 CD4 结合位点附近缺乏聚糖的四级表位结合

Crooks Ema T, Tong Tommy, Chakrabarti Bimal, Narayan Kristin, Georgiev Ivelin S, Menis Sergey, Huang Xiaoxing, Kulp Daniel, Osawa Keiko, Muranaka Janelle, Stewart-Jones Guillaume, Destefano Joanne, O'Dell Sijy, LaBranche Celia, Robinson James E, Montefiori David C, McKee Krisha, Du Sean X, Doria-Rose Nicole, Kwong Peter D, Mascola John R, Zhu Ping, Schief William R, Wyatt Richard T, Whalen Robert G, Binley James M

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

针对V1V2的强效HIV中和抗体的发育途径

Doria-Rose, Nicole A; Schramm, Chaim A; Gorman, Jason; Moore, Penny L; Bhiman, Jinal N; DeKosky, Brandon J; Ernandes, Michael J; Georgiev, Ivelin S; Kim, Helen J; Pancera, Marie; Staupe, Ryan P; Altae-Tran, Han R; Bailer, Robert T; Crooks, Ema T; Cupo, Albert; Druz, Aliaksandr; Garrett, Nigel J; Hoi, Kam H; Kong, Rui; Louder, Mark K; Longo, Nancy S; McKee, Krisha; Nonyane, Molati; O'Dell, Sijy; Roark, Ryan S; Rudicell, Rebecca S; Schmidt, Stephen D; Sheward, Daniel J; Soto, Cinque; Wibmer, Constantinos Kurt; Yang, Yongping; Zhang, Zhenhai; Mullikin, James C; Binley, James M; Sanders, Rogier W; Wilson, Ian A; Moore, John P; Ward, Andrew B; Georgiou, George; Williamson, Carolyn; Abdool Karim, Salim S; Morris, Lynn; Kwong, Peter D; Shapiro, Lawrence; Mascola, John R

Multi-Parameter Exploration of HIV-1 Virus-Like Particles as Neutralizing Antibody Immunogens in Guinea Pigs, Rabbits and Macaques.

在豚鼠、兔子和猕猴中对 HIV-1 病毒样颗粒作为中和抗体免疫原进行多参数探索

Tong Tommy, Crooks Ema T, Osawa Keiko, Robinson James E, Barnes Mary, Apetrei Cristian, Binley James M

HIV-Specific CD8+ T-cell Expansion Potential, but Not Cytotoxic Capacity, Is Associated with Reduced Set Point Viral Loads in Ad5/HIV Vaccinees

HIV特异性CD8+ T细胞扩增潜能(而非细胞毒性能力)与Ad5/HIV疫苗接种者体内病毒载量设定点降低相关

Hofer, Cristina B; Harris, D Robert; de Oliveira, Ricardo Hugo; de Abreu, Thalita F; Kakehasi, Fabiana; Pilotto, Jose Henrique; Ruz, Noris Pavia; Krauss, Margot R; Hazra, Rohan; Ericsen, Adam; Starrett, Gabriel; Greene, Justin; Lauck, Michael; Mohns, Mariel; Cain, Brian; Pham, Ngoc; Raveendran, Muthuswamy; Deiros, David Rio; Weinfurter, Jason; Bailey, Adam; Karl, Julie; Wiseman, Roger; Muzny, Donna; Friedrich, Thomas; Gibbs, Richard; Rogers, Jeffrey; O'Connor, David H; Courtney, Colleen; Mayr, Luzia; Nogueira, Lilian; Ngai, Johnson; Seaman, Michael; Klein, Florian; Nussenzweig, Michel; Nyambi, Phillipe; Zolla-Pazner, Susan; Duerr, Ralf; Soni, Sonal; Courtney, Colleen; Meli, Josephine; Ngai, Johnson; Mayr, Luzia; Nyambi, Phillipe; Ulrich, Michael; Cheng, Cheng; Georgiev, Ivelin; Joyce, M Gordon; Chen, Xuejun; Bossert, Adam; Kong, Wing-Pui; Kwong, Peter D; Mascola, John R; Archer, Eva J; Bashford-Rogers, Rachael; Hill, Brenna; Douek, Daniel C; Kellam, Paul; Koup, Richard A; Arakelyan, Anush; King, Debbie; Grivel, Jean-Charled; Shattock, Robin J; Margolis, Leonid; Cicala, Claudia; Jelicic, Katija; Cimbro, Raffaello; Nawaz, Fatima; Zheng, Xin; Yang, Jun; Lempicki, Richard; Van Ryk, Donald; Ray, Jocelyn; Hiatt, Joseph; Schwing, Catherine; Wei, Danlan; Pascuccio, Massimiliano; Kehrl, John; Arthos, James; Fauci, Anthony S; Nawaz, Fatima; Cicala, Claudia; Jelicic, Katija; Cimbro, Raffaello; Van Ryk, Donald; Ray, Jocelyn; Hiatt, Joseph; Schwing, Catherine; Wei, Danlan; Pascuccio, Massimiliano; Ansari, Aftab A; Fauci, Anthony S; Arthos, James; Acharya, Priyamvada; Zhou, Tongqing; Soto, Cinque; Chen, Lei; Luongo, Timothy S; Moquin, Stephanie; Georgiev, Ivelin S; Schmidt, Stephen D; Louder, Mark K; Joyce, M Gordon; Yang, Yongping; Zhang, Baoshan; Scheid, Johannes; Nussenzweig, Michel C; Mascola, John R; Kwong, Peter D; Mason, Rosemarie; Adams, Cameron; Bewley, Carole; Mascola, John; Roederer, Mario; Allen, Mary A; Metch, Barbara; Moodie, Zoe; Bekker, Linda-Gail; Churchyard, Gavin; Mlisana, Koleka; Nchabeleng, Maphoshane; Kublin, Jim; Gray, Glenda; Francica, Joseph; Sheng, Zizhang; Nishimura, Yoshiaki; Zhang, Zhenghai; Singh, Manmohan; O'Hagan, Derek T; Douek, Daniel; Kepler, Thomas; Martin, Malcolm; Shapiro, Lawrence; Seder, Robert; Vaccari, Monica; Gordon, Shari N; Fourati, Slim; Schifanella, Luca; Cameron, Mark; Keele, Brandon F; Shen, Xiaoying; Tomaras, Georgia; Billings, Erik; Rao, Mangala; Liyanage, Namal PM; Vargas-Inchaustegui, Diego A; Whitney, Steve; Doster, Melvin N; Binello, Nicolo; Pegu, Poonam; Montefiori, David C; Foulds, Kathryn; Quinn, David S; Donaldson, Mitzi; Liang, Frank; Lore, Karin; Roederer, Mario; Koup, Richard; McDermott, Adrian; Ma, Zhong-Min; Christopher, Miller; Phan, Tran B; Forthal, Donald N; Blackburn, Matthew; Caccuri, Francesca; Ferrari, Guido; Robert-Guroff, Marjorie; Ratto-Kim, Silvia; Kim, Jerome; Michael, Nelson; Phogat, Sanjay; Barnett, Susan W; Tartaglia, James; Venzon, David; Stablein, Donald M; Sekaly, Rafick-Pierre; Franchini, Genoveffa; Lynch, Rebecca M; Yamamoto, Takuya; Wong, Patrick; Georgiev, Ivelin; Matus-Nicodemos, Rodrigo; Schmidt, Stephen; Gautam, Rajeev; Sheng, Zizhang; Shapiro, Lawrence; Nishimura, Yoshiaki; Martin, Malcolm A; Mascola, John R; Koup, Richard A; Doria-Rose, Nicole A; Roark, Ryan S; Moore, Penny; Ernandes, Michael J; Bhiman, Jinal N; Schramm, Chaim A; McKee, Krisha; O'Dell, Sijy; Louder, Mark; Karim, Salim S Abdool; Shapiro, Lawrence; Morris, Lynn; Mascola, John R; Lagenaur, Laurel; Lee, Peter; Parks, Thomas; Schifanella, Luca; Binello, Nicolo; Vaccari, Monica; Gordon, Shari N; Caccuri, Francesca; Blackburn, Matthew; Doster, Melvin; Liynage, Namal; Pegu, Poonam; Shen, Xiaoying; Tomaras, Georgia D; Venzon, David; Stablien, Don; Barnett, Susan W; Barouch, Dan; Phogat, Sanjay; Franchini, Genoveffa; Druz, Alex; Pancera, Marie; Acharya, Priyamvada; Zhou, Tongqing; Joyce, Gordon; Ofek, Adi; Kwong, Peter D; Pancera, Marie; Druz, Aliaksandr; Zhou, Tongqing; O'Dell, Sijy; Louder, Mark; Madani, Navid; Herschhorn, Alon; Sodroski, Joseph; Mascola, John R; Kwong, Peter D; Schiller, John T; Chackerian, Bryce; Georgiev, Ivelin; Joyce, M Gordon; Yang, Yongping; Pancera, Marie; Gorman, Jason; Acharya, Priyamvada; Stewart-Jones, Guillaume; Druz, Aliaksandr; Cheng, Cheng; Mascola, John R; Kwong, Peter D; Liyanage, Namal PM; Doster, Melvin N; Caccuri, Francesca; Pegu, Poonam; Gordon, Shari N; Parks, Robyn Washington; Pise-Masison, Cynthia; Barcena, Luis; Scheider, Jeff; Lakouga, Howard Y; Kiser, Patrick; Whitney, Stephen; Schifanella, Luca; Vaccari, Monica; Hope, Thomas J; Franchini, Genoveffa; Kwon, Young Do; Georgiev, Ivelin S; Zhang, Baoshan; McKee, Krisha; O'Dell, Sijy; Druz, Alex; Shi, Wei; Connors, Mark; Mascola, John R; Kwong, Peter D; Soto, Cinque S; Ofek, Gilad; Joyce, M Gordon; Zhang, Baoshan; McKee, Krisha; Mascola, John R; Kwong, Peter D; Pavlakis, George N; Li, Jinyao; Valentin, Antonio; Jalah, Rashmi; Patel, Vainav; Rosati, Margherita; Kulkarni, Viraj; Alicea, Candido; Vargas-Inchaustegui, Diego A; Guan, Yongjun; Venzon, David; Sardesai, Niranjan; Fouts, Timothy R; Pinter, Abraham; Robert-Guroff, Marjorie; Montefiori, David C; Shen, Xiaoying; Tomaras, Georgia D; Felber, Barbara K; Felber, Barbara K; Hu, Xintao; Kulkarni, Viraj; Valentin, Antonio; Rosati, Margherita; Alicea, Candido; Rolland, Morgane; Le Gall, Sylvie; Sardesai, Niranjan Y; Mothe, Beatriz; Brander, Christian; Mullins, James I; Pavlakis, George N; Huang, Jinghe; Kang, Byong; Wheatley, Adam; Narpala, Sandeep; Mcdermott, Adrian; Poole, April; Bailer, Robert; Koup, Richard; Migueles, Stephen; Gurwith, Marc; Connors, Mark; Cale, Evan M; Doria-Rose, Nicole A; Tong, Tommy; Crooks, Ema T; Nguyen, Richard; Ambrozak, David R; Perfetto, Stephen P; Roederer, Mario; Binley, James M; Mascola, John R; Migueles, Stephen A; Frahm, Nicole; Toulmin, Sushila A; Kelly, Elizabeth P; Peterson, Bennett A; Johnson, Sarah A; McElrath, M J; Connors, Mark

M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding

M48U1 CD4 模拟物通过抑制 gp120 的脱落来减弱病毒颗粒的感染性,从而对细胞相关的 HIV-1 产生持续的抑制作用。

Selhorst, Philippe; Grupping, Katrijn; Tong, Tommy; Crooks, Ema T; Martin, Loïc; Vanham, Guido; Binley, James M; Ariën, Kevin K

Topological analysis of HIV-1 glycoproteins expressed in situ on virus surfaces reveals tighter packing but greater conformational flexibility than for soluble gp120

对病毒表面原位表达的 HIV-1 糖蛋白进行拓扑分析表明,其堆积更紧密,但构象灵活性比可溶性 gp120 更大。

Tong, Tommy; Osawa, Keiko; Robinson, James E; Crooks, Ema T; Binley, James M

HIV-1 virus-like particles bearing pure env trimers expose neutralizing epitopes but occlude nonneutralizing epitopes

携带纯env三聚体的HIV-1病毒样颗粒暴露中和表位,但遮蔽非中和表位。

Tong, Tommy; Crooks, Ema T; Osawa, Keiko; Binley, James M