Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signaling
ULK1缺陷和p53恢复的合成致死性通过ROS/NLRP3信号通路直接上调GSDME转录和切割激活,诱导细胞焦亡。
期刊:Journal of Experimental & Clinical Cancer Research
影响因子:11.4
doi:10.1186/s13046-024-03168-8
Wei Chen #,Kai-Bin Yang #,Yuan-Zhe Zhang #,Zai-Shan Lin #,Jin-Wei Chen,Si-Fan Qi,Chen-Fei Wu,Gong-Kan Feng,Da-Jun Yang,Ming Chen,Xiao-Feng Zhu,Xuan Li #
信号转导
细胞生物学
信号转导
GSDME
LRP3
NLRP3
P53
ULK1
焦亡