日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells

突变型 TP53 的功能丧失而非功能获得特性对于多种癌细胞的增殖、存活和转移至关重要

Zilu Wang, Matteo Burigotto, Sabrina Ghetti, François Vaillant, Tao Tan, Bianca D Capaldo, Michelle Palmieri, Yumiko Hirokawa, Lin Tai, Daniel S Simpson, Catherine Chang, Allan Shuai Huang, Elizabeth Lieschke, Sarah T Diepstraten, Deeksha Kaloni, Chris Riffkin, David C S Huang, Connie S N Li Wai Sue

Divergent roles of RIPK3 and MLKL in high-fat diet-induced obesity and MAFLD in mice

RIPK3 和 MLKL 在小鼠高脂饮食诱发的肥胖和 MAFLD 中发挥的不同作用

Hazel Tye, Stephanie A Conos, Tirta M Djajawi, Timothy A Gottschalk, Nasteho Abdoulkader, Isabella Y Kong, Helene L Kammoun, Vinod K Narayana, Tobias Kratina, Mary Speir, Jack Emery, Daniel S Simpson, Cathrine Hall, Angelina J Vince, Sophia Russo, Rhiannan Crawley, Maryam Rashidi, Joanne M Hildebran

Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency

在 X 连锁凋亡抑制剂 (XIAP) 缺乏的情况下,Caspase-8 驱动的凋亡和焦亡串扰导致细胞死亡和 IL-1β 释放

Sebastian A Hughes #, Meng Lin #, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James M Murphy, Kate E Lawlor, Jaclyn S Pear

Candida auris uses metabolic strategies to escape and kill macrophages while avoiding robust activation of the NLRP3 inflammasome response

耳念珠菌利用代谢策略逃避并杀死巨噬细胞,同时避免强烈激活 NLRP3 炎症小体反应

Harshini Weerasinghe, Claudia Simm, Tirta Mario Djajawi, Irma Tedja, Tricia L Lo, Daniel S Simpson, David Shasha, Naama Mizrahi, Françios A B Olivier, Mary Speir, Kate E Lawlor, Ronen Ben-Ami, Ana Traven

A1 is induced by pathogen ligands to limit myeloid cell death and NLRP3 inflammasome activation

A1 由病原体配体诱导,以限制髓系细胞死亡和 NLRP3 炎症小体活化

Mary Speir #, Hazel Tye #, Timothy A Gottschalk #, Daniel S Simpson, Tirta M Djajawi #, Pankaj Deo #, Rebecca L Ambrose, Stephanie A Conos, Jack Emery, Gilu Abraham, Ashlyn Pascoe, Sebastian A Hughes, Ashley Weir, Edwin D Hawkins, Isabella Kong, Marco J Herold, Jaclyn S Pearson, Najoua Lalaoui, Thom

Mind bomb 2 limits inflammatory dermatitis in Sharpin mutant mice independently of cell death

Mind bomb 2 可以独立于细胞死亡限制 Sharpin 突变小鼠的炎症性皮炎

Daniel S Simpson, Holly Anderton, Jumana Yousef, Vineet Vaibhav, Simon A Cobbold, Esther Bandala-Sanchez, Andrew J Kueh, Laura F Dagley, Marco J Herold, John Silke, James E Vince, Rebecca Feltham

Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway

干扰素-γ通过胱天蛋白酶-8和线粒体细胞死亡途径启动巨噬细胞,以进行病原体配体诱导的杀伤

Daniel S Simpson, Jiyi Pang, Ashley Weir, Isabella Y Kong, Melanie Fritsch, Maryam Rashidi, James P Cooney, Kathryn C Davidson, Mary Speir, Tirta M Djajawi, Sebastian Hughes, Liana Mackiewicz, Merle Dayton, Holly Anderton, Marcel Doerflinger, Yexuan Deng, Allan Shuai Huang, Stephanie A Conos, Hazel

Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms

开发 NanoLuc 靶向蛋白质降解剂和通用报告系统,以对标标签靶向降解平台

Christoph Grohmann #, Charlene M Magtoto #, Joel R Walker, Ngee Kiat Chua, Anna Gabrielyan, Mary Hall, Simon A Cobbold, Stephen Mieruszynski, Martin Brzozowski, Daniel S Simpson, Hao Dong, Bridget Dorizzi, Annette V Jacobsen, Emma Morrish, Natasha Silke, James M Murphy, Joan K Heath, Andrea Testa, C

The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation

IL-1β 的泛素化限制了 caspase-1 对其的切割,并将其作为蛋白酶体降解的目标

Swarna L Vijayaraj #, Rebecca Feltham #, Maryam Rashidi, Daniel Frank, Zhengyang Liu, Daniel S Simpson, Gregor Ebert, Angelina Vince, Marco J Herold, Andrew Kueh, Jaclyn S Pearson, Laura F Dagley, James M Murphy, Andrew I Webb, Kate E Lawlor, James E Vince

RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development

RIPK1 在发育过程中阻止 TRADD 驱动但 TNFR1 非依赖性的细胞凋亡。

Holly Anderton ,Esther Bandala-Sanchez ,Daniel S Simpson ,James A Rickard ,Ashley P Ng ,Ladina Di Rago ,Cathrine Hall ,James E Vince ,John Silke ,Gianmaria Liccardi ,Rebecca Feltham