日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features

上皮 TGFβ 参与生长因子信号传导,以规避细胞凋亡并驱动具有侵袭性特征的肠道肿瘤发生

Dustin J Flanagan #, Raheleh Amirkhah #, David F Vincent #, Nuray Gunduz, Pauline Gentaz, Patrizia Cammareri, Aoife J McCooey, Amy M B McCorry, Natalie C Fisher, Hayley L Davis, Rachel A Ridgway, Jeroen Lohuis, Joshua D G Leach, Rene Jackstadt, Kathryn Gilroy, Elisa Mariella, Colin Nixon, William Cl

Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth

ECT2 的异常表达和亚细胞定位驱动结直肠癌的进展和生长

Danielle R Cook, Melissa Kang, Timothy D Martin, Joseph A Galanko, Gabriela H Loeza, Dimitri G Trembath, Verline Justilien, Karen A Pickering, David F Vincent, Armin Jarosch, Philipp Jurmeister, Andrew M Waters, Priya S Hibshman, Andrew D Campbell, Catriona A Ford, Temitope O Keku, Jen Jen Yeh, Mich

Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis

致癌基因 BRAF 不受 TGFβ 受体信号传导的限制,可驱动右侧结肠肿瘤发生

Joshua D G Leach, Nikola Vlahov, Petros Tsantoulis, Rachel A Ridgway, Dustin J Flanagan, Kathryn Gilroy, Nathalie Sphyris, Ester G Vázquez, David F Vincent, William J Faller, Michael C Hodder, Alexander Raven, Sigrid Fey, Arafath K Najumudeen, Douglas Strathdee, Colin Nixon, Mark Hughes, William Cla

Generation of a conditional Flpo/FRT mouse model expressing constitutively active TGFβ in fibroblasts

构建成纤维细胞中组成型表达活性TGFβ的条件性Flpo/FRT小鼠模型

Victoire Cardot-Ruffino ,Véronique Chauvet ,Cassandre Caligaris ,Adrien Bertrand-Chapel ,Nicolas Chuvin ,Roxane M Pommier ,Ulrich Valcourt ,David F Vincent ,Sylvie Martel ,Sophie Aires ,Bastien Kaniewski ,Pierre Dubus ,Philippe Cassier ,Stéphanie Sentis # ,Laurent Bartholin #

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

TGFβ 抑制可通过抑制旁分泌衰老来恢复急性肝损伤中的再生反应

Thomas G Bird, Miryam Müller, Luke Boulter, David F Vincent, Rachel A Ridgway, Elena Lopez-Guadamillas, Wei-Yu Lu, Thomas Jamieson, Olivier Govaere, Andrew D Campbell, Sofía Ferreira-Gonzalez, Alicia M Cole, Trevor Hay, Kenneth J Simpson, William Clark, Ann Hedley, Mairi Clarke, Pauline Gentaz, Coli

Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis

N-WASP 的缺失导致 Apc 肠道肿瘤发生模型的早期进展

Hayley T Morris, Loic Fort, Heather J Spence, Rachana Patel, David F Vincent, James H Park, Scott B Snapper, Francis A Carey, Owen J Sansom, Laura M Machesky

A novel mouse model of testicular granulosa cell tumors

睾丸颗粒细胞肿瘤的新型小鼠模型

Xin Fang, Nan Ni, Yang Gao, David F Vincent, Laurent Bartholin, Qinglei Li

Glandular defects in the mouse uterus with sustained activation of TGF-beta signaling is associated with altered differentiation of endometrial stromal cells and formation of stromal compartment

小鼠子宫腺体缺陷伴有 TGF-β 信号持续激活,与子宫内膜基质细胞分化改变和基质区室形成有关

Nan Ni, Yang Gao, Xin Fang, Maria Melgar, David F Vincent, John P Lydon, Laurent Bartholin, Qinglei Li

Modulating the therapeutic response of tumours to dietary serine and glycine starvation

调节肿瘤对饮食中丝氨酸和甘氨酸饥饿的治疗反应

Oliver D K Maddocks, Dimitris Athineos, Eric C Cheung, Pearl Lee, Tong Zhang, Niels J F van den Broek, Gillian M Mackay, Christiaan F Labuschagne, David Gay, Flore Kruiswijk, Julianna Blagih, David F Vincent, Kirsteen J Campbell, Fatih Ceteci, Owen J Sansom, Karen Blyth, Karen H Vousden

TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis

TGFβ 通路限制 WNT 和 MAPK 通路激活后的去分化,从而抑制肠道肿瘤发生

Patrizia Cammareri, David F Vincent, Michael C Hodder, Rachel A Ridgway, Claudio Murgia, Max Nobis, Andrew D Campbell, Julia Varga, David J Huels, Chithra Subramani, Katie L H Prescott, Colin Nixon, Ann Hedley, Simon T Barry, Florian R Greten, Gareth J Inman, Owen J Sansom