Virus-free CRISPR knockin of a chimeric antigen receptor into KLRC1 generates potent GD2-specific natural killer cells.
利用无病毒 CRISPR 技术将嵌合抗原受体敲入 KLRC1 中,可产生强效的 GD2 特异性自然杀伤细胞
期刊:Molecular Therapy
影响因子:12
doi:10.1016/j.ymthe.2025.01.024
Shankar Keerthana, Zingler-Hoslet Isabelle, Tabima Diana M, Zima Seth, Shi Lei, Gimse Kirstan, Forsberg Matthew H, Katta Varun, Davis Sage Z, Maldonado Daniel, Russell Brittany E, Murtaza Muhammed, Tsai Shengdar Q, Ayuso Jose M, Capitini Christian M, Saha Krishanu