日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Inhibitors of the Cancer Target Ribonucleotide Reductase, Past and Present

癌症靶标核糖核苷酸还原酶抑制剂:过去与现在

Huff, Sarah E; Winter, Jordan M; Dealwis, Chris G

Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis

捕获二氢叶酸还原酶的催化质子:对一般酸碱催化的启示

Wan, Qun; Bennett, Brad C; Wymore, Troy; Li, Zhihong; Wilson, Mark A; Brooks, Charles L 3rd; Langan, Paul; Kovalevsky, Andrey; Dealwis, Chris G

Robust, atlas-free, automatic segmentation of brain MRI in health and disease

稳健、无需图谱、自动分割健康和疾病状态下的脑部MRI图像

Selvaganesan, Kartiga; Whitehead, Emily; DeAlwis, Paba M; Schindler, Matthew K; Inati, Souheil; Saad, Ziad S; Ohayon, Joan E; Cortese, Irene C M; Smith, Bryan; Steven Jacobson; Nath, Avindra; Reich, Daniel S; Inati, Sara; Nair, Govind

Inhibition of yeast ribonucleotide reductase by Sml1 depends on the allosteric state of the enzyme

Sml1对酵母核糖核苷酸还原酶的抑制作用取决于该酶的变构状态。

Misko, Tessianna A; Wijerathna, Sanath R; Radivoyevitch, Tomas; Berdis, Anthony J; Ahmad, Md Faiz; Harris, Michael E; Dealwis, Chris G

Preliminary joint X-ray and neutron protein crystallographic studies of ecDHFR complexed with folate and NADP+

初步联合X射线和中子蛋白质晶体学研究ecDHFR与叶酸和NADP+的复合物

Wan, Qun; Kovalevsky, Andrey Y; Wilson, Mark A; Bennett, Brad C; Langan, Paul; Dealwis, Chris

Evaluating the therapeutic potential of a non-natural nucleotide that inhibits human ribonucleotide reductase

评估抑制人类核苷酸还原酶的非天然核苷酸的治疗潜力

Md Faiz Ahmad, Qun Wan, Shalini Jha, Edward Motea, Anthony Berdis, Chris Dealwis

Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization

核苷酸诱导寡聚化对人核糖核苷酸还原酶变构调节的结构基础

Fairman, James Wesley; Wijerathna, Sanath Ranjan; Ahmad, Md Faiz; Xu, Hai; Nakano, Ryo; Jha, Shalini; Prendergast, Jay; Welin, R Martin; Flodin, Susanne; Roos, Annette; Nordlund, Pär; Li, Zongli; Walz, Thomas; Dealwis, Chris Godfrey

Histidine hydrogen-deuterium exchange mass spectrometry for probing the microenvironment of histidine residues in dihydrofolate reductase

组氨酸氢氘交换质谱法探测二氢叶酸还原酶中组氨酸残基的微环境

Masaru Miyagi, Qun Wan, Md Faiz Ahmad, Giridharan Gokulrangan, Sara E Tomechko, Brad Bennett, Chris Dealwis

Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease

在阿尔茨海默病转基因小鼠模型中,被动免疫的治疗作用与神经炎症作用取决于Aβ/淀粉样蛋白的负荷。

Minami, S Sakura; Sidahmed, Elkhansa; Aid, Saba; Shimoji, Mika; Niikura, Takako; Mocchetti, Italo; Rebeck, G William; Prendergast, Jay S; Dealwis, Chris; Wetzel, Ronald; Bosetti, Francesca; Matsuoka, Yasuji; Hoe, Hyang-Sook; Turner, R Scott

X-ray structure of the ternary MTX.NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor design

炭疽二氢叶酸还原酶三元 MTX.NADPH 复合物的 X 射线结构:用于双位点抑制剂设计的药效团

Brad C Bennett, Qun Wan, Md Faiz Ahmad, Paul Langan, Chris G Dealwis