日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Radiogenomic Profiling of Prostate Tumors prior to External Beam Radiotherapy Converges on a Transcriptomic Signature of TGF-β Activity Driving Tumor Recurrence

前列腺肿瘤在接受外照射放射治疗前的放射基因组学分析表明,TGF-β活性驱动肿瘤复发的转录组特征显著。

Anson T Ku ,Uma Shankavaram ,Shana Y Trostel ,Hong Zhang ,Sumeyra Kartal ,Houssein A Sater ,Stephanie A Harmon ,Nicole V Carrabba ,Yang Liu ,Hyunnam Ryu ,James A Proudfoot ,Boon Hao Hong ,Bradford J Wood ,Peter A Pinto ,Peter L Choyke ,Mack Roach ,Howard M Sandler ,Stephanie L Pugh ,Kenneth L Zeitzer ,Lucas C Mendez ,Nirav S Kapadia ,William A Hall ,Anand B Desai ,Radka S Stoyanova ,Alan Pollack ,Elai Davicioni ,Melvin L K Chua ,Baris Turkbey ,Adam G Sowalsky ,Deborah E Citrin

A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins

一种基于结构设计的小分子能够消耗 hRpn13Pru 和特定 KEN 盒蛋白。

Xiuxiu Lu,Monika Chandravanshi,Venkata R Sabbasani,Snehal Gaikwad,V Keith Hughitt,Nana Gyabaah-Kessie,Bradley T Scroggins,Sudipto Das,Wazo Myint,Michelle E Clapp,Charles D Schwieters,Marzena A Dyba,Derek L Bolhuis,Janusz W Koscielniak,Thorkell Andresson,Michael J Emanuele,Nicholas G Brown,Hiroshi Matsuo,Raj Chari,Deborah E Citrin,Beverly A Mock,Rolf E Swenson,Kylie J Walters

Radiogenomic profiling of prostate tumors prior to external beam radiotherapy converges on a transcriptomic signature of TGF-β activity driving tumor recurrence

外部放射治疗前前列腺肿瘤的放射基因组学分析集中于驱动肿瘤复发的 TGF-β 活性的转录组特征

Anson T Ku, Uma Shankavaram, Shana Y Trostel, Hong Zhang, Houssein A Sater, Stephanie A Harmon, Nicole V Carrabba, Yang Liu, Bradford J Wood, Peter A Pinto, Peter L Choyke, Radka Stoyanova, Elai Davicioni, Alan Pollack, Baris Turkbey, Adam G Sowalsky, Deborah E Citrin

Senescence-associated tumor growth is promoted by 12-Lipoxygenase

12-脂氧合酶促进衰老相关的肿瘤生长

Shilpa Patil, Jessica L Reedy, Bradley T Scroggins, Ayla O White, Seokjoo Kwon, Uma Shankavaram, Alfonso López-Coral, Eun Joo Chung, Deborah E Citrin

Natural variation in macrophage polarization and function impact pneumocyte senescence and susceptibility to fibrosis

巨噬细胞极化和功能的自然变化影响肺细胞衰老和对纤维化的易感性

Eun Joo Chung, Seokjoo Kwon, Uma Shankavaram, Ayla O White, Shaoli Das, Deborah E Citrin

IGF-1 Receptor Signaling Regulates Type II Pneumocyte Senescence and Resulting Macrophage Polarization in Lung Fibrosis

IGF-1受体信号传导调节II型肺泡细胞衰老和由此导致的肺纤维化巨噬细胞极化

Eun Joo Chung ,Seokjoo Kwon ,Jessica L Reedy ,Ayla O White ,Joon Seon Song ,Ilseon Hwang ,Joon Yong Chung ,Kris Ylaya ,Stephen M Hewitt ,Deborah E Citrin

12-Lipoxygenase is a Critical Mediator of Type II Pneumocyte Senescence, Macrophage Polarization and Pulmonary Fibrosis after Irradiation

12-脂氧合酶是 II 型肺细胞衰老、巨噬细胞极化和照射后肺纤维化的关键介质

Eun Joo Chung, Jessica L Reedy, Seokjoo Kwon, Shilpa Patil, Luca Valle, Ayla O White, Deborah E Citrin

PARP-1 inhibition with or without ionizing radiation confers reactive oxygen species-mediated cytotoxicity preferentially to cancer cells with mutant TP53

无论是否使用电离辐射,PARP-1 抑制都会优先对具有突变 TP53 的癌细胞产生活性氧介导的细胞毒性

Qi Liu, Liliana Gheorghiu, Michael Drumm, Rebecca Clayman, Alec Eidelman, Matthew F Wszolek, Aria Olumi, Adam Feldman, Meng Wang, Lynnette Marcar, Deborah E Citrin, Chin-Lee Wu, Cyril H Benes, Jason A Efstathiou, Henning Willers

Long-term Tumor Adaptation after Radiotherapy: Therapeutic Implications for Targeting Integrins in Prostate Cancer

放射治疗后的长期肿瘤适应性:针对前列腺癌整合素的治疗意义

Iris Eke, Adeola Y Makinde, Molykutty J Aryankalayil, Jessica L Reedy, Deborah E Citrin, Sunita Chopra, Mansoor M Ahmed, C Norman Coleman

Targeting loss of the Hippo signaling pathway in NF2-deficient papillary kidney cancers

针对 NF2 缺陷型乳头状肾癌中 Hippo 信号通路的缺失

Carole Sourbier #, Pei-Jyun Liao #, Christopher J Ricketts, Darmood Wei, Youfeng Yang, Sarah M Baranes, Benjamin K Gibbs, Lernik Ohanjanian, L Spencer Krane, Bradley T Scroggins, J Keith Killian, Ming-Hui Wei, Toshiki Kijima, Paul S Meltzer, Deborah E Citrin, Len Neckers, Cathy D Vocke, W Marston Li