日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants

对莱顿长寿研究参与者中发现的编码 MAPK/ERK 信号通路基因的罕见变异进行功能表征

期刊:Geroscience
影响因子:5.4
doi:10.1007/s11357-025-01699-2
Baghdadi, Maarouf; Hinterding, Helena; Gehrmann, Thies; Putter, Pasquale; Neuerburg, Mara; Lakenberg, Nico; van den Akker, Erik B; Slagboom, P Eline; Deelen, Joris; Partridge, Linda
信号转导
MAPK/ERK
发表日期：2026
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The MetaboHealth Score Enhances Insulin Resistance Metabotyping for Targeted Fat Loss: The PERSON Study

MetaboHealth评分增强胰岛素抵抗代谢分型以实现靶向减脂：PERSON研究

期刊:
影响因子:
doi:10.1002/oby.70116
Morwani-Mangnani, Jordi; Bogaards, Fatih A; Umanets, Alexander; Hul, Gabby B; Gijbels, Anouk; Goossens, Gijs H; Deelen, Joris; Beekman, Marian; Afman, Lydia; Blaak, Ellen E; Slagboom, P Eline
代谢
免疫/内分泌
发表日期：2026
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The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan.

抗衰老药物曲美替尼和雷帕霉素协同作用，可延长小鼠的健康寿命和寿命

期刊:Nature Aging
影响因子:19.4
doi:10.1038/s43587-025-00876-4
Gkioni Lisonia, Nespital Tobias, Baghdadi Maarouf, Monzó Carolina, Bali Jitin, Nassr Taim, Cremer Anna Lena, Beyer Andreas, Deelen Joris, Backes Heiko, Grönke Sebastian, Partridge Linda
发育与干细胞
Mouse
发表日期：2025
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Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport

三项队列研究中，极高的 MetaboHealth 评分与血浆炎症和胆固醇转运蛋白标志物相关。

期刊:Immunity & Ageing
影响因子:5.6
doi:10.1186/s12979-025-00527-7
Bizzarri, Daniele; van den Akker, Erik B; Reinders, Marcel J T; Pool, René; Beekman, Marian; Lakenberg, Nico; Drouin, Nicolas; Stecker, Kelly E; Heck, Albert J R; Knol, Edward F; Vergeer, Jeannette M; Ikram, M Arfan; Ghanbari, Mohsen; van Gool, Alain J; Deelen, Joris; Bbmri-Nl; Boomsma, Dorret I; Slagboom, P Eline
炎症/感染
炎症
代谢
发表日期：2025
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German longevity study reveals novel rare pro-longevity alleles clustering in mTOR signaling pathway

德国长寿研究揭示了mTOR信号通路中聚集的新型罕见长寿等位基因。

期刊:Geroscience
影响因子:5.4
doi:10.1007/s11357-025-01640-7
Kolbe, Daniel; Dose, Janina; Putter, Pasquale; Ziemann, Malte; Laudes, Matthias; Slagboom, P Eline; Franke, Andre; Deelen, Joris; Nebel, Almut
信号转导
mTOR
发表日期：2025
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Rare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families

在多代长寿家族中发现了罕见的与长寿相关的变异，包括cGAS基因中的功能降低突变。

期刊:
影响因子:
doi:10.64898/2025.12.04.689698
Putter, Pasquale C; Guan, Di; Gehrmann, Thies; Kolbe, Daniel; Yang, Jiping; Han, HyeRim; Kim, Seungsoo; Lakenberg, Nico; Suchiman, H Eka D; Trompet, Stella; Liu, Georg C; Ballhysa, Eugen; Antebi, Adam; van den Berg, Niels M A; Nebel, Almut; Beekman, Marian; Suh, Yousin; Slagboom, P Eline; Deelen, Joris
发表日期：2025
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A Novel Metabolomic Aging Clock Predicting Health Outcomes and Its Genetic and Modifiable Factors

一种预测健康结果的新型代谢组学衰老时钟及其遗传和可改变因素

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202406670
Jia, Xueqing; Fan, Jiayao; Wu, Xucheng; Cao, Xingqi; Ma, Lina; Abdelrahman, Zeinab; Zhao, Fei; Zhu, Haitao; Bizzarri, Daniele; Akker, Erik B van den; Slagboom, P Eline; Deelen, Joris; Zhou, Dan; Liu, Zuyun
衰老
代谢
发表日期：2024
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NMR metabolomics-guided DNA methylation mortality predictors

核磁共振代谢组学指导的DNA甲基化死亡率预测因子

期刊:EBioMedicine
影响因子:10.8
doi:10.1016/j.ebiom.2024.105279
Bizzarri, Daniele; Reinders, Marcel J T; Kuiper, Lieke; Beekman, Marian; Deelen, Joris; van Meurs, Joyce B J; van Dongen, Jenny; Pool, René; Boomsma, Dorret I; Ghanbari, Mohsen; Franke, Lude; Slagboom, Pieternella E; van den Akker, Erik B
表观遗传
DNA甲基化
代谢
发表日期：2024
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Intermittent rapamycin feeding recapitulates some effects of continuous treatment while maintaining lifespan extension

间歇性雷帕霉素治疗可以重现持续治疗的部分效果，同时延长寿命。

期刊:Molecular Metabolism
影响因子:6.6
doi:10.1016/j.molmet.2024.101902
Baghdadi, Maarouf; Nespital, Tobias; Monzó, Carolina; Deelen, Joris; Grönke, Sebastian; Partridge, Linda
发表日期：2024
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The performance of metabolomics-based prediction scores for mortality in older patients with solid tumors

基于代谢组学的预测评分在老年实体瘤患者死亡率预测中的表现

期刊:Geroscience
影响因子:5.4
doi:10.1007/s11357-024-01261-6
van Holstein, Yara; Mooijaart, Simon P; van Oevelen, Mathijs; van Deudekom, Floor J; Vojinovic, Dina; Bizzarri, Daniele; van den Akker, Erik B; Noordam, Raymond; Deelen, Joris; van Heemst, Diana; de Glas, Nienke A; Holterhues, Cynthia; Labots, Geert; van den Bos, Frederiek; Beekman, Marian; Slagboom, P Eline; van Munster, Barbara C; Portielje, Johanneke E A; Trompet, Stella
代谢
发表日期：2024
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