日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A combined AI and cell biology approach surfaces targets and mechanistically distinct Inflammasome inhibitors

人工智能与细胞生物学相结合的方法揭示了靶点和机制不同的炎症小体抑制剂

Daniel Chen, Tempest Plott, Michael Wiest, Will Van Trump, Ben Komalo, Dat Nguyen, Charlie Marsh, Jarred Heinrich, Colin J Fuller, Lauren Nicolaisen, Elisa Cambronero, An Nguyen, Christian Elabd, Francesco Rubbo, Rachel DeVay Jacobson

Riluzole Administration to Rats with Levodopa-Induced Dyskinesia Leads to Loss of DNA Methylation in Neuronal Genes

利鲁唑对患有左旋多巴诱发的运动障碍的大鼠给药导致神经元基因 DNA 甲基化的丧失

Luca Pagliaroli, Abel Fothi, Ester Nespoli, Istvan Liko, Borbala Veto, Piroska Devay, Flora Szeri, Bastian Hengerer, Csaba Barta, Tamas Aranyi

Human PCSK9 promotes hepatic lipogenesis and atherosclerosis development via apoE- and LDLR-mediated mechanisms.

人类 PCSK9 通过 apoE 和 LDLR 介导的机制促进肝脏脂肪生成和动脉粥样硬化的发展

Tavori Hagai, Giunzioni Ilaria, Predazzi Irene M, Plubell Deanna, Shivinsky Anna, Miles Joshua, Devay Rachel M, Liang Hong, Rashid Shirya, Linton MacRae F, Fazio Sergio

Local effects of human PCSK9 on the atherosclerotic lesion

人PCSK9对动脉粥样硬化病变的局部作用

Giunzioni, Ilaria; Tavori, Hagai; Covarrubias, Roman; Major, Amy S; Ding, Lei; Zhang, Youmin; DeVay, Rachel M; Hong, Liang; Fan, Daping; Predazzi, Irene M; Rashid, Shirya; Linton, MacRae F; Fazio, Sergio

Common Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Epitopes Mediate Multiple Routes for Internalization and Function

常见前蛋白转化酶枯草溶菌素/Kexin 9 型 (PCSK9) 表位介导内化和功能的多种途径

Rachel M DeVay, Lynn Yamamoto, David L Shelton, Hong Liang

Characterization of proprotein convertase subtilisin/kexin type 9 (PCSK9) trafficking reveals a novel lysosomal targeting mechanism via amyloid precursor-like protein 2 (APLP2)

对前蛋白转化酶枯草溶菌素/kexin 9 型 (PCSK9) 运输的表征揭示了一种通过淀粉样蛋白前体样蛋白 2 (APLP2) 的新型溶酶体靶向机制

Rachel M DeVay, David L Shelton, Hong Liang

Body mass index affects proliferation and osteogenic differentiation of human subcutaneous adipose tissue-derived stem cells

体重指数影响人皮下脂肪组织来源干细胞的增殖和成骨分化

Frazier, Trivia P; Gimble, Jeffrey M; Devay, Jessica W; Tucker, Hugh A; Chiu, Ernest S; Rowan, Brian G

Increasing serum half-life and extending cholesterol lowering in vivo by engineering antibody with pH-sensitive binding to PCSK9

通过设计与 PCSK9 具有 pH 敏感结合的抗体来增加血清半衰期并延长体内降低胆固醇的时间

Javier Chaparro-Riggers, Hong Liang, Rachel M DeVay, Lanfang Bai, Janette E Sutton, Wei Chen, Tao Geng, Kevin Lindquist, Meritxell Galindo Casas, Leila M Boustany, Colleen L Brown, Jeffrey Chabot, Bruce Gomes, Pamela Garzone, Andrea Rossi, Pavel Strop, Dave Shelton, Jaume Pons, Arvind Rajpal

A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria

以线粒体为中心的遗传相互作用图揭示了线粒体内膜组织所需的支架状复合物

Suzanne Hoppins, Sean R Collins, Ann Cassidy-Stone, Eric Hummel, Rachel M Devay, Laura L Lackner, Benedikt Westermann, Maya Schuldiner, Jonathan S Weissman, Jodi Nunnari

Target-specific control of nicotinic receptor expression at developing interneuronal synapses in chick

鸡胚发育中神经元突触处尼古丁受体表达的靶向特异性调控

Devay, P; McGehee, D S; Yu, C R; Role, L W