日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A druggable redox switch on SHP1 controls macrophage inflammation

SHP1 上的可药物调控的氧化还原开关控制巨噬细胞炎症

Ng, Mei Ying; Nix, Meredith N; Du, Guangyan; Davidek, Ivan; Burger, Nils; Shin, Sanghee; Toenjes, Sean; Takeda, Haruna; Cheah Xin Yan, Megan; Zhang, Bingsen; Xiao, Haopeng; Wei, Shelley M; Seo, Hyuk-Soo; Dhe-Paganon, Sirano; Wales, Thomas E; Engen, John R; Mills, Evanna L; Che, Jianwei; Zhang, Tinghu; Gray, Nathanael S; Chouchani, Edward T

AI-Enhanced Adaptive Virtual Screening Platform Enabling Exploration of 69 Billion Molecules Discovers Structurally Validated FSP1 Inhibitors

AI增强型自适应虚拟筛选平台可探索690亿个分子,并发现结构验证的FSP1抑制剂

Cecchini, Domiziana; Nigam, AkshatKumar; Tang, Ming; Reis, Joana; Koop, Matt; Gottinger, Andrea; Nicoll, Callum Robert; Wang, Yao; Jayaraj, Abhilash; Çınaroğlu, Süleyman Selim; Törner, Ricarda; Malets, Yehor; Gehev, Minko; Das, Krishna M Padmanabha; Churion, Kelly; Kim, Jongwan; Thomas, Nidhin; Li, Yong; Seo, Hyuk-Soo; Dhe-Paganon, Sirano; Secker, Christopher; Haddadnia, Mohammad; Hasson, Alexander; Li, Minkai; Kumar, Abhishek; Levin-Konigsberg, Roni; Choi, Eun-Bee; Shapiro, Geoffrey I; Cox, Huel; Sebastian, Luke; Braithwaite, Chelsea; Bashyal, Puspalata; Radchenko, Dmytro S; Kumar, Aditya; Yang, Lei; Aquilanti, Pierre-Yves; Gabb, Henry; Alhossary, Amr; Wagner, Gerhard; Aspuru-Guzik, Alán; Moroz, Yurii S; Kalodimos, Charalampos G; Fackeldey, Konstantin; Schuetz, John D; Mattevi, Andrea; Arthanari, Haribabu; Gorgulla, Christoph

The human zinc-binding cysteine proteome.

人类锌结合半胱氨酸蛋白质组

Burger Nils, Mittenbühler Melanie J, Xiao Haopeng, Shin Sanghee, Wei Shelley M, Henze Erik K, Schindler Sebastian, Mehravar Sepideh, Wood David M, Petrocelli Jonathan J, Sun Yizhi, Sprenger Hans-Georg, Latorre-Muro Pedro, Smythers Amanda L, Bozi Luiz H M, Darabedian Narek, Zhu Yingde, Seo Hyuk-Soo, Dhe-Paganon Sirano, Che Jianwei, Chouchani Edward T

Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma.

米诺林-蛋白酶体通路的结构基础及其在抑制骨髓瘤中的作用

Nardone Christopher, Gao Jingjing, Seo Hyuk-Soo, Mintseris Julian, Ort Lucy, Yip Matthew C J, Negasi Milen, Besschetnova Anna K, Kamitaki Nolan, Gygi Steven P, Dhe-Paganon Sirano, Munshi Nikhil C, Fulciniti Mariateresa, Greenberg Michael E, Shao Sichen, Elledge Stephen J, Gu Xin

Structural insights into chemoresistance mutants of BCL-2 and their targeting by stapled BAD BH3 helices.

BCL-2 化学耐药突变体的结构见解及其被 BAD BH3 螺旋钉合物靶向的作用。

DeAngelo Thomas M, Adhikary Utsarga, Korshavn Kyle J, Seo Hyuk-Soo, Brotzen-Smith Clara R, Camara Christina M, Dhe-Paganon Sirano, Bird Gregory H, Wales Thomas E, Walensky Loren D

Discovery of a small molecule TLR3 agonist adjuvant

发现一种小分子TLR3激动剂佐剂

Branden Lee #,Danica Dong #,Etsuro Nanishi #,John Mark Awad ,Kimia Z Abedi,Yoshine Saito,Francesco Borriello,Soumik Barman,Byron Brook,Aisling Kelly,Manisha Menon,Constance Marques-Mourlet,Maansi V Gupta,Ida Lister,Chiwoo Oh,Kevin Lyskawa,Morgan Goetz,Kristina Walker,Wing Ki Cheng,Spencer E Brightman,Pankaj Sharma,Timothy R O'Meara,Katherine Chew,Daniel Vieira,Kevin Ryff,Cali Sweitzer,Sanya Thomas,Simon D van Haren,Matthew Pettengill ,Hyuk-Soo Seo,Sirano Dhe-Paganon,Wei Zhang,Ofer Levy ,David J Dowling    0

Targeting transcription factors through an IMiD independent zinc finger domain.

通过不依赖于IMiD的锌指结构域靶向转录因子

Liu Bee Hui, Liu Miao, Radhakrishnan Sridhar, Dai Meng-Yuan, Jaladanki Chaitanya Kumar, Gao Chong, Tang Jing Ping, Kumari Kalpana, Go Mei Lin, Vu Kim Anh L, Kwon Junsu, Seo Hyuk-Soo, Song Kijun, Tian Xi, Feng Li, Tan Justin L, Melkonian Arek V, Liu Zhaoji, Wulf Gerburg, Arthanari Haribabu, Qi Jun, Dhe-Paganon Sirano, Clohessy John G, Choong Yeu Khai, Sivaraman J, Fan Hao, Tenen Daniel G, Chai Li

Pharmacologic interrogation of USP28 cellular function in p53 signaling

通过药理学方法研究USP28在p53信号通路中的细胞功能

Bratt, Ariana S; Kilgas, Susan; Tarazona Guzman, Maria I; Magin, Robert S; Jaen Maisonet, Isabella; Starnbach, Cara A; Teh, Wei Pin; Varca, Anthony C; Hu, Bin; Tarazona Guzman, Esteban; Seo, Hyuk-Soo; Dhe-Paganon, Sirano; Girardi, Nicholas M; Adelmant, Guillaume; Marto, Jarrod A; Chowdhury, Dipanjan; Buhrlage, Sara J

Targeting NEDD9-SH3 with a Covalent Peptide Controls Endothelial Phenotype.

利用共价肽靶向NEDD9-SH3可控制内皮细胞表型

Samokhin Andriy O, Seo Hyuk-Soo, Leed Alison, Hajian Behnoush, Bird Gregory H, McKinney David C, Saha Progyaparamita, Daum Jacqueline, Moroco Jamie A, Yehl Jenna, Kornfilt David, Szczeniowski Anna, Petrunak Elyse, Horner Steven, Kalin Jay H, Leymarie Nancy, Kaushik Virendar K, Walensky Loren D, Cole Philip A, Oldham William M, Steinhauser Matthew L, Dhe-Paganon Sirano, Maron Bradley A

Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes

β细胞中m6A甲基转移酶METTL3的氧化还原调控控制着1型糖尿病的先天免疫反应

Dario F De Jesus,Zijie Zhang,Natalie K Brown,Xiaolu Li,Ling Xiao,Jiang Hu,Matthew J Gaffrey,Garrett Fogarty,Sevim Kahraman,Jiangbo Wei,Giorgio Basile,Tariq M Rana,Clayton Mathews,Alvin C Powers,Audrey V Parent,Mark A Atkinson,Sirano Dhe-Paganon,Decio L Eizirik,Wei-Jun Qian,Chuan He,Rohit N Kulkarni