日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Ester Prodrug NLRP3 Inflammasome Inhibitor NT-0796 is Brain Active due to Activation by Local Expression of Carboxylesterase-1

酯类前药 NLRP3 炎症小体抑制剂 NT-0796 因羧酸酯酶-1 的局部表达而被激活,从而具有脑活性。

Digby, Zsofia; Diamond, Christine; Wescott, Heather; Smolak, Pam; Thornton, Peter; Lindsay, Nicola; Gabel, Christopher A; Clarke, Nicholas; Watt, Alan P

Pharmacological Analysis of NLRP3 Inflammasome Inhibitor Sodium [(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl][(1-methyl-1H-pyrazol-4-yl)({[(2S)-oxolan-2-yl]methyl})sulfamoyl]azanide in Cellular and Mouse Models of Inflammation Provides a Translational Framework.

在细胞和小鼠炎症模型中对 NLRP3 炎症小体抑制剂钠 [(1,2,3,5,6,7-六氢-s-茚满-4-基)氨基甲酰基][(1-甲基-1H-吡唑-4-基)({[(2S)-氧杂环戊烷-2-基]甲基})磺酰胺酰基]氮化物进行药理学分析,为转化应用提供了框架

Doedens John R, Smolak Pamela, Nguyen MyTrang, Wescott Heather, Diamond Christine, Schooley Ken, Billinton Andy, Harrison David, Koller Beverly H, Watt Alan P, Gabel Christopher A

The neurokinin-1 receptor antagonist aprepitant in co-morbid alcohol dependence and posttraumatic stress disorder: a human experimental study

神经激肽-1受体拮抗剂阿瑞匹坦治疗合并酒精依赖和创伤后应激障碍:一项人体实验研究

Kwako, Laura E; George, David T; Schwandt, Melanie L; Spagnolo, Primavera A; Momenan, Reza; Hommer, Daniel W; Diamond, Christine A; Sinha, Rajita; Shaham, Yavin; Heilig, Markus