日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia.

致病性 Tau 突变导致自噬溶酶体功能障碍,从而限制额颞叶痴呆模型中 Tau 的降解。

Mirfakhar Farzaneh S, Marsh Jacob A, Sato Chihiro, Schache Kylie J, Minaya Miguel A, Dolle Roland E, Pak Stephen C, Silverman Gary A, Perlmutter David H, Macauley Shannon L, Karch Celeste M

Selective inhibition of ERO1α with M6766, a novel small-molecule inhibitor, prevents arterial thrombosis and ischemic stroke in mice.

使用新型小分子抑制剂 M6766 选择性抑制 ERO1α,可预防小鼠动脉血栓形成和缺血性中风

Wang Jinzhi, Kim Jae-Sung, Jha Vishwanath, Brown Gavriel, Lee Jingu, Bokorova Radka, Jin Bo-Ram, Ahmed Muteen, Castelblanco Esmeralda, Johnson Daniel, Prinsen Michael, Ilagan Ma Xenia G, Remedi Maria S, Razani Babak, Dolle Roland E, Cho Jaehyung

Hexagonal Bismuthene and Bismuth Nanoparticles for Light-To-Heat Conversion

六方铋烯和铋纳米粒子用于光热转换

Alcaraz, Marta; Congost-Escoin, Pau; Dolle, Christian; Canet-Ferrer, Josep; Abellán, Gonzalo

Targeting hepatocyte-specific SLC2A8 blocks hepatic steatosis and dissociates TCA cycle flux inhibition from glutamine anaplerosis

靶向肝细胞特异性SLC2A8可阻断肝脂肪变性,并将三羧酸循环通量抑制与谷氨酰胺补充代谢分离。

Adams, Joshua A; Zhang, Yiming; Sun, Jiameng; Tilston-Lunel, Andrew; Higgins, Cassandra B; Heitmeier, Monique; Ballentine, Sam; Tycksen, Eric; Dolle, Roland E; Hruz, Paul W; DeBosch, Brian J

Pyrimethamine and a potent analog inhibit NRF2 by suppressing one-carbon metabolism.

乙胺嘧啶及其强效类似物通过抑制一碳代谢来抑制 NRF2。

Chembo Julius, Bowman Brittany M, Lapak Kyle, Wilkerson Emily, Wamsley Nathan T, Paiboonrungruang Chorlada, Cho Kevin, Medcalf Matthew R, Wang Haining, Patti Gary J, Dolle Roland E, Chen Xiaoxin, Zolkind Paul, Major Michael B

Pyrimethamine and a potent analogue WCDD115 inhibit NRF2 by suppressing DHFR and one-carbon metabolism

乙胺嘧啶及其强效类似物 WCDD115 通过抑制 DHFR 和一碳代谢来抑制 NRF2

Julius Chembo, Brittany M Bowman, Kyle Lapak, Emily Wilkerson, Chorlada Paiboonrungruang, Kevin Cho, Matthew R Medcalf, Gary J Patti, Roland E Dolle, Xiaoxin Chen, Paul Zolkind, Michael B Major

Sequelae and reversal of age-dependent alterations in mitochondrial dynamics via autophagy enhancement in reprogrammed human neurons

通过自噬增强重编程人类神经元中线粒体动力学随年龄变化的后果和逆转

Klinman, Eva; Kwon, Ji-Sun; Dolle, Roland E; Pak, Stephen C; Silverman, Gary A; Perlmutter, David H; Yoo, Andrew S

Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer

膳食果糖通过器官间脂质转移间接促进肿瘤生长。

Fowle-Grider, Ronald; Rowles, Joe L 3rd; Shen, Isabel; Wang, Yahui; Schwaiger-Haber, Michaela; Dunham, Alden J; Jayachandran, Kay; Inkman, Matthew; Zahner, Michael; Naser, Fuad J; Jackstadt, Madelyn M; Spalding, Jonathan L; Chiang, Sarah; McCommis, Kyle S; Dolle, Roland E; Kramer, Eva T; Zimmerman, Sarah M; Souroullas, George P; Finck, Brian N; Shriver, Leah P; Kaufman, Charles K; Schwarz, Julie K; Zhang, Jin; Patti, Gary J

Addiction Consultation Services for Opioid Use Disorder Treatment Initiation and Engagement: A Randomized Clinical Trial

针对阿片类药物使用障碍治疗启动和参与的成瘾咨询服务:一项随机临床试验

McNeely, Jennifer; Wang, Scarlett S; Rostam Abadi, Yasna; Barron, Charles; Billings, John; Tarpey, Thaddeus; Fernando, Jasmine; Appleton, Noa; Fawole, Adetayo; Mazumdar, Medha; Weinstein, Zoe M; Kalyanaraman Marcello, Roopa; Dolle, Johanna; Cooke, Caroline; Siddiqui, Samira; King, Carla

Longitudinal modeling of human neuronal aging reveals the contribution of the RCAN1-TFEB pathway to Huntington's disease neurodegeneration

人类神经元衰老的纵向模型揭示了 RCAN1-TFEB 通路对亨廷顿病神经变性的贡献

Seong Won Lee #, Young Mi Oh #, Matheus B Victor, Yan Yang, Shawei Chen, Ilya Strunilin, Sonika Dahiya, Roland E Dolle, Stephen C Pak, Gary A Silverman, David H Perlmutter, Andrew S Yoo