Doubleday Peter F相关文献与解析，生知库

Characterizing the tumor suppressor activity of FLCN in Birt-Hogg-DubÃ© syndrome cell models through transcriptomic and proteomic analysis.

通过转录组学和蛋白质组学分析表征 FLCN 在 Birt-Hogg-Dubé 综合征细胞模型中的抑癌活性

Jones Rachel-Ann, Dunlop Elaine A, Champion Jesse D, Doubleday Peter F, Claessens Tijs, Jalali Zahra, Seifan Sara, Perry Iain A, Giles Peter, Harrison Oliver, Coull Barry J, Houweling Arjan C, Pause Arnim, Ballif Bryan A, Tee Andrew R

细胞生物学

发表日期：2025

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Rational Design, Synthesis, and Mechanism of (3S,4R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase

(3S,4R)-3-氨基-4-(二氟甲基)环戊-1-烯-1-羧酸的合理设计、合成及机理：采用二次去质子化策略提高人鸟氨酸氨基转移酶相对于GABA氨基转移酶的选择性

期刊:Journal of the American Chemical Society

影响因子:15.6

doi:10.1021/jacs.2c00924

Zhu, Wei; Butrin, Arseniy; Melani, Rafael D; Doubleday, Peter F; Ferreira, Glaucio Monteiro; Tavares, Mauricio T; Habeeb Mohammad, Thahani S; Beaupre, Brett A; Kelleher, Neil L; Moran, Graham R; Liu, Dali; Silverman, Richard B

Human

发表日期：2022

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Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase

(S)-3-氨基-4-(二氟亚甲基基)环己-1-烯-1-羧酸作为人鸟氨酸氨基转移酶选择性灭活剂的显著且出乎意料的机制

期刊:Journal of the American Chemical Society

影响因子:15.6

doi:10.1021/jacs.1c03572

Zhu, Wei; Doubleday, Peter F; Butrin, Arseniy; Weerawarna, Pathum M; Melani, Rafael D; Catlin, Daniel S; Dwight, Timothy A; Liu, Dali; Kelleher, Neil L; Silverman, Richard B

Human

发表日期：2021

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Spectrum of Apolipoprotein AI and Apolipoprotein AII Proteoforms and Their Associations With Indices of Cardiometabolic Health: The CARDIA Study

载脂蛋白AI和载脂蛋白AII蛋白异构体谱及其与心血管代谢健康指标的关联：CARDIA研究

期刊:Journal of the American Heart Association

影响因子:5.3

doi:10.1161/JAHA.120.019890

Wilkins, John T; Seckler, Henrique S; Rink, Jonathan; Compton, Philip D; Fornelli, Luca; Thaxton, C Shad; LeDuc, Rich; Jacobs, David; Doubleday, Peter F; Sniderman, Allan; Lloyd-Jones, Donald M; Kelleher, Neil L

代谢

发表日期：2021

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A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid

一个氟原子对两种γ-氨基丁酸环己烯类似物灭活人鸟氨酸氨基转移酶机制的显著影响

期刊:Journal of the American Chemical Society

影响因子:15.6

doi:10.1021/jacs.0c00193

Zhu, Wei; Doubleday, Peter F; Catlin, Daniel S; Weerawarna, Pathum M; Butrin, Arseniy; Shen, Sida; Wawrzak, Zdzislaw; Kelleher, Neil L; Liu, Dali; Silverman, Richard B

Human

发表日期：2020

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Mechanism-Based Design of 3-Amino-4-Halocyclopentenecarboxylic Acids as Inactivators of GABA Aminotransferase

基于机理的3-氨基-4-卤代环戊烯羧酸类化合物作为GABA氨基转移酶失活剂的设计

期刊:ACS Medicinal Chemistry Letters

影响因子:4

doi:10.1021/acsmedchemlett.9b00672

Shen, Sida; Doubleday, Peter F; Weerawarna, Pathum M; Zhu, Wei; Kelleher, Neil L; Silverman, Richard B

发表日期：2020

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Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype

阐明衰老相关分泌表型的蛋白质异构体动态变化

期刊:Journal of Proteome Research

影响因子:3.6

doi:10.1021/acs.jproteome.9b00739

Doubleday, Peter F; Fornelli, Luca; Kelleher, Neil L

Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk

对人类结直肠细胞和肿瘤中 KRAS4b 蛋白异构体的精确表征揭示了突变/修饰的相互作用

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.1716122115

Ntai, Ioanna; Fornelli, Luca; DeHart, Caroline J; Hutton, Josiah E; Doubleday, Peter F; LeDuc, Richard D; van Nispen, Alexandra J; Fellers, Ryan T; Whiteley, Gordon; Boja, Emily S; Rodriguez, Henry; Kelleher, Neil L

Top-down proteomics: Where we are, where we are going?

自上而下的蛋白质组学：我们现在在哪里，我们将走向何方？

期刊:Journal of Proteomics

影响因子:2.8

doi:10.1016/j.jprot.2017.02.002

Fornelli, Luca; Toby, Timothy K; Schachner, Luis F; Doubleday, Peter F; Srzentić, Kristina; DeHart, Caroline J; Kelleher, Neil L

发表日期：2018

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Multi-omics analysis reveals metabolic diversity underlying endothelial cell functions

多组学分析揭示了内皮细胞功能背后的代谢多样性

Characterizing the tumor suppressor activity of FLCN in Birt-Hogg-DubÃ© syndrome cell models through transcriptomic and proteomic analysis.

通过转录组学和蛋白质组学分析表征 FLCN 在 Birt-Hogg-Dubé 综合征细胞模型中的抑癌活性

Rational Design, Synthesis, and Mechanism of (3S,4R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase

(3S,4R)-3-氨基-4-(二氟甲基)环戊-1-烯-1-羧酸的合理设计、合成及机理：采用二次去质子化策略提高人鸟氨酸氨基转移酶相对于GABA氨基转移酶的选择性

Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase

(S)-3-氨基-4-(二氟亚甲基基)环己-1-烯-1-羧酸作为人鸟氨酸氨基转移酶选择性灭活剂的显著且出乎意料的机制

Spectrum of Apolipoprotein AI and Apolipoprotein AII Proteoforms and Their Associations With Indices of Cardiometabolic Health: The CARDIA Study

载脂蛋白AI和载脂蛋白AII蛋白异构体谱及其与心血管代谢健康指标的关联：CARDIA研究

A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid

一个氟原子对两种γ-氨基丁酸环己烯类似物灭活人鸟氨酸氨基转移酶机制的显著影响

Mechanism-Based Design of 3-Amino-4-Halocyclopentenecarboxylic Acids as Inactivators of GABA Aminotransferase

基于机理的3-氨基-4-卤代环戊烯羧酸类化合物作为GABA氨基转移酶失活剂的设计

Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype

阐明衰老相关分泌表型的蛋白质异构体动态变化

Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk

对人类结直肠细胞和肿瘤中 KRAS4b 蛋白异构体的精确表征揭示了突变/修饰的相互作用

Top-down proteomics: Where we are, where we are going?

自上而下的蛋白质组学：我们现在在哪里，我们将走向何方？