日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dual Inhibitors of SARS-CoV-2 3CL Protease and Human Cathepsin L Containing Glutamine Isosteres Are Anti-CoV-2 Agents.

含有谷氨酰胺同分异构体的SARS-CoV-2 3CL蛋白酶和人组织蛋白酶L双重抑制剂是抗CoV-2药物

Kumar Vivek, Zhu Jiyun, Chenna Bala C, Hoffpauir Zoe A, Rademacher Andrew, Rogers Ashley M, Tseng Chien-Te, Drelich Aleksandra, Farzandh Sharfa, Lamb Audrey L, Meek Thomas D

Rapid restoration of potent neutralization activity against the latest Omicron variant JN.1 via AI rational design and antibody engineering

通过人工智能理性设计和抗体工程,快速恢复针对最新奥密克戎变种 JN.1 的强效中和活性。

Liao, Yunji; Ma, Hang; Wang, Zhenyu; Wang, Shusheng; He, Yang; Chang, Yunsong; Zong, Huifang; Tang, Haoneng; Wang, Lei; Ke, Yong; Cai, Huiyu; Li, Ping; Tang, Jian; Chen, Hua; Drelich, Aleksandra; Peng, Bi-Hung; Hsu, Jason; Tat, Vivian; Tseng, Chien-Te K; Song, Jingjing; Yuan, Yunsheng; Wu, Mingyuan; Liu, Junjun; Yue, Yali; Zhang, Xiaoju; Wang, Ziqi; Yang, Li; Li, Jing; Ni, Xiaodan; Li, Hongshi; Xiang, Yuning; Bian, Yanlin; Zhang, Baohong; Yin, Haiyang; Dimitrov, Dimiter S; Gilly, John; Han, Lei; Jiang, Hua; Xie, Yueqing; Zhu, Jianwei

Characterizing temporal and global host innate immune responses against SARS-CoV-1 and -2 infection in pathologically relevant human lung epithelial cells.

对病理相关的人类肺上皮细胞中针对 SARS-CoV-1 和 -2 感染的宿主先天免疫反应的时间性和整体性进行表征

Tat Vivian Y, Drelich Aleksandra K, Huang Pinghan, Khanipov Kamil, Hsu Jason C, Widen Steven G, Tseng Chien-Te Kent, Golovko George

An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations.

口服生物利用度高的 SARS-CoV-2 主蛋白酶抑制剂表现出更高的亲和力和更低的突变敏感性

Westberg Michael, Su Yichi, Zou Xinzhi, Huang Pinghan, Rustagi Arjun, Garhyan Jaishree, Patel Puja Bhavesh, Fernandez Daniel, Wu Yan, Hao Chenzhou, Lo Chieh-Wen, Karim Marwah, Ning Lin, Beck Aimee, Saenkham-Huntsinger Panatda, Tat Vivian, Drelich Aleksandra, Peng Bi-Hung, Einav Shirit, Tseng Chien-Te K, Blish Catherine, Lin Michael Z

Generation of a humanized mAce2 and a conditional hACE2 mouse models permissive to SARS-COV-2 infection

构建人源化 mAce2 和条件性 hACE2 小鼠模型,使其能够感染 SARS-CoV-2 病毒

Song, I-Wen; Washington, Megan; Leynes, Carolina; Hsu, Jason; Rayavara, Kempaiah; Bae, Yangjin; Haelterman, Nele; Chen, Yuqing; Jiang, Ming-Ming; Drelich, Aleksandra; Tat, Vivian; Lanza, Denise G; Lorenzo, Isabel; Heaney, Jason D; Tseng, Chien-Te Kent; Lee, Brendan; Marom, Ronit

Comparison of replicating and nonreplicating vaccines against SARS-CoV-2

比较复制型和非复制型SARS-CoV-2疫苗

Mudrick, Haley E; Massey, Shane; McGlinch, Erin B; Parrett, Brian J; Hemsath, Jack R; Barry, Mary E; Rubin, Jeffrey D; Uzendu, Chisom; Hansen, Michael J; Erskine, Courtney L; Van Keulen, Virginia P; Drelich, Aleksandra; Panos, Joseph A; Fida, Madiha; Suh, Gina A; Peikert, Tobias; Block, Matthew S; Tseng, Chien-Te Kent; Olivier, Gloria R; Barry, Michael A

A Bacteriophage-Based, Highly Efficacious, Needle- and Adjuvant-Free, Mucosal COVID-19 Vaccine

基于噬菌体的高效无针无佐剂粘膜新冠疫苗

Zhu, Jingen; Jain, Swati; Sha, Jian; Batra, Himanshu; Ananthaswamy, Neeti; Kilgore, Paul B; Hendrix, Emily K; Hosakote, Yashoda M; Wu, Xiaorong; Olano, Juan P; Kayode, Adeyemi; Galindo, Cristi L; Banga, Simran; Drelich, Aleksandra; Tat, Vivian; Tseng, Chien-Te K; Chopra, Ashok K; Rao, Venigalla B

Self-Masked Aldehyde Inhibitors of Human Cathepsin L Are Potent Anti-CoV-2 Agents

人类组织蛋白酶L的自掩蔽醛类抑制剂是强效抗CoV-2药物

Zhu, Jiyun; Li, Linfeng; Drelich, Aleksandra; Chenna, Bala C; Mellott, Drake M; Taylor, Zane W; Tat, Vivian; Garcia, Christopher Z; Katzfuss, Ardala; Tseng, Chien-Te K; Meek, Thomas D

A universal bacteriophage T4 nanoparticle platform to design multiplex SARS-CoV-2 vaccine candidates by CRISPR engineering

利用CRISPR工程技术设计多种SARS-CoV-2候选疫苗的通用噬菌体T4纳米颗粒平台

Zhu, Jingen; Ananthaswamy, Neeti; Jain, Swati; Batra, Himanshu; Tang, Wei-Chun; Lewry, Douglass A; Richards, Michael L; David, Sunil A; Kilgore, Paul B; Sha, Jian; Drelich, Aleksandra; Tseng, Chien-Te K; Chopra, Ashok K; Rao, Venigalla B

A Quick Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors*

快速合成多种高效SARS-CoV-2主蛋白酶抑制剂的途径*

Yang, Kai S; Ma, Xinyu R; Ma, Yuying; Alugubelli, Yugendar R; Scott, Danielle A; Vatansever, Erol C; Drelich, Aleksandra K; Sankaran, Banumathi; Geng, Zhi Z; Blankenship, Lauren R; Ward, Hannah E; Sheng, Yan J; Hsu, Jason C; Kratch, Kaci C; Zhao, Baoyu; Hayatshahi, Hamed S; Liu, Jin; Li, Pingwei; Fierke, Carol A; Tseng, Chien-Te K; Xu, Shiqing; Liu, Wenshe Ray