日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

LRRK2 kinase mediates increased GCase activity in microglia in response to IFNγ-induced proinflammatory stimulation.

LRRK2 激酶介导小胶质细胞中 GCase 活性增加,以响应 IFNγ 诱导的促炎刺激。

MacDougall Emma J, Chen Carol X-Q, Deneault Eric, You Zhipeng, Kalaydjian David, Abdian Narges, Durcan Thomas M, Senkevich Konstantin, Gan-Or Ziv, Fon Edward A

SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids.

SNCA 三倍体在人类中脑类器官发生神经退行性变之前会破坏蛋白质稳态和细胞外结构。

Statoulla Elpida, Zafeiri Maria, Chalkiadaki Kleanthi, Voudouri Georgia, Gkika Karmel S, Papazoglou Christos, Durcan Thomas M, Khoutorsky Arkady, Jafarnejad Seyed Mehdi, Maguire Sarah, Dityatev Alexander, Gkogkas Christos G

Age and Maturation Stage Linked Consequences of Fibrinogen on Human Oligodendroglia

纤维蛋白原对人类少突胶质细胞的年龄和成熟阶段相关影响

Blaszczyk, Gabriela J; Weng, Chao; Mohammadnia, Abdulshakour; Cui, Qiao-Ling; Giurleo, Arianna; Groh, Adam M R; Plouffe, Chloe; Sirois, Julien; Piscopo, Valerio E C; Yaqubi, Moein; Taqvi, Asad; Cassidy, Erin; Martin, Liam Callahan; Hall, Jeffery A; Dudley, Roy W R; Srour, Myriam; Zandee, Stephanie E J; Klement, Wendy; Larouche, Sandra; Prat, Alexandre; Durcan, Thomas M; Stratton, Jo Anne; Antel, Jack P; Moore, G R Wayne

Neural cell state modulation by PARK2 and dopaminergic neuroprotection by small molecule Parkin agonism

PARK2 对神经细胞状态的调节以及小分子 Parkin 激动剂的多巴胺能神经保护作用

Gong, Yongxing; Bayati, Armin; Alban, Tyler J; Parthasarathy, Prerana; Zhou, Fang; Makarov, Vladimir; Zhao, Yuhang; Su, Chienwen; Schumacher, Jackson G; Singh, Vijay; Volpicelli-Daley, Laura A; Luo, Wen; Durcan, Thomas M; Dutta, Shovan; Schwarzschild, Michael A; Johnston, Jennifer A; Chan, Timothy A; Chen, Xiqun

Activation of endogenous PRKN by structural derepression is linked to increased turnover of the E3 ubiquitin ligase.

结构去抑制激活内源性 PRKN 与 E3 泛素连接酶的周转率增加有关。

Fiesel Fabienne C, Bustillos Bernardo A, Watzlawik Jens O, Chen Carol X Q, Berryer Martin H, Zhang Jiazhen, Boneski Paige K, Hayes Caleb S, Bredenberg Jenny M, Deneault Eric, You Zhipeng, Abdien Narges, Aprahamian Nathalia, Goldsmith Taylor M, Baninameh Zahra, Cocker Liam T, Zhang Haonan, Goldberg Matthew S, Fon Edward A, Trempe Jean-François, Virdee Satpal, Durcan Thomas M, Springer Wolfdieter

Neuraminidase 1 secondary deficiency contributes to CNS pathology in neurological mucopolysaccharidoses via brain protein hypersialylation

神经氨酸酶 1 继发性缺乏症通过脑蛋白过度唾液酸化作用导致神经系统粘多糖贮积症的中枢神经系统病变。

Xu, TianMeng; Heon-Roberts, Rachel; Moore, Travis; Dubot, Patricia; Pan, Xuefang; Guo, Tianlin; Cairo, Christopher W; Holley, Rebecca J; Bigger, Brian; Durcan, Thomas M; Levade, Thierry; Ausseil, Jerôme; Amilhon, Bénédicte; Gorelik, Alexei; Nagar, Bhushan; Khan, Shaukat; Tomatsu, Shunji; Sturiale, Luisa; Palmigiano, Angelo; Röckle, Iris; Thiesler, Hauke; Hildebrandt, Herbert; Garozzo, Domenico; Pshezhetsky, Alexey V

Pro-Inflammatory Molecules Implicated in Multiple Sclerosis Divert the Development of Human Oligodendrocyte Lineage Cells

与多发性硬化症相关的促炎分子会改变人类少突胶质细胞谱系细胞的发育

Blaszczyk, Gabriela J; Mohammadnia, Abdulshakour; Piscopo, Valerio E C; Sirois, Julien; Cui, Qiao-Ling; Yaqubi, Moein; Durcan, Thomas M; Schneider, Raphael; Antel, Jack P

Discovery of MDI-114215: A Potent and Selective LIMK Inhibitor To Treat Fragile X Syndrome.

MDI-114215 的发现:一种强效且选择性的 LIMK 抑制剂,可用于治疗脆性 X 综合征

Baldwin Alex G, Foley David W, Collins Ross, Lee Hyunah, Jones D Heulyn, Wahab Ben, Waters Loren, Pedder Josephine, Paine Marie, Feng Gui Jie, Privitera Lucia, Ashall-Kelly Alexander, Thomas Carys, Gillespie Jason A, Schino Lauramariú, Belelli Delia, Rocha Cecilia, Maussion Gilles, Krahn Andrea I, Durcan Thomas M, Elkins Jonathan M, Lambert Jeremy J, Atack John R, Ward Simon E

Evaluation of Additive Neuroprotective Effect of Combination Therapy for Parkinson's Disease Using In Vitro Models.

利用体外模型评价联合疗法对帕金森病神经保护作用的叠加效应

Shtilbans Alexander, Esneault Elise, Simon Florian, Mazzulli Joseph R, Quiriconi Drew J, Rom Dror, Reintsch Wolfgang E, Krahn Andrea I, Durcan Thomas M

14-3-3ζ allows for adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation.

14-3-3ζ 通过在脂肪细胞分化的早期阶段调节染色质可及性来促进脂肪生成

Rial Sabri A, You Zhipeng, Vivoli Alexis, Paré Fédéric, Sean Daphné, AlKhoury Amal, Lavoie Geneviève, Civelek Mete, Martinez-Sanchez Aida, Roux Philippe P, Durcan Thomas M, Lim Gareth E