日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Protection Against Cellular Toxicity from Rotenone Treatment by the Neuroprotective, Novel Multifunctional Antiparkinsonian Drug D-512

新型多功能抗帕金森病神经保护药物D-512可保护细胞免受鱼藤酮治疗引起的毒性作用

Ravipati, Pranay; Xu, Liping; Yedlapudi, Deepthi; Dutta, Aloke K

Robustness of the Centiloid scale to target and reference regions calculated with a commercial software using [(18)F]flutemetamol PET images

使用商业软件和[(18)F]氟他莫尔PET图像计算Centiloid标度对目标区域和参考区域的稳健性

Armstrong, Christopher; Luo, Dan; Gretzinger, Anna; Pandey, Deepti; Lipchik, Andrew; Todi, Sokol V; Dutta, Aloke K; Honig, Lawrence S; Kang, Min Suk; Lamoureux, Jennifer; Marder, Karen; Sun, Xianwei; Badachhape, Andrew A; Reid, Terry‐Elinor; Chin, Jeannie; Shulman, Joshua M; Annapragada, Ananth; Lowe, Henry; Toyang, Ngeh; Tanifum, Eric; Fahmi, Rachid; Bollack, Ariane; Battle, Mark R; Farrar, Gill; Spottiswoode, Bruce

Bivalent dopamine agonists with co-operative binding and functional activities at dopamine D2 receptors, modulate aggregation and toxicity of alpha synuclein protein

具有协同结合能力和多巴胺D2受体功能活性的二价多巴胺激动剂,可调节α-突触核蛋白的聚集和毒性。

Dinda, Bidyut; Das, Banibrata; Biswas, Swati; Sharma, Horrick; Armstrong, Christopher; Yedlapudi, Deepthi; Antonio, Tamara; Reith, Maarten; Dutta, Aloke K

D-578, an orally active triple monoamine reuptake inhibitor, displays antidepressant and anti-PTSD like effects in rats

D-578 是一种口服有效的三重单胺再摄取抑制剂,在大鼠中表现出抗抑郁和抗创伤后应激障碍样作用。

Dutta, Aloke K; Santra, Soumava; Harutyunyan, Arman; Das, Banibrata; Lisieski, Michael J; Xu, Liping; Antonio, Tamara; Reith, Maarten E A; Perrine, Shane A

Assessment of Protective Role of Multifunctional Dopamine Agonist D-512 Against Oxidative Stress Produced by Depletion of Glutathione in PC12 Cells: Implication in Neuroprotective Therapy for Parkinson's Disease

评估多功能多巴胺激动剂D-512对PC12细胞中谷胱甘肽耗竭引起的氧化应激的保护作用:在帕金森病神经保护治疗中的应用

Voshavar, Chandrashekhar; Shah, Mrudang; Xu, Liping; Dutta, Aloke K

Understanding the Structural Requirements of Hybrid (S)-6-((2-(4-Phenylpiperazin-1-yl)ethyl)(propyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol and its Analogs as D2/D3 Receptor Ligands: A Three-Dimensional Quantitative Structure-Activity Relationship (3D QSAR) Investigation

理解杂合体(S)-6-((2-(4-苯基哌嗪-1-基)乙基)(丙基)氨基)-5,6,7,8-四氢萘-1-醇及其类似物作为D2/D3受体配体的结构要求:三维定量构效关系(3D QSAR)研究

Modi, Gyan; Sharma, Horrick; Kharkar, Prashant S; Dutta, Aloke K

Structural exploration of (3S,6S)-6-benzhydryl-N-benzyltetrahydro-2H-pyran-3-amine analogues: identification of potent triple monoamine reuptake inhibitors as potential antidepressants

(3S,6S)-6-二苯甲基-N-苄基四氢-2H-吡喃-3-胺类似物的结构探索:鉴定强效的三重单胺再摄取抑制剂作为潜在的抗抑郁药

Santra, Soumava; Gogoi, Sanjib; Gopishetty, Bhaskar; Antonio, Tamara; Zhen, Juan; Reith, Maarten E A; Dutta, Aloke K

Characterization of [³H]CFT binding to the norepinephrine transporter suggests that binding of CFT and nisoxetine is not mutually exclusive.

[³H]CFT 与去甲肾上腺素转运蛋白结合的特征表明 CFT 和尼索西汀的结合并不相互排斥

Zhen Juan, Ali Solav, Dutta Aloke K, Reith Maarten E A

Dopamine D₂/D₃ agonists with potent iron chelation, antioxidant and neuroprotective properties: potential implication in symptomatic and neuroprotective treatment of Parkinson's disease

具有强效铁螯合、抗氧化和神经保护特性的多巴胺D₂/D₃激动剂:在帕金森病症状治疗和神经保护治疗中的潜在应用

Gogoi, Sanjib; Antonio, Tamara; Rajagopalan, Subramanian; Reith, Maarten; Andersen, Julie; Dutta, Aloke K

Synthesis and biological characterization of (3R,4R)-4-(2-(benzhydryloxy)ethyl)-1-((R)-2-hydroxy-2-phenylethyl)-piperidin-3-ol and its stereoisomers for activity toward monoamine transporters

合成并表征(3R,4R)-4-(2-(二苯甲氧基)乙基)-1-((R)-2-羟基-2-苯基乙基)-哌啶-3-醇及其立体异构体对单胺转运蛋白的活性

Kharkar, Prashant S; Batman, Angela M; Zhen, Juan; Beardsley, Patrick M; Reith, Maarten E A; Dutta, Aloke K