Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2
衰老成纤维细胞脂质代谢的变化通过脂肪酸转运蛋白 FATP2 诱导年龄依赖性黑色素瘤细胞对靶向治疗产生耐药性
期刊:Cancer Discovery
影响因子:29.7
doi:10.1158/2159-8290.CD-20-0329
Gretchen M Alicea, Vito W Rebecca, Aaron R Goldman, Mitchell E Fane, Stephen M Douglass, Reeti Behera, Marie R Webster, Curtis H Kugel 3rd, Brett L Ecker, M Cecilia Caino, Andrew V Kossenkov, Hsin-Yao Tang, Dennie T Frederick, Keith T Flaherty, Xiaowei Xu, Qin Liu, Dmitry I Gabrilovich, Meenhard Her
代谢
信号转导
肿瘤
黑色素瘤
成纤维细胞
Senescence