日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Large pH oscillations promote host defense against human airways infection

pH 值大幅波动促进宿主防御人类呼吸道感染

Dusik Kim, Jie Liao, Nathan B Scales, Carolina Martini, Xiaojie Luan, Asmahan Abu-Arish, Renaud Robert, Yishan Luo, Geoffrey A McKay, Dao Nguyen, Marc A Tewfik, Charles D Poirier, Elias Matouk, Juan P Ianowski, Saul Frenkiel, John W Hanrahan

A Precision Medicine Approach to Optimize Modulator Therapy for Rare CFTR Folding Mutants

针对罕见 CFTR 折叠突变体优化调节剂疗法的精准医疗方法

Guido Veit, Tony Velkov, Haijin Xu, Nathalie Vadeboncoeur, Lara Bilodeau, Elias Matouk, Gergely L Lukacs

Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination

通过 elexacaftor-tezacaftor-ivacaftor (Trikafta) 组合对 F508del 和罕见 CFTR 突变体进行变构折叠校正

Guido Veit, Ariel Roldan, Mark A Hancock, Dillon F Da Fonte, Haijin Xu, Maytham Hussein, Saul Frenkiel, Elias Matouk, Tony Velkov, Gergely L Lukacs

Structure-guided combination therapy to potently improve the function of mutant CFTRs

结构引导联合疗法有效改善突变 CFTR 的功能

Guido Veit, Haijin Xu, Elise Dreano, Radu G Avramescu, Miklos Bagdany, Lenore K Beitel, Ariel Roldan, Mark A Hancock, Cecilia Lay, Wei Li, Katelin Morin, Sandra Gao, Puiying A Mak, Edward Ainscow, Anthony P Orth, Peter McNamara, Aleksander Edelman, Saul Frenkiel, Elias Matouk, Isabelle Sermet-Gaudel