Macrophage Therapy for Acute Liver Injury (MAIL): a study protocol for a phase 1 randomised, open-label, dose-escalation study to evaluate safety, tolerability and activity of allogeneic alternatively activated macrophages in patients with paracetamol-induced acute liver injury in the UK
巨噬细胞疗法治疗急性肝损伤(MAIL):一项在英国开展的1期随机、开放标签、剂量递增研究方案,旨在评估同种异体替代激活巨噬细胞治疗对乙酰氨基酚引起的急性肝损伤患者的安全性、耐受性和活性。
期刊:BMJ Open
影响因子:2.3
doi:10.1136/bmjopen-2024-089417
Humphries, Christopher; Addison, Melisande; Aithal, Guruprasad; Boyd, Julia; Briody, Lesley; Campbell, John D M; Candela, Maria Elena; Clarke, Ellise; Coulson, James; Downing-James, Nicholas; Fontana, Robert John; Geddes, Ailsa; Grahamslaw, Julia; Grant, Alison; Heye, Anna; Hutchinson, James A; Jones, Ashley; Mitchell, Fiona; Moore, Joanna; Riddell, Alice; Rodriguez, Aryelly; Thomas, Angela; Tucker, Garry; Walker, Kim; Weir, Christopher J; Woods, Rachel; Zahra, Sharon; Forbes, Stuart J; Dear, James W
巨噬细胞
巨噬细胞
肝损伤
细胞生物学
毒理研究
免疫/内分泌