日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

LUNAR LNP delivery of CFTR mRNA restores channel function and improves mucociliary clearance in ferret cystic fibrosis airways

LUNAR LNP递送CFTR mRNA可恢复雪貂囊性纤维化气道中的通道功能并改善黏液纤毛清除功能。

Liu, Xiaoming; Campos-Gomez, Javier; Luo, Meihui; Ma, Jia; Chen, Han-Chung; Shukla, Sourabh; Wu, Shuang; Snow, Guy; Pei, Yihua; Boehme, Stefen A; Geller, David E; Rowe, Steve M; Engelhardt, John F

Ionocyte CFTR Coordinates Chloride Absorption and Secretion to Balance Airway Fluid

离子细胞CFTR协调氯离子的吸收和分泌以平衡气道液

Yuan, Feng; Hajibabazade, Javahir; Yi, Yaling; Thompson, Adriane E; Fu, Lianwu; Zhang, Yan; Wang, Ziyuan; Tang, Yinghua; Gasser, Grace N; Hao, Meihua; Yan, Ziying; Sun, Xingshen; Engelhardt, John F

Ferret model of bleomycin-induced lung injury shares features of human idiopathic pulmonary fibrosis

雪貂博来霉素诱导肺损伤模型与人类特发性肺纤维化具有相似特征

Wu, Shuang; Driver, Ian; Luo, Meihui; Miyazaki, Hikaru; Shambhu, Smitha; Popov, Dimitry; Yang, Liyuan; Wang, Jing; Ma, Jia; Guo, Junfeng; Atha, Jarron; Tata, Aleksandra; Hoffman, Eric A; Wang, Yujiong; Tata, Purushothama Rao; Jensen, Martin B; Engelhardt, John F; Sontake, Vishwaraj; Liu, Xiaoming

Novel Cystic Fibrosis Ferret Model Enables Visualization of CFTR Expression Cells and Genetic CFTR Reactivation.

新型囊性纤维化雪貂模型可实现 CFTR 表达细胞和 CFTR 基因重新激活的可视化

Yuan Feng, Sun Xingshen, Park Soo Yeun, Tang Yinghua, Feng Zehua, Ebadi Mehrnoosh, Yi Yaling, Thompson Adriane E, Karippaparambil Joseph D, Engelhardt John F, Yan Ziying

Recombinant Adeno-Associated Virus Vector Mediated Gene Editing in Proliferating and Polarized Cultures of Human Airway Epithelial Cells.

重组腺相关病毒载体介导的人呼吸道上皮细胞增殖和极化培养物中的基因编辑

Park Soo Yeun, Feng Zehua, Choi Soon H, Zhang Xiujuan, Tang Yinghua, Gasser Grace N, Richart Donovan, Yuan Feng, Qiu Jianming, Engelhardt John F, Yan Ziying

A Versatile Reporter Platform for Evaluating HDR- and NHEJ-Based Genome Editing in Airway Epithelial Cell Cultures Using an rAAV Vector

利用rAAV载体构建的多功能报告基因平台,用于评估气道上皮细胞培养物中基于HDR和NHEJ的基因组编辑。

Park, Soo Yeun; Feng, Zehua; Zhang, Xiujuan; Tang, Yinghua; Richart, Donovan; Vorhies, Kai E; Qiu, Jianming; Engelhardt, John F; Yan, Ziying

Isolation and Culture of Ferret Airway Stem Cells.

雪貂气道干细胞的分离与培养

Yan Ziying, Engelhardt John F, Yuan Feng

Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy.

人工智能指导的脂质纳米颗粒设计用于肺部基因治疗

Witten Jacob, Raji Idris, Manan Rajith S, Beyer Emily, Bartlett Sandra, Tang Yinghua, Ebadi Mehrnoosh, Lei Junying, Nguyen Dien, Oladimeji Favour, Jiang Allen Yujie, MacDonald Elise, Hu Yizong, Mughal Haseeb, Self Ava, Collins Evan, Yan Ziying, Engelhardt John F, Langer Robert, Anderson Daniel G

Durable transgene expression and efficient re-administration after rAAV2.5T-mediated fCFTRΔR gene delivery to adult ferret lungs

rAAV2.5T介导的fCFTRΔR基因递送至成年雪貂肺部后,转基因表达持久且可有效重复给药

Tang, Yinghua; Ebadi, Mehrnoosh; Lei, Junying; Feng, Zehua; Fakhari, Shahab; Wu, Peipei; Smith, Mark D; Limberis, Maria P; Kolbeck, Roland; Excoffon, Katherine J; Yan, Ziying; Engelhardt, John F

Understanding and addressing the needs of people with cystic fibrosis in the era of CFTR modulator therapy

在CFTR调节剂疗法时代,了解并满足囊性纤维化患者的需求至关重要。

Hisert, Katherine B; Birket, Susan E; Clancy, John Paul; Downey, Damian G; Engelhardt, John F; Fajac, Isabelle; Gray, Robert D; Lachowicz-Scroggins, Marrah E; Mayer-Hamblett, Nicole; Thibodeau, Patrick; Tuggle, Katherine L; Wainwright, Claire E; De Boeck, Kris