日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Reduction of therapeutic antibody self-association using yeast-display selections and machine learning

利用酵母展示选择和机器学习减少治疗性抗体的自我关联

Emily K Makowski, Hongwei Chen, Matthew Lambert, Eric M Bennett, Nicole S Eschmann, Yulei Zhang, Jennifer M Zupancic, Alec A Desai, Matthew D Smith, Wenjia Lou, Amendra Fernando, Timothy Tully, Christopher J Gallo, Laura Lin, Peter M Tessier

Combining random mutagenesis, structure-guided design and next-generation sequencing to mitigate polyreactivity of an anti-IL-21R antibody

结合随机诱变、结构引导设计和下一代测序来减轻抗 IL-21R 抗体的多反应性

Sharon M Campbell, Joseph DeBartolo, James R Apgar, Lydia Mosyak, Virginie McManus, Sonia Beyer, Eric M Bennett, Matthew Lambert, Orla Cunningham

Modeling and mitigation of high-concentration antibody viscosity through structure-based computer-aided protein design

通过基于结构的计算机辅助蛋白质设计对高浓度抗体粘度进行建模和缓解

James R Apgar, Amy S P Tam, Rhady Sorm, Sybille Moesta, Amy C King, Han Yang, Kerry Kelleher, Denise Murphy, Aaron M D'Antona, Guoying Yan, Xiaotian Zhong, Linette Rodriguez, Weijun Ma, Darren E Ferguson, Gregory J Carven, Eric M Bennett, Laura Lin

A genome-wide scan for common variants affecting the rate of age-related cognitive decline

针对影响年龄相关认知衰退速度的常见变异进行全基因组扫描

De Jager, Philip L; Shulman, Joshua M; Chibnik, Lori B; Keenan, Brendan T; Raj, Towfique; Wilson, Robert S; Yu, Lei; Leurgans, Sue E; Tran, Dong; Aubin, Cristin; Anderson, Christopher D; Biffi, Alessandro; Corneveaux, Jason J; Huentelman, Matthew J; Rosand, Jonathan; Daly, Mark J; Myers, Amanda J; Reiman, Eric M; Bennett, David A; Evans, Denis A

Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes

荟萃分析证实 CR1、CLU 和 PICALM 是阿尔茨海默病风险位点,并揭示了它们与 APOE 基因型的相互作用。

Jun, Gyungah; Naj, Adam C; Beecham, Gary W; Wang, Li-San; Buros, Jacqueline; Gallins, Paul J; Buxbaum, Joseph D; Ertekin-Taner, Nilufer; Fallin, M Daniele; Friedland, Robert; Inzelberg, Rivka; Kramer, Patricia; Rogaeva, Ekaterina; St George-Hyslop, Peter; Cantwell, Laura B; Dombroski, Beth A; Saykin, Andrew J; Reiman, Eric M; Bennett, David A; Morris, John C; Lunetta, Kathryn L; Martin, Eden R; Montine, Thomas J; Goate, Alison M; Blacker, Deborah; Tsuang, Debby W; Beekly, Duane; Cupples, L Adrienne; Hakonarson, Hakon; Kukull, Walter; Foroud, Tatiana M; Haines, Jonathan; Mayeux, Richard; Farrer, Lindsay A; Pericak-Vance, Margaret A; Schellenberg, Gerard D

Inhibition of siderophore biosynthesis in Mycobacterium tuberculosis with nucleoside bisubstrate analogues: structure-activity relationships of the nucleobase domain of 5'-O-[N-(salicyl)sulfamoyl]adenosine

用核苷双底物类似物抑制结核分枝杆菌中的铁载体生物合成:5'-O-[N-(水杨基)氨磺酰基]腺苷核碱基结构域的结构-活性关系

João Neres, Nicholas P Labello, Ravindranadh V Somu, Helena I Boshoff, Daniel J Wilson, Jagadeshwar Vannada, Liqiang Chen, Clifton E Barry 3rd, Eric M Bennett, Courtney C Aldrich

5'-O-[(N-acyl)sulfamoyl]adenosines as antitubercular agents that inhibit MbtA: an adenylation enzyme required for siderophore biosynthesis of the mycobactins

5'-O-[(N-酰基)氨磺酰基]腺苷作为抗结核药物可抑制 MbtA:一种分枝杆菌铁载体生物合成所需的腺苷酸化酶

Chunhua Qiao, Amol Gupte, Helena I Boshoff, Daniel J Wilson, Eric M Bennett, Ravindranadh V Somu, Clifton E Barry 3rd, Courtney C Aldrich