日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Characterizing the impact of MLL fusion variants and fusion partners on leukemia plasticity using a human CRISPR-engineered MLL-rearranged leukemia model

利用人源 CRISPR 基因编辑的 MLL 重排白血病模型,研究 MLL 融合变体及其融合伴侣对白血病可塑性的影响

Radszuweit, Pia; Fitzel, Rahel; Bruestl, Sarah; Hentrich, Thomas; Korkmaz, Fulya; Mankel, Barbara; González-Menéndez, Irene; Rudat, Saskia; Marschalek, Rolf; Erkner, Estelle; Keppeler, Hildegard; Schairer, Rebekka; Luib, Luise; Mezger, Markus; Quintanilla-Martinez, Leticia; Schulze-Hentrich, Julia; Lengerke, Claudia; Schneidawind, Dominik; Schneidawind, Corina

Bridging the marrow: a co-culture-platform of leukemia cells and MS5-derived stromal cells or adipocytes.

连接骨髓:白血病细胞与 MS5 衍生基质细胞或脂肪细胞的共培养平台

Zinngrebe Julia, Brenner Elena Dorothea, Schlichtig Ferdinand, Stifel Ulrich, Tews Daniel, Falk Jana, Schlotter Dominik, Fitzel Rahel, Meyer Lüder-Hinrich, Debatin Klaus-Michael, Fischer-Posovszky Pamela

Protocol for CRISPR-Cas9-mediated induction of KMT2A rearrangements in cell line and umbilical cord blood hematopoietic stem and progenitor cells

利用 CRISPR-Cas9 介导的 KMT2A 重排诱导细胞系和脐带血造血干细胞及祖细胞的实验方案

Tamara Benz ,Patrizia Larghero ,Claus Meyer ,Marcel Müller ,Dörthe Brüggmann ,Anna-Elisabeth Hentrich ,Frank Louwen ,Estelle Erkner ,Rahel Fitzel ,Corina Schneidawind ,Rolf Marschalek

The RORɣ/SREBP2 pathway is a master regulator of cholesterol metabolism and serves as potential therapeutic target in t(4;11) leukemia

RORɣ/SREBP2 通路是胆固醇代谢的主要调节器,可作为 t(4;11) 白血病的潜在治疗靶点

Estelle Erkner, Thomas Hentrich, Rebekka Schairer, Rahel Fitzel, Kathy-Ann Secker-Grob, Johan Jeong, Hildegard Keppeler, Fulya Korkmaz, Julia M Schulze-Hentrich, Claudia Lengerke, Dominik Schneidawind, Corina Schneidawind

Treatment response of advanced HNSCC towards immune checkpoint inhibition is associated with an activated effector memory T cell phenotype

晚期头颈部鳞状细胞癌对免疫检查点抑制剂的治疗反应与活化的效应记忆T细胞表型相关

Schumacher, Max; Beer, Sina; Moraes Ribeiro, Emmanuelle; Korkmaz, Fulya; Keppeler, Hildegard; Fitzel, Rahel; Erkner, Estelle; Radszuweit, Pia; Lengerke, Claudia; Schneidawind, Corina; Hoefert, Sebastian; Mauz, Paul Stefan; Schneidawind, Dominik

Uncovering NOTCH1 as a Promising Target in the Treatment of MLL-Rearranged Leukemia

发现 NOTCH1 是治疗 MLL 重排白血病的一个有前景的靶点

Jacqueline Fischer ,Estelle Erkner ,Rahel Fitzel ,Pia Radszuweit ,Hildegard Keppeler ,Fulya Korkmaz ,Giovanni Roti ,Claudia Lengerke ,Dominik Schneidawind ,Corina Schneidawind

Targeting MYC in combination with epigenetic regulators induces synergistic anti-leukemic effects in MLLr leukemia and simultaneously improves immunity

以 MYC 为靶点,结合表观遗传调节剂,可在 MLLr 白血病中产生协同抗白血病作用,同时提高免疫力

Rahel Fitzel, Kathy-Ann Secker-Grob, Hildegard Keppeler, Fulya Korkmaz, Rebekka Schairer, Estelle Erkner, Dominik Schneidawind, Claudia Lengerke, Thomas Hentrich, Julia M Schulze-Hentrich, Corina Schneidawind

Considering the Experimental use of Temozolomide in Glioblastoma Research.

考虑替莫唑胺在胶质母细胞瘤研究中的实验性应用

Herbener Verena J, Burster Timo, Goreth Alicia, Pruss Maximilian, von Bandemer Hélène, Baisch Tim, Fitzel Rahel, Siegelin Markus D, Karpel-Massler Georg, Debatin Klaus-Michael, Westhoff Mike-Andrew, Strobel Hannah