Gabel Christopher相关文献与解析，生知库

Mice humanized by syntenic replacement with full-length NLRP3 disease-associated variants model the clinical cryopyrinopathy continuum

通过将全长NLRP3疾病相关变异体进行同源替换而人源化的小鼠模型模拟了临床冷吡啉病连续谱。

期刊:JCI Insight

影响因子:6.1

doi:10.1172/jci.insight.194677

Snouwaert, John N; Nguyen, MyTrang; Gabel, Christopher A; Aksentijevich, Ivona; Ting, Jenny P-Y; Koller, Beverly H

Ester Prodrug NLRP3 Inflammasome Inhibitor NT-0796 is Brain Active due to Activation by Local Expression of Carboxylesterase-1

酯类前药 NLRP3 炎症小体抑制剂 NT-0796 因羧酸酯酶-1 的局部表达而被激活，从而具有脑活性。

期刊:ACS Chemical Neuroscience

影响因子:3.9

doi:10.1021/acschemneuro.5c00843

Digby, Zsofia; Diamond, Christine; Wescott, Heather; Smolak, Pam; Thornton, Peter; Lindsay, Nicola; Gabel, Christopher A; Clarke, Nicholas; Watt, Alan P

Neuronal Dynamics During Isoflurane Induction in Caenorhabditis elegans

异氟烷诱导秀丽隐杆线虫神经元动力学

期刊:

影响因子:

doi:10.64898/2026.03.31.715586

White, Hamilton A; Bosinski, Cameron R; Gabel, Christopher V; Connor, Christopher W

C. elegans

发表日期：2026

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Profile of NT-0527, a brain penetrant NLRP3 Inflammasome inhibitor suitable as an in vivo tool compound for neuroinflammatory disorders.

NT-0527 是一种可穿透血脑屏障的 NLRP3 炎症小体抑制剂，适用于作为神经炎症性疾病的体内治疗药物

期刊:RSC Medicinal Chemistry

影响因子:3.6

doi:10.1039/d5md00639b

Harrison David, Billinton Andy, Bock Mark G, Clarke Nicholas P, Digby Zsofia, Gabel Christopher A, Lindsay Nicola, Reader ValÃ©rie, Scanlon Jane, Smolak Pamela, Thornton Peter, Wescott Heather, Watt Alan P

Anesthesia isn't sleep: The neuronal dynamics of immobility in isoflurane-anesthetized C. elegans differ from the activity patterns of previously established sleep-like quiescent states

麻醉并非睡眠：异氟烷麻醉的秀丽隐杆线虫静止状态下的神经元动力学与先前建立的类似睡眠的静息状态的活动模式不同

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0324323

Chang, Andrew S; Mazuera, Laura; Gabel, Christopher V; Connor, Christopher W

IPSC-based modeling of resiliency in centenarians reveals longevity-specific signatures

基于IPSC的百岁老人韧性建模揭示了长寿特有的特征

期刊:

影响因子:

doi:10.1101/2025.10.10.681757

Dowrey, Todd W; Cranston, Samuel F; Skvir, Nicholas J; Lok, Yvonne; Bock, Payton; Kharitonova, Elizabeth K; MacDonald, Elise; Zeldich, Ella; Gabel, Christopher V; Tyshkovskiy, Alexander; Monti, Stefano; Gladyshev, Vadim N; Sebastiani, Paola; Perls, Thomas T; Andersen, Stacy; Murphy, George James

发表日期：2025

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CaNetiCs - An Open-Source Toolbox for Standardized Dimensionality Reduction of Neuronal Calcium Activity

CaNetiCs——用于标准化降低神经元钙活动维度的开源工具箱

期刊:

影响因子:

doi:10.1101/2025.08.01.668030

Carbonero, Daniel; Noueihed, Jad; Gabel, Christopher V; Kramer, Mark A; White, John A

神经科学

发表日期：2025

文献求助收藏

Global excitatory synchrony: Ketamine induces global common-mode excitatory network oscillation by decoupling key interneurons.

全局兴奋性同步：氯胺酮通过解耦关键中间神经元诱导全局共模兴奋性网络振荡

期刊:

影响因子:

doi:10.1101/2025.08.02.667727

Karakullukcu Belen, White Hamilton, Connor Christopher, Gabel Christopher

神经科学

发表日期：2025

文献求助收藏

Pharmacological Analysis of NLRP3 Inflammasome Inhibitor Sodium [(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl][(1-methyl-1H-pyrazol-4-yl)({[(2S)-oxolan-2-yl]methyl})sulfamoyl]azanide in Cellular and Mouse Models of Inflammation Provides a Translational Framework.

在细胞和小鼠炎症模型中对 NLRP3 炎症小体抑制剂钠 [(1,2,3,5,6,7-六氢-s-茚满-4-基)氨基甲酰基][(1-甲基-1H-吡唑-4-基)({[(2S)-氧杂环戊烷-2-基]甲基})磺酰胺酰基]氮化物进行药理学分析，为转化应用提供了框架

期刊:ACS Pharmacology and Translational Science

影响因子:3.7

doi:10.1021/acsptsci.4c00061

Doedens John R, Smolak Pamela, Nguyen MyTrang, Wescott Heather, Diamond Christine, Schooley Ken, Billinton Andy, Harrison David, Koller Beverly H, Watt Alan P, Gabel Christopher A

CNS-targeted NLRP3 Inhibition by NT-0527 confers therapeutic advantage in a CAPS mouse model.

NT-0527 对 CNS 靶向 NLRP3 的抑制作用在 CAPS 小鼠模型中具有治疗优势。

Mice humanized by syntenic replacement with full-length NLRP3 disease-associated variants model the clinical cryopyrinopathy continuum

通过将全长NLRP3疾病相关变异体进行同源替换而人源化的小鼠模型模拟了临床冷吡啉病连续谱。

Ester Prodrug NLRP3 Inflammasome Inhibitor NT-0796 is Brain Active due to Activation by Local Expression of Carboxylesterase-1

酯类前药 NLRP3 炎症小体抑制剂 NT-0796 因羧酸酯酶-1 的局部表达而被激活，从而具有脑活性。

Neuronal Dynamics During Isoflurane Induction in Caenorhabditis elegans

异氟烷诱导秀丽隐杆线虫神经元动力学

Profile of NT-0527, a brain penetrant NLRP3 Inflammasome inhibitor suitable as an in vivo tool compound for neuroinflammatory disorders.

NT-0527 是一种可穿透血脑屏障的 NLRP3 炎症小体抑制剂，适用于作为神经炎症性疾病的体内治疗药物

Anesthesia isn't sleep: The neuronal dynamics of immobility in isoflurane-anesthetized C. elegans differ from the activity patterns of previously established sleep-like quiescent states

麻醉并非睡眠：异氟烷麻醉的秀丽隐杆线虫静止状态下的神经元动力学与先前建立的类似睡眠的静息状态的活动模式不同

IPSC-based modeling of resiliency in centenarians reveals longevity-specific signatures

基于IPSC的百岁老人韧性建模揭示了长寿特有的特征

CaNetiCs - An Open-Source Toolbox for Standardized Dimensionality Reduction of Neuronal Calcium Activity

CaNetiCs——用于标准化降低神经元钙活动维度的开源工具箱

Global excitatory synchrony: Ketamine induces global common-mode excitatory network oscillation by decoupling key interneurons.

全局兴奋性同步：氯胺酮通过解耦关键中间神经元诱导全局共模兴奋性网络振荡

Pharmacological Analysis of NLRP3 Inflammasome Inhibitor Sodium [(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl][(1-methyl-1H-pyrazol-4-yl)({[(2S)-oxolan-2-yl]methyl})sulfamoyl]azanide in Cellular and Mouse Models of Inflammation Provides a Translational Framework.

在细胞和小鼠炎症模型中对 NLRP3 炎症小体抑制剂钠 [(1,2,3,5,6,7-六氢-s-茚满-4-基)氨基甲酰基][(1-甲基-1H-吡唑-4-基)({[(2S)-氧杂环戊烷-2-基]甲基})磺酰胺酰基]氮化物进行药理学分析，为转化应用提供了框架