Gabel Christopher A相关文献与解析，生知库

Mice humanized by syntenic replacement with full-length NLRP3 disease-associated variants model the clinical cryopyrinopathy continuum

通过将全长NLRP3疾病相关变异体进行同源替换而人源化的小鼠模型模拟了临床冷吡啉病连续谱。

期刊:JCI Insight

影响因子:6.1

doi:10.1172/jci.insight.194677

Snouwaert, John N; Nguyen, MyTrang; Gabel, Christopher A; Aksentijevich, Ivona; Ting, Jenny P-Y; Koller, Beverly H

Ester Prodrug NLRP3 Inflammasome Inhibitor NT-0796 is Brain Active due to Activation by Local Expression of Carboxylesterase-1

酯类前药 NLRP3 炎症小体抑制剂 NT-0796 因羧酸酯酶-1 的局部表达而被激活，从而具有脑活性。

期刊:ACS Chemical Neuroscience

影响因子:3.9

doi:10.1021/acschemneuro.5c00843

Digby, Zsofia; Diamond, Christine; Wescott, Heather; Smolak, Pam; Thornton, Peter; Lindsay, Nicola; Gabel, Christopher A; Clarke, Nicholas; Watt, Alan P

Profile of NT-0527, a brain penetrant NLRP3 Inflammasome inhibitor suitable as an in vivo tool compound for neuroinflammatory disorders.

NT-0527 是一种可穿透血脑屏障的 NLRP3 炎症小体抑制剂，适用于作为神经炎症性疾病的体内治疗药物

期刊:RSC Medicinal Chemistry

影响因子:3.6

doi:10.1039/d5md00639b

Harrison David, Billinton Andy, Bock Mark G, Clarke Nicholas P, Digby Zsofia, Gabel Christopher A, Lindsay Nicola, Reader ValÃ©rie, Scanlon Jane, Smolak Pamela, Thornton Peter, Wescott Heather, Watt Alan P

Pharmacological Analysis of NLRP3 Inflammasome Inhibitor Sodium [(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl][(1-methyl-1H-pyrazol-4-yl)({[(2S)-oxolan-2-yl]methyl})sulfamoyl]azanide in Cellular and Mouse Models of Inflammation Provides a Translational Framework.

在细胞和小鼠炎症模型中对 NLRP3 炎症小体抑制剂钠 [(1,2,3,5,6,7-六氢-s-茚满-4-基)氨基甲酰基][(1-甲基-1H-吡唑-4-基)({[(2S)-氧杂环戊烷-2-基]甲基})磺酰胺酰基]氮化物进行药理学分析，为转化应用提供了框架

期刊:ACS Pharmacology and Translational Science

影响因子:3.7

doi:10.1021/acsptsci.4c00061

Doedens John R, Smolak Pamela, Nguyen MyTrang, Wescott Heather, Diamond Christine, Schooley Ken, Billinton Andy, Harrison David, Koller Beverly H, Watt Alan P, Gabel Christopher A

Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome

人类和患有DNMT3A过度生长综合征的小鼠的功能和表观遗传表型

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-021-24800-7

Amanda M Smith ，Taylor A LaValle ，Marwan Shinawi ，Sai M Ramakrishnan ，Haley J Abel ，Cheryl A Hill ，Nicole M Kirkland ，Michael P Rettig ，Nichole M Helton ，Sharon E Heath ，Francesca Ferraro ，David Y Chen ，Sangeeta Adak ，Clay F Semenkovich ，Diana L Christian ，Jenna R Martin ，Harrison W Gabel ，Christopher A Miller ，Timothy J Ley

P2 purinergic receptor modulation of cytokine production

P2嘌呤能受体对细胞因子产生的调节作用

期刊:Purinergic Signalling

影响因子:2.4

doi:10.1007/s11302-006-9034-y

CNS-targeted NLRP3 Inhibition by NT-0527 confers therapeutic advantage in a CAPS mouse model.

NT-0527 对 CNS 靶向 NLRP3 的抑制作用在 CAPS 小鼠模型中具有治疗优势。

Mice humanized by syntenic replacement with full-length NLRP3 disease-associated variants model the clinical cryopyrinopathy continuum

通过将全长NLRP3疾病相关变异体进行同源替换而人源化的小鼠模型模拟了临床冷吡啉病连续谱。

Ester Prodrug NLRP3 Inflammasome Inhibitor NT-0796 is Brain Active due to Activation by Local Expression of Carboxylesterase-1

酯类前药 NLRP3 炎症小体抑制剂 NT-0796 因羧酸酯酶-1 的局部表达而被激活，从而具有脑活性。

Profile of NT-0527, a brain penetrant NLRP3 Inflammasome inhibitor suitable as an in vivo tool compound for neuroinflammatory disorders.

NT-0527 是一种可穿透血脑屏障的 NLRP3 炎症小体抑制剂，适用于作为神经炎症性疾病的体内治疗药物

Pharmacological Analysis of NLRP3 Inflammasome Inhibitor Sodium [(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl][(1-methyl-1H-pyrazol-4-yl)({[(2S)-oxolan-2-yl]methyl})sulfamoyl]azanide in Cellular and Mouse Models of Inflammation Provides a Translational Framework.

在细胞和小鼠炎症模型中对 NLRP3 炎症小体抑制剂钠 [(1,2,3,5,6,7-六氢-s-茚满-4-基)氨基甲酰基][(1-甲基-1H-吡唑-4-基)({[(2S)-氧杂环戊烷-2-基]甲基})磺酰胺酰基]氮化物进行药理学分析，为转化应用提供了框架

Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome

人类和患有DNMT3A过度生长综合征的小鼠的功能和表观遗传表型

P2 purinergic receptor modulation of cytokine production

P2嘌呤能受体对细胞因子产生的调节作用